|
65677590212eaade2e0e1f48
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20150081910001
|
108191
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0445609
|
0
|
0
|
0
|
0.0445609
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
PROFILING EIF2A-DEPENDENT TRAN...SLATION IN SYNAPTIC PLASTICITY AND MEMORY
more
|
Profiling eIF2a-Dependent Tran...slation in Synaptic Plasticity and Memory
more
|
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Royal Institution for the ...Advancement of Learning/McGill University
more
|
|
|
|
65677590212eaade2e0e1f49
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20150081920001
|
108192
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0432393
|
0
|
0
|
0
|
0.0432393
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
CIRCUIT FORMATION BY SPATIO-TE...MPORAL CONTROL OF MESSENGER RNA TRANSLATION
more
|
Circuit Formation by Spatio-Te...mporal Control of Messenger RNA Translation
more
|
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Institut de recherches cliniqu...es de Montréal
more
|
|
|
|
65677590212eaade2e0e1f4a
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20160084050001
|
108405
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.004511
|
0
|
0
|
0
|
0.004511
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
THE TWO FACES OF ENDOGENOUS DN...A EDITING ENZYMES: PROMOTING GENE MUTATIONS AS WELL AS GENOME REPAIR
more
|
The two faces of endogenous DN...A editing enzymes: Promoting gene mutations as well as genome repair
more
|
Type B lymphocytes are a speci...fic type of white blood cell within our immune system. They produce and export antibodies which seek out, attach to, and neutralize microbes and toxins. A unique way that B lymphocytes boost their antibody response is through making changes in the genes that encode for antibodies. These genetic changes in B lymphocytes are carried out by AID, an enzyme that alters the sequence of antibody genes, leading to improved antibodies and hence improved immunity. However, AID activity is often misdirected to the wrong genes, or mis-expressed in the wrong cell types. This results in genetic mutations that can transform healthy cells into cancers. As a result, AID is now recognized as a leading cause of aggressive lymphoma/leukaemia and several solid tissue tumours. Furthermore, continued AID activity in cancer cells increases their ability to mutate and therefore become resistant to therapeutic approaches. Thus, the current scientific belief is that AID causes mutations to the genome of cells which in turn results in causing and/or exacerbating cancer. Strong preliminary data hints at the possibility of a completely new aspect of AID activity: DNA damaged by external sources such as radiation can itself attract AID and this may serve to correct/repair some of the damage. The aim of this project is to study the extent and mechanisms of this effect, and investigate whether it represents a possible pathway by which cancer cells can evade or become resistant to chemotherapy or radiation therapy, since many cancer therapies work through inducing DNA damage. The results of this project may have important implications for cancer treatment strategies.The project is led in Canada by Memorial University of Newfoundland in collaboration with the Hebrew University of Jerusalem (Israel) and researchers from Pakistan and India. It was selected and approved for funding through the second research competition of the Joint Canada-Israel Health Research Program, which is a partnership between Canada's International Development Research Centre, the Canadian Institutes for Health Research, the Israel Science Foundation and the Azrieli Foundation. This seven-year, $35M Canadian-Israeli effort draws on the unique scientific strengths of both countries and facilitates networking opportunities with peers from Africa, Asia, and Latin America. Projects include a plan for integrating researchers from low- and middle-income countries that will establish long-term scientific relationships.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Memorial University of Newfoun...dland
more
|
|
|
|
65677590212eaade2e0e1f4b
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086170001
|
108617
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0776433
|
0
|
0
|
0
|
0.0776433
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SUPPORTING THE COMMUNICATION A...ND DISSEMINATION OF RESEARCH ON WOMEN'S, CHILDREN, AND ADOLESCENT HEALTH
more
|
Supporting the communication a...nd dissemination of research on women's, children, and adolescent health
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
11000
|
Donor Government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/
more
|
|
|
|
65677590212eaade2e0e1f4c
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086170004
|
108617
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0192886
|
0
|
0
|
0
|
0.0192886
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SUPPORTING THE COMMUNICATION A...ND DISSEMINATION OF RESEARCH ON WOMEN'S, CHILDREN, AND ADOLESCENT HEALTH
more
|
Supporting the communication a...nd dissemination of research on women's, children, and adolescent health
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
21000
|
International NGO
|
Personal Connected Health Alli...ance
more
|
|
|
|
65677590212eaade2e0e1f4d
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086170006
|
108617
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0192115
|
0
|
0
|
0
|
0.0192115
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SUPPORTING THE COMMUNICATION A...ND DISSEMINATION OF RESEARCH ON WOMEN'S, CHILDREN, AND ADOLESCENT HEALTH
more
|
Supporting the communication a...nd dissemination of research on women's, children, and adolescent health
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Viva Salud asbl
|
|
|
|
65677591212eaade2e0e1f4e
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086170003
|
108617
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0192886
|
0
|
0
|
0
|
0.0192886
|
0
|
0
|
0.0192886
|
0
|
0
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SUPPORTING THE COMMUNICATION A...ND DISSEMINATION OF RESEARCH ON WOMEN'S, CHILDREN, AND ADOLESCENT HEALTH
more
|
Supporting the communication a...nd dissemination of research on women's, children, and adolescent health
more
|
The health of women, children,... and adolescents is a key Canadian government development priority. It is also part of the global Sustainable Development Goals (SDG). In alignment with these global priorities, the Maternal and Child Health program is supporting a rich portfolio of implementation research projects that work towards improving the quality, accessibility, and accountability of health services in low and middle-income countries (LMIC).Building on this strong foundation of research, IDRC is exploring new frontiers by supporting complementary research efforts around health information systems and adolescent sexual and reproductive health and rights, with a focus on populations in fragile contexts in West Africa, North Africa, and the Middle East. IDRC's approach has been to support LMIC researchers, policymakers and implementers in a participatory manner, to facilitate opportunities to influence national, regional, and global agendas through strategic convening and dialogues, and to use and disseminate research results.This project aims to communicate the strategic priorities of the program, and to disseminate research results of supported projects to produce greater visibility and reach for impact. A suite of engaging communication products will be developed through this fund to disseminate research results, and to enable the strategic involvement of IDRC grantees in key events to promote knowledge exchange and to influence policies, practices, agendas, and funding priorities. Funds will also support knowledge translation activities that arise, such as grantee engagement in high-level meetings and events, to take advantage of opportunities that enable the mobilization of knowledge into policy processes.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
21000
|
International NGO
|
Personal Connected Health Alli...ance
more
|
|
|
|
65677591212eaade2e0e1f4f
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086170005
|
108617
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0192115
|
0
|
0
|
0
|
0.0192115
|
0
|
0
|
0.0192115
|
0
|
0
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SUPPORTING THE COMMUNICATION A...ND DISSEMINATION OF RESEARCH ON WOMEN'S, CHILDREN, AND ADOLESCENT HEALTH
more
|
Supporting the communication a...nd dissemination of research on women's, children, and adolescent health
more
|
The health of women, children,... and adolescents is a key Canadian government development priority. It is also part of the global Sustainable Development Goals (SDG). In alignment with these global priorities, the Maternal and Child Health program is supporting a rich portfolio of implementation research projects that work towards improving the quality, accessibility, and accountability of health services in low and middle-income countries (LMIC).Building on this strong foundation of research, IDRC is exploring new frontiers by supporting complementary research efforts around health information systems and adolescent sexual and reproductive health and rights, with a focus on populations in fragile contexts in West Africa, North Africa, and the Middle East. IDRC's approach has been to support LMIC researchers, policymakers and implementers in a participatory manner, to facilitate opportunities to influence national, regional, and global agendas through strategic convening and dialogues, and to use and disseminate research results.This project aims to communicate the strategic priorities of the program, and to disseminate research results of supported projects to produce greater visibility and reach for impact. A suite of engaging communication products will be developed through this fund to disseminate research results, and to enable the strategic involvement of IDRC grantees in key events to promote knowledge exchange and to influence policies, practices, agendas, and funding priorities. Funds will also support knowledge translation activities that arise, such as grantee engagement in high-level meetings and events, to take advantage of opportunities that enable the mobilization of knowledge into policy processes.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Viva Salud asbl
|
|
|
|
65677591212eaade2e0e1f50
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20170086170002
|
108617
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0169197
|
0
|
0
|
0
|
0.0169197
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SUPPORTING THE COMMUNICATION A...ND DISSEMINATION OF RESEARCH ON WOMEN'S, CHILDREN, AND ADOLESCENT HEALTH??????
more
|
Supporting the communication a...nd dissemination of research on women's, children, and adolescent health??????
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
11000
|
Donor Government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/
more
|
|
|
|
65677591212eaade2e0e1f51
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170086400001
|
108640
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.009879
|
0
|
0
|
0
|
0.009879
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
REPRODUCTIVE, MATERNAL, NEWBOR...N, CHILD & ADOLESCENT HEALTH IN CONFLICT SETTINGS: CASE STUDIES TO INFORM IMPLEMENTATION OF INTERVENTIONS
more
|
Reproductive, maternal, newbor...n, child & adolescent health in conflict settings: case studies to inform implementation of interventions
more
|
This research project will con...tribute to evidence from four country case studies in Syria, South Sudan, Mali, and Colombia or the Democratic Republic of Congo as part of a global project to inform developing operational guidance on interventions related to reproductive, maternal, newborn, child, and adolescent health (RMNCAH) in conflict settings. The objectives of this project are to understand how decisions on RMNCAH interventions in conflict settings are reached, the gaps in service provision and in the populations reached, and the impact of such interventions, including intervention delivery strategies. The project will be conducted by a global academic research consortium led by the SickKids Hospital's Centre for Global Child Health (Canada) in collaboration with local academic and implementation partners. The outcomes include a set of five papers in an early 2019 issue of The Lancet that will synthesize findings from across this global project and will be launched at the International Congress of Pediatrics in March 2019. There will be other venues of dissemination, including conferences, symposia, and in-country dissemination of findings.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
5,3
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Hospital for Sick Children
|
|
|
|
65677591212eaade2e0e1f52
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088020002
|
108802
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.005637
|
0
|
0
|
0
|
0.005637
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
ASSESSMENT AND DEVELOPMENT OF ...IMPLEMENTATION MODELS OF HEALTH-RELATED SUSTAINABLE DEVELOPMENT GOALS
more
|
Assessment and development of ...implementation models of health-related Sustainable Development Goals
more
|
This research project, a colla...boration between IDRC and Aga Khan Foundation Canada, seeks ultimately to advance the global attainment of the health-related Sustainable Development Goals (SDGs). Similar to IDRC's Think Health exploratory efforts to understand the implementation of the health-related SDGs over the last two years, Aga Khan University has also been exploring how best to support SDG implementation at national levels. Shared findings from IDRC and Aga Khan University's respective work in this area show that implementation and monitoring approaches vary between countries and it is essential to understand patterns of interaction, bottlenecks and contextual factors. There is a great learning opportunity in sharing and building on these results from the exploratory initiatives. The project will review and conduct a global synthesis of literature, IDRC Think Health project outputs from 2016-2017, Aga Khan University consultation outputs from 2017, and existing strategies and concepts for implementing and monitoring health-related SDGs. This will result in a systematic review addressing health-related SDG implementation strategies. The project will be supplemented by evidence generated from targeted consultations in five countries that aim to bring together different stakeholders contributing to health outcomes. Finally, the project aims to deliver integrated implementation tools, evidence-based policy briefs, and scientific papers relevant to global and national policy makers regarding SDG implementation. The project aligns with the 2030 Global Agenda for Sustainable Development and is closely aligned with Canada's Policy for Civil Society Partnerships for International Assistance.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Aga Khan Foundation Canada/Fon...dation Aga Khan Canada
more
|
|
|
|
65677591212eaade2e0e1f53
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088020001
|
108802
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.004802
|
0
|
0
|
0
|
0.004802
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
ASSESSMENT AND DEVELOPMENT OF ...IMPLEMENTATION MODELS OF HEALTH-RELATED SUSTAINABLE DEVELOPMENT GOALS
more
|
Assessment and development of ...implementation models of health-related Sustainable Development Goals
more
|
This research project, a colla...boration between IDRC and Aga Khan Foundation Canada, seeks ultimately to advance the global attainment of the health-related Sustainable Development Goals (SDGs). Similar to IDRC's Think Health exploratory efforts to understand the implementation of the health-related SDGs over the last two years, Aga Khan University has also been exploring how best to support SDG implementation at national levels. Shared findings from IDRC and Aga Khan University's respective work in this area show that implementation and monitoring approaches vary between countries and it is essential to understand patterns of interaction, bottlenecks and contextual factors. There is a great learning opportunity in sharing and building on these results from the exploratory initiatives. The project will review and conduct a global synthesis of literature, IDRC Think Health project outputs from 2016-2017, Aga Khan University consultation outputs from 2017, and existing strategies and concepts for implementing and monitoring health-related SDGs. This will result in a systematic review addressing health-related SDG implementation strategies. The project will be supplemented by evidence generated from targeted consultations in five countries that aim to bring together different stakeholders contributing to health outcomes. Finally, the project aims to deliver integrated implementation tools, evidence-based policy briefs, and scientific papers relevant to global and national policy makers regarding SDG implementation. The project aligns with the 2030 Global Agenda for Sustainable Development and is closely aligned with Canada's Policy for Civil Society Partnerships for International Assistance.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Aga Khan Foundation Canada/Fon...dation Aga Khan Canada
more
|
|
|
|
65677591212eaade2e0e1f54
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180088050002
|
108805
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0487624
|
0
|
0
|
0
|
0.0487624
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
TRAVEL SPONSORSHIP TO THE SECO...ND PLANETARY HEALTH ANNUAL MEETING
more
|
Travel sponsorship to the seco...nd Planetary Health Annual Meeting
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The University Court of The Un...iversity of Edinburgh
more
|
|
|
|
65677591212eaade2e0e1f55
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180088050001
|
108805
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0487624
|
0
|
0
|
0
|
0.0487624
|
0
|
0
|
0.0487624
|
0
|
0
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
TRAVEL SPONSORSHIP TO THE SECO...ND PLANETARY HEALTH ANNUAL MEETING
more
|
Travel sponsorship to the seco...nd Planetary Health Annual Meeting
more
|
This research support project ...will provide travel scholarships for up to 30 young scientists (graduate students and/or post-docs) from low and middle-income countries to attend the second Planetary Health Annual Meeting in Edinburgh, Scotland, from May 29–June 1, 2018. The travel scholarships will facilitate the contribution of perspectives and experiences from young researchers from the Global South to stimulate interdisciplinary collaboration and build a rigorous evidence base for informing policy solutions that optimize both human health and environmental stewardship. The funding forms part of IDRC's formal co-sponsorship role to the Planetary Health Annual Meeting, organized by the Planetary Health Alliance and hosted by the University of Edinburgh, in collaboration with the American Geophysical Union, the Wellcome Trust, The Lancet Planetary Health initiative, and Future Earth. The aim of the meeting is to bring new scientific and development communities from around the world together to stimulate interdisciplinary collaboration to develop groundbreaking solutions to major planetary health challenges. Key objectives of the meeting are to examine how the health impacts of various global environmental changes are being manifested in different regional settings, and to highlight emerging responses to planetary health issues.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The University Court of The Un...iversity of Edinburgh
more
|
|
|
|
65677591212eaade2e0e1f56
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088730002
|
108873
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.07365
|
0
|
0
|
0
|
0.07365
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
FUNCTIONAL CONNECTOMICS OF PER...IPHERAL AND CENTRAL PAIN CIRCUITS
more
|
Functional connectomics of per...ipheral and central pain circuits
more
|
Chronic pain places a major bu...rden on society due to its debilitating effects on patients and on national economies due to lost productivity (estimated at CA$40 billion in Canada). Current therapeutic options for chronic pain sufferers are limited and new approaches to managing chronic pain are needed. This requires an in-depth understanding about the processing of nociceptive (perception of pain) information in both the peripheral and central nervous systems. Nerve injury can give rise to persistent changes in plasticity in both spinal cord and brain circuits that in turn lead to chronic pain. Although much progress has been made in understanding how nociceptive signals are transmitted and regulated, much less is known about how the brain is altered during chronic pain conditions, and how these changes in the pain axis contribute to the maintenance of chronic pain states. This project will use a functional connectomics approach, which maps connections within the nervous system, involving different mouse models of neuropathic pain. This will be coupled with optogenetic (light) manipulation of brain circuits and behavioural assessments. It aims to test the innovative hypothesis that changes in the plasticity of the pain axis following chronic nerve injury leads to a persistent loss of pain modulation. Successful completion of this project will provide unparalleled insights into the processing of pain signals in the brain and may identify novel therapeutic avenues for intervention. Additionally, the project will provide a strong research environment, as well as capacity building and exchange opportunities for graduate students, clinicians, and researchers based in Brazil. The project is led in Canada by the University of Calgary, in collaboration with the Hebrew University of Jerusalem in Israel, and Universidade Federal Do Parana in Brazil.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Governors of The Universit...y of Calgary
more
|
|
|
|
65677591212eaade2e0e1f57
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088730001
|
108873
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.062742
|
0
|
0
|
0
|
0.062742
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
FUNCTIONAL CONNECTOMICS OF PER...IPHERAL AND CENTRAL PAIN CIRCUITS
more
|
Functional connectomics of per...ipheral and central pain circuits
more
|
Chronic pain places a major bu...rden on society due to its debilitating effects on patients and on national economies due to lost productivity (estimated at CA$40 billion in Canada). Current therapeutic options for chronic pain sufferers are limited and new approaches to managing chronic pain are needed. This requires an in-depth understanding about the processing of nociceptive (perception of pain) information in both the peripheral and central nervous systems. Nerve injury can give rise to persistent changes in plasticity in both spinal cord and brain circuits that in turn lead to chronic pain. Although much progress has been made in understanding how nociceptive signals are transmitted and regulated, much less is known about how the brain is altered during chronic pain conditions, and how these changes in the pain axis contribute to the maintenance of chronic pain states. This project will use a functional connectomics approach, which maps connections within the nervous system, involving different mouse models of neuropathic pain. This will be coupled with optogenetic (light) manipulation of brain circuits and behavioural assessments. It aims to test the innovative hypothesis that changes in the plasticity of the pain axis following chronic nerve injury leads to a persistent loss of pain modulation. Successful completion of this project will provide unparalleled insights into the processing of pain signals in the brain and may identify novel therapeutic avenues for intervention. Additionally, the project will provide a strong research environment, as well as capacity building and exchange opportunities for graduate students, clinicians, and researchers based in Brazil. The project is led in Canada by the University of Calgary, in collaboration with the Hebrew University of Jerusalem in Israel, and Universidade Federal Do Parana in Brazil.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Governors of The Universit...y of Calgary
more
|
|
|
|
65677592212eaade2e0e1f58
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088740002
|
108874
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.066053
|
0
|
0
|
0
|
0.066053
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
MOLECULAR AND STRUCTURAL MECHA...NISMS OF ASTROCYTE-MEDIATED COGNITIVE ENHANCEMENT
more
|
Molecular and Structural Mecha...nisms of Astrocyte-Mediated Cognitive Enhancement
more
|
Long-lasting memories define w...ho we are and how we experience the world. Inability to form and access these memories, as in neurodegenerative conditions such as Alzheimer's disease (AD), degrades quality of life and imposes a major burden on healthcare systems and society. Unfortunately, medical treatments that can prevent, slow down, or reverse memory deficits are non-existent. To develop new strategies for targeting diseases associated with memory impairments, a better understanding of how the brain acquires and encodes memories is urgently needed, and novel mechanisms must be effectively harnessed for therapeutic value. Recent studies have revealed the unique abilities of astrocytes, star-shaped cells in the brain, to communicate with surrounding neurons, which plays an important role in enhancing memory formation. These findings represent a new perspective on how neural activity is regulated in the brain and they have significant implications for the development of cognitive augmentation treatments that can be applied in diseases such as AD. This project will apply cutting-edge techniques to investigate the effect of astrocytic activation on the physiological, molecular, and structural properties of astrocytes and their neighbouring neurons and circuits. It will use this knowledge to rescue or mitigate cellular pathology, functional disruptions, and cognitive deficits in AD mice models. Results will provide a major step forward in understanding the mechanisms by which astrocytes directly regulate memory formation and uncover new modes of therapeutic intervention for brain diseases such as AD. Additionally, the project will provide a strong research environment, as well as capacity building and exchange opportunities for graduate students, clinicians, and researchers based in Chile and China. The project is led in Canada by McGill University, working in collaboration with the Hebrew University of Jerusalem in Israel, Zhejiang University in China, and Universidad de Chile.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Research Institute of the ...McGill University Health Centre/L' Institut de recherche du centre uni
more
|
|
|
|
65677592212eaade2e0e1f59
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088740001
|
108874
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.056263
|
0
|
0
|
0
|
0.056263
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
MOLECULAR AND STRUCTURAL MECHA...NISMS OF ASTROCYTE-MEDIATED COGNITIVE ENHANCEMENT
more
|
Molecular and Structural Mecha...nisms of Astrocyte-Mediated Cognitive Enhancement
more
|
Long-lasting memories define w...ho we are and how we experience the world. Inability to form and access these memories, as in neurodegenerative conditions such as Alzheimer's disease (AD), degrades quality of life and imposes a major burden on healthcare systems and society. Unfortunately, medical treatments that can prevent, slow down, or reverse memory deficits are non-existent. To develop new strategies for targeting diseases associated with memory impairments, a better understanding of how the brain acquires and encodes memories is urgently needed, and novel mechanisms must be effectively harnessed for therapeutic value. Recent studies have revealed the unique abilities of astrocytes, star-shaped cells in the brain, to communicate with surrounding neurons, which plays an important role in enhancing memory formation. These findings represent a new perspective on how neural activity is regulated in the brain and they have significant implications for the development of cognitive augmentation treatments that can be applied in diseases such as AD. This project will apply cutting-edge techniques to investigate the effect of astrocytic activation on the physiological, molecular, and structural properties of astrocytes and their neighbouring neurons and circuits. It will use this knowledge to rescue or mitigate cellular pathology, functional disruptions, and cognitive deficits in AD mice models. Results will provide a major step forward in understanding the mechanisms by which astrocytes directly regulate memory formation and uncover new modes of therapeutic intervention for brain diseases such as AD. Additionally, the project will provide a strong research environment, as well as capacity building and exchange opportunities for graduate students, clinicians, and researchers based in Chile and China. The project is led in Canada by McGill University, working in collaboration with the Hebrew University of Jerusalem in Israel, Zhejiang University in China, and Universidad de Chile.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Research Institute of the ...McGill University Health Centre/L' Institut de recherche du centre uni
more
|
|
|
|
65677592212eaade2e0e1f5a
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088750002
|
108875
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.067619
|
0
|
0
|
0
|
0.067619
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
DECIPHERING THE BLUEPRINT OF T...HE HEALTHY AND DISEASED HUMAN BRAIN THROUGH THE GENERATION OF PATTERNED CEREBRAL ORGANOIDS
more
|
Deciphering the blueprint of t...he healthy and diseased human brain through the generation of patterned cerebral organoids
more
|
The cerebral cortex is the cen...tre of higher-order cognitive functioning in mammal brains. The cortex has undergone an evolutionary expansion and acquired a more sophisticated organization in humans. While the rodent cortex is small and smooth, human and primate cortices are large and convoluted. Nevertheless, key structural features have remained conserved throughout evolution. For instance, the neocortex is subdivided into four primary areas: visual, auditory, somatosensory, and motor. The allocortex is similarly regionalized, and includes the caudomedial hippocampus, which is the seat of learning and memory. How regional patterning occurs during development has been carefully studied in rodent models. Whether similar processes underlie patterning of the human cortex is unknown, but this is an important area of study given the association between neuropsychiatric disorders and altered connectivity between the thalamus and cortex. This project will use human stem cells to generate self-organizing cerebral organoids (a smaller, simpler version of the organ to be studied) and on-chip cerebral organoid systems to model early brain development and to investigate complex neuropsychiatric diseases, such as autism spectrum disorder. Additionally, the project will provide a strong research environment, as well as capacity building and exchange opportunities, for graduate students and researchers based in India. The project is led in Canada by the Sunnybrook Research Institute, working in collaboration with the Weizmann Institute of Science in Israel, and the Tata Institute of Fundamental Research in India.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
21000
|
International NGO
|
Sunnybrook Research Institute
|
|
|
|
65677592212eaade2e0e1f5b
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088750001
|
108875
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.057605
|
0
|
0
|
0
|
0.057605
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
DECIPHERING THE BLUEPRINT OF T...HE HEALTHY AND DISEASED HUMAN BRAIN THROUGH THE GENERATION OF PATTERNED CEREBRAL ORGANOIDS
more
|
Deciphering the blueprint of t...he healthy and diseased human brain through the generation of patterned cerebral organoids
more
|
The cerebral cortex is the cen...tre of higher-order cognitive functioning in mammal brains. The cortex has undergone an evolutionary expansion and acquired a more sophisticated organization in humans. While the rodent cortex is small and smooth, human and primate cortices are large and convoluted. Nevertheless, key structural features have remained conserved throughout evolution. For instance, the neocortex is subdivided into four primary areas: visual, auditory, somatosensory, and motor. The allocortex is similarly regionalized, and includes the caudomedial hippocampus, which is the seat of learning and memory. How regional patterning occurs during development has been carefully studied in rodent models. Whether similar processes underlie patterning of the human cortex is unknown, but this is an important area of study given the association between neuropsychiatric disorders and altered connectivity between the thalamus and cortex. This project will use human stem cells to generate self-organizing cerebral organoids (a smaller, simpler version of the organ to be studied) and on-chip cerebral organoid systems to model early brain development and to investigate complex neuropsychiatric diseases, such as autism spectrum disorder. Additionally, the project will provide a strong research environment, as well as capacity building and exchange opportunities, for graduate students and researchers based in India. The project is led in Canada by the Sunnybrook Research Institute, working in collaboration with the Weizmann Institute of Science in Israel, and the Tata Institute of Fundamental Research in India.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
21000
|
International NGO
|
Sunnybrook Research Institute
|
|
|
|
65677592212eaade2e0e1f5c
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088760002
|
108876
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.05982
|
0
|
0
|
0
|
0.05982
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
RESTORATION OF VISUAL FUNCTION... VIA PERCEPTUAL LEARNING THAT TARGETS SPECIFIC BRAIN AREAS
more
|
Restoration of visual function... via perceptual learning that targets specific brain areas
more
|
Following stroke or traumatic ...brain injury, many patients exhibit cortical visual impairment (CVI), usually in the form of a large blind spot in the visual field opposite the injury. In high-income countries, CVI is now the leading cause of vision loss in children, and pediatric CVI is ten times more prevalent in low-income countries. Overall, the population of CVI patients numbers approximately 20 million worldwide, the vast majority of whom receive no treatment whatsoever. CVI results specifically from damage to the primary visual cortex (area V1) or the structures leading to it, but most patients actually have access to visual input via a pathway from the eye to the extrastriate cortex, a collection of brain areas that encode complex visual stimuli. This pathway bypasses area V1, and it often supports a kind of subconscious vision known as blindsight. Although there is some evidence that this pathway can be strengthened with appropriate training protocols, there has been very little effort to design appropriate therapies. The aim of this project is to develop novel therapies for treating CVI, based on recent advances in our understanding of brain plasticity. More specifically, the research team will examine how the brain regions responsible for visual perception change when subjects are trained to identify particular visual stimuli. The project will also identify brain regions responsible for maintaining visual signals in memory across eye movements and develop training procedures that maximize the effectiveness of this integration. These findings will be used to design novel training protocols for CVI patients. The benefits will likely be greatest for pediatric patients, given their greater potential for plasticity. The project will provide a strong research environment and capacity building and exchange opportunities for graduate students, clinicians, and researchers based in Nepal. The project is led in Canada by McGill University in collaboration with the Hebrew University of Jerusalem in Israel and the Tilganga Institute of Ophthalmology in Nepal.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Royal Institution for the ...Advancement of Learning/McGill University
more
|
|
|
|
65677592212eaade2e0e1f5d
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088760001
|
108876
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.050962
|
0
|
0
|
0
|
0.050962
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
RESTORATION OF VISUAL FUNCTION... VIA PERCEPTUAL LEARNING THAT TARGETS SPECIFIC BRAIN AREAS
more
|
Restoration of visual function... via perceptual learning that targets specific brain areas
more
|
Following stroke or traumatic ...brain injury, many patients exhibit cortical visual impairment (CVI), usually in the form of a large blind spot in the visual field opposite the injury. In high-income countries, CVI is now the leading cause of vision loss in children, and pediatric CVI is ten times more prevalent in low-income countries. Overall, the population of CVI patients numbers approximately 20 million worldwide, the vast majority of whom receive no treatment whatsoever. CVI results specifically from damage to the primary visual cortex (area V1) or the structures leading to it, but most patients actually have access to visual input via a pathway from the eye to the extrastriate cortex, a collection of brain areas that encode complex visual stimuli. This pathway bypasses area V1, and it often supports a kind of subconscious vision known as blindsight. Although there is some evidence that this pathway can be strengthened with appropriate training protocols, there has been very little effort to design appropriate therapies. The aim of this project is to develop novel therapies for treating CVI, based on recent advances in our understanding of brain plasticity. More specifically, the research team will examine how the brain regions responsible for visual perception change when subjects are trained to identify particular visual stimuli. The project will also identify brain regions responsible for maintaining visual signals in memory across eye movements and develop training procedures that maximize the effectiveness of this integration. These findings will be used to design novel training protocols for CVI patients. The benefits will likely be greatest for pediatric patients, given their greater potential for plasticity. The project will provide a strong research environment and capacity building and exchange opportunities for graduate students, clinicians, and researchers based in Nepal. The project is led in Canada by McGill University in collaboration with the Hebrew University of Jerusalem in Israel and the Tilganga Institute of Ophthalmology in Nepal.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Royal Institution for the ...Advancement of Learning/McGill University
more
|
|
|
|
65677592212eaade2e0e1f5e
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088770002
|
108877
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.06688
|
0
|
0
|
0
|
0.06688
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SELECTIVE REAL-TIME MONITORING... OF DIVERSE NEURONAL TYPES IN THE BRAIN
more
|
Selective real-time monitoring... of diverse neuronal types in the brain
more
|
Cognitive processes emerge fro...m the collective activity of billions of neurons in the brain. The brain is composed of different types of neurons, defined by morphology, connectivity, and genetic expression. In particular, neurons of the mammalian cortex can be sub-divided into two broad classes: excitatory and inhibitory neurons. Alteration in the function of inhibitory cell networks can lead to debilitating neurological disorders that is observed, for example, in epilepsy. Thus, monitoring the electrical potentials (spikes) emitted by specific neuronal populations, possibly in real time, will open avenues in the understanding of neuronal networks in vivo and the development of new therapeutic approaches. This project aims to detect, sort, and classify in real time the spiking activity of different types of neurons in the brain. Findings of this project will provide foundations for the understanding of neuronal dynamics in vivo and the development of closed-loop scientific and therapeutic strategies. Additionally, the project will provide a strong research environment, as well as capacity building and exchange opportunities for graduate students and researchers based in Argentina and Mexico. The project is led in Canada by McGill University in collaboration with Tel Aviv University in Israel, Universidad Nacional Autonoma de Mexico, and Universidad de Buenos Aires in Argentina. This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Royal Institution for the ...Advancement of Learning/McGill University
more
|
|
|
|
65677592212eaade2e0e1f5f
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088770001
|
108877
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.056971
|
0
|
0
|
0
|
0.056971
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SELECTIVE REAL-TIME MONITORING... OF DIVERSE NEURONAL TYPES IN THE BRAIN
more
|
Selective real-time monitoring... of diverse neuronal types in the brain
more
|
Cognitive processes emerge fro...m the collective activity of billions of neurons in the brain. The brain is composed of different types of neurons, defined by morphology, connectivity, and genetic expression. In particular, neurons of the mammalian cortex can be sub-divided into two broad classes: excitatory and inhibitory neurons. Alteration in the function of inhibitory cell networks can lead to debilitating neurological disorders that is observed, for example, in epilepsy. Thus, monitoring the electrical potentials (spikes) emitted by specific neuronal populations, possibly in real time, will open avenues in the understanding of neuronal networks in vivo and the development of new therapeutic approaches. This project aims to detect, sort, and classify in real time the spiking activity of different types of neurons in the brain. Findings of this project will provide foundations for the understanding of neuronal dynamics in vivo and the development of closed-loop scientific and therapeutic strategies. Additionally, the project will provide a strong research environment, as well as capacity building and exchange opportunities for graduate students and researchers based in Argentina and Mexico. The project is led in Canada by McGill University in collaboration with Tel Aviv University in Israel, Universidad Nacional Autonoma de Mexico, and Universidad de Buenos Aires in Argentina. This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Royal Institution for the ...Advancement of Learning/McGill University
more
|
|
|
|
65677592212eaade2e0e1f60
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088780002
|
108878
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.066321
|
0
|
0
|
0
|
0.066321
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SYNAPTIC MECHANISMS UNDERLYING... PERCEPTUAL LEARNING
more
|
Synaptic Mechanisms underlying... Perceptual Learning
more
|
Plasticity is a hallmark of th...e brain, allowing animals to adapt to environmental and behavioural demands throughout life. Understanding the synaptic, cellular, and circuit basis of plasticity is at the heart of neuroscience research, yet its understanding in different forms of learning remains rudimentary. Perceptual Learning (PL) is an implicit form of lifelong learning where the animal improves its perceptual performance with practice. Despite extensive psychophysical research on PL, we have almost no understanding of its cellular and synaptic underpinnings. While the role of synaptic plasticity in learning and memory has been described for some types of learning such as fear-conditioning, is it not clear to what extent similar mechanisms can explain physiological forms of learning such as PL. The goal of this project is to identify the inhibitory and excitatory synaptic plasticity mechanisms occurring during sensory experience to produce PL. The team's preliminary data using in vivo electrophysiology and calcium imaging, provides a basis for a general hypothesis to explain frequency shifts of receptive fields toward trained frequencies. The project will provide a strong research environment as well as capacity building and exchange opportunities for graduate students and researchers based in Argentina. The project is led in Canada by the University of Toronto in collaboration with the Hebrew University of Jerusalem in Israel and the Instituto de Investigación en Biomedicina in Argentina.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Governing Council of the U...niversity of Toronto
more
|
|
|
|
65677592212eaade2e0e1f61
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20180088780001
|
108878
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.056494
|
0
|
0
|
0
|
0.056494
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SYNAPTIC MECHANISMS UNDERLYING... PERCEPTUAL LEARNING
more
|
Synaptic Mechanisms underlying... Perceptual Learning
more
|
Plasticity is a hallmark of th...e brain, allowing animals to adapt to environmental and behavioural demands throughout life. Understanding the synaptic, cellular, and circuit basis of plasticity is at the heart of neuroscience research, yet its understanding in different forms of learning remains rudimentary. Perceptual Learning (PL) is an implicit form of lifelong learning where the animal improves its perceptual performance with practice. Despite extensive psychophysical research on PL, we have almost no understanding of its cellular and synaptic underpinnings. While the role of synaptic plasticity in learning and memory has been described for some types of learning such as fear-conditioning, is it not clear to what extent similar mechanisms can explain physiological forms of learning such as PL. The goal of this project is to identify the inhibitory and excitatory synaptic plasticity mechanisms occurring during sensory experience to produce PL. The team's preliminary data using in vivo electrophysiology and calcium imaging, provides a basis for a general hypothesis to explain frequency shifts of receptive fields toward trained frequencies. The project will provide a strong research environment as well as capacity building and exchange opportunities for graduate students and researchers based in Argentina. The project is led in Canada by the University of Toronto in collaboration with the Hebrew University of Jerusalem in Israel and the Instituto de Investigación en Biomedicina in Argentina.This project was selected for funding through the fourth research competition of the Joint Canada-Israel Health Research Program. This initiative is a partnership between IDRC, the Canadian Institutes of Health Research, the Israel Science Foundation, and the Azrieli Foundation.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Governing Council of the U...niversity of Toronto
more
|
|
|
|
65677592212eaade2e0e1f62
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180089880002
|
108988
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D01
|
0
|
0.0150066
|
0
|
0
|
0
|
0.0150066
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
EVALUATION OF THE JOINT CANADA...-ISRAEL HEALTH RESEARCH PROGRAM
more
|
Evaluation of the Joint Canada...-Israel Health Research Program
more
|
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
11000
|
Donor Government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/
more
|
|
|
|
65677593212eaade2e0e1f63
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180089880001
|
108988
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D01
|
0.055937
|
0
|
0
|
0
|
0.055937
|
0
|
0
|
0.055937
|
0
|
0
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
EVALUATION OF THE JOINT CANADA...-ISRAEL HEALTH RESEARCH PROGRAM
more
|
Evaluation of the Joint Canada...-Israel Health Research Program
more
|
This project supports an evalu...ation of the Joint Canada-Israel Health Research Program, (JCIHRP) led by the Technopolis Group, a UK-based international consultancy focused on evaluating science, technology, and innovation. It is in support of the JCIHRP Memorandum of Understanding signed by the funding agencies, which calls for an external evaluation.The JCIHRP is a seven-year (2015-2022), CA$35 million partnership between IDRC, the Azrieli Foundation, the Canadian Institutes of Health Research, and the Israel Science Foundation. The program was designed to advance research and discovery in the biomedical sciences while encouraging collaboration between leading scientists in Canada, Israel, and low and middle-income countries. It also aims to provide capacity building opportunities for emerging leaders and trainees to gain expertise and experience in the broad field of biomedicine. The program will fund up to 30 research projects from 2015 to 2022. It is currently supporting 24 research teams through four competitions: Neurosciences (2015), Immunology (2016), Cancer (2017), and Neurobiology (2018). Metabolism in health and disease is the topic for the 2019 competition.
more
|
|
12182
|
Medical research
|
|
I.2.a. Health, General
|
11000
|
Donor Government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/
more
|
|
|
|
65677593212eaade2e0e1f64
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20110068640003
|
106864
|
3
|
Far East Asia, regional
|
Far East Asia
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0006592362
|
0
|
0
|
0
|
0.00387786
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
17
|
EXAMINING BURMA'S DEVELOPMENT:... A RESEARCH FELLOWSHIP PROGRAM
more
|
Examining Burma's Development:... A Research Fellowship Program
more
|
|
|
43081
|
Multisector education/training
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Chiang Mai University
|
|
|
|
65677593212eaade2e0e1f65
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180088000002
|
108800
|
3
|
Ghana
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0349025
|
0
|
0
|
0
|
0.0349025
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
POLICY RESEARCH INSTITUTIONS A...ND THE HEALTH SDGS: BUILDING MOMENTUM IN WEST AFRICA
more
|
Policy Research Institutions a...nd the Health SDGs: Building Momentum in West Africa
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
Initiative Prospective Agricol...e et Rurale
more
|
|
|
|
65677593212eaade2e0e1f66
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180088000001
|
108800
|
3
|
Ghana
|
South of Sahara
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0375295
|
0
|
0
|
0
|
0.0375295
|
0
|
0
|
0.0375295
|
0
|
0
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
POLICY RESEARCH INSTITUTIONS A...ND THE HEALTH SDGS: BUILDING MOMENTUM IN WEST AFRICA
more
|
Policy Research Institutions a...nd the Health SDGs: Building Momentum in West Africa
more
|
The 2017 Dakar consultation on... the health-related Sustainable Development Goals (SDGs) concluded with a wide consensus among the participants on the need for a regional coalition to accelerate progress towards the SDGs and track where and how the progress is happening. As a next step, this project aims to advance this consensus and identify key regional priorities for the health-related SDGs. Thereafter, propose mechanisms that can track progress towards the health-related SDGs nationally and regionally. The project will be led by Initiative Prospective Agricole et Rurale (IPAR), Senegal and the West African Health Organization (WAHO). Policy research institutions in Burkina Faso, Ghana, and Senegal will also collaborate in the research activities. In addition, the project aims to work with key civil society organizations across a range of social and economic sectors to analyze their involvement in implementing and monitoring of the health-related SDGs, including actions to ensure meaningful engagement and participation of women and marginalized groups. A key outcome of this project will be a deeper understanding of the key indicators and the extent to which the required data exists to monitor them. The results will be used to develop a multi-stakeholder SDG monitoring approach for the health related indicators in West Africa. The project aligns with the 2030 global agenda for sustainable development and is closely aligned with Canada's policy for civil society partnerships for international assistance.???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
more
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
Initiative Prospective Agricol...e et Rurale
more
|
|
|
|
65677593212eaade2e0e1f67
|
2020
|
Canada
|
International Development Rese...arch Centre
more
|
20170084530001
|
108453
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.133425
|
0
|
0
|
0
|
0.133425
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
CLIMATE ADAPTIVE ACTION PLANS ...TO MANAGE HEAT STRESS IN INDIAN CITIES
more
|
Climate adaptive action plans ...to manage heat stress in Indian cities
more
|
The Intergovernmental Panel on... Climate Change estimates that rising global temperatures will increase the amount and severity of heat waves. In India, these heat waves are exacerbated by the heat generated by human activities in urban areas. This has a considerable impact on the health of vulnerable communities, including a rise in fatalities. According to the Indian Meteorological Department, in 2015 alone more than 2,400 people died of heat-related causes. Despite projections by climate models of a warming climate and increasing frequency of extreme heat events in the coming years, in India the public recognition of the magnitude of these hazards remains low. Administrative support systems generally lack preparedness measures and data to quantify how heat stress affects human health, work productivity, and livelihoods. This project, implemented by the New Delhi-based organization Integrated Research for Action and Development, will support the development of location-specific and gender-sensitive heat stress action plans in Delhi, Bhubaneswar, and Rajkot. These plans will be based on quantitative and qualitative measures, primary and secondary data, and shared learning dialogues with stakeholders. The researchers, in collaboration with the municipal corporations, will identify the spatial vulnerability of populations during extreme heat events, analyze the impact of extreme heat events on health, work productivity, and livelihoods, select appropriate, innovative, and affordable climate adaptation measures that consider associated cost effectiveness and gender-based implications, provide training to urban planners, municipal commissioners, city engineers, officials from various healthcare centres, and municipal health officers to improve their ability to execute heat stress action plans, and organize policy workshops to facilitate the implementation of the heat stress action plans into municipal disaster strategies in the selected areas. The research process and plans developed are expected to influence appropriate adaptation actions and associated policy at the municipal scale, which will improve resilience and reduce vulnerability of more than 10 million at-risk people in the selected areas. The plans will be made available to the Natural Resources Defense Council and the Indian Institute of Public Health to enable an analysis of their potential to be applied to other cities in India.
more
|
|
41010
|
Environmental policy and admin...istrative management
more
|
13,11
|
IV.1. General Environment Prot...ection
more
|
23000
|
Developing country-based NGO
|
Integrated Research and Action... for Development
more
|
|
|
|
65677593212eaade2e0e1f68
|
2018
|
Canada
|
Miscellaneous
|
2018899917
|
161850-1
|
3
|
India
|
South & Central Asia
|
LMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0147597
|
0
|
0
|
0
|
0.0147597
|
0
|
0
|
0.0147597
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
DEVELOPING A COMMUNITY-BASED S...TUDY OF TRANSGENDER MEN'S HEALTH AND HUMAN RIGHTS IN INDIA
more
|
Developing a community-based s...tudy of transgender men's health and human rights in India
more
|
Transgender (trans) men or tra...nsmasculine persons are those who were assigned a female sex at birth but who identify as male or masculine. In a context of pervasive social stigma and discrimination, trans men experience a high burden of poor mental health and barriers to health care. However, the extant evidence is concentrated in developed countries and published research on trans men is low and middle-income countries is almost entirely lacking. India has a well-established trans community that has won advances in health and human rights, including a 2014 Supreme Court ruling that established rights to self-identification and to government social and health benefits. Trans men, however, have been largely overlooked in health and social policymaking in India. A lack of empirical data on the health and human rights situation of trans men in India is among the primary obstacles to the development of policies and practices that reflect their needs. To address this gap, we plan to bring together an interdisciplinary Indian-Canadian team to advance health equity for trans men by conducting the first quantitative study of trans men's health in India, using a community-based research approach. We propose planning activities including a scoping review, community consultations, and a planning retreat. The community consultations will engage trans men, community-based organizations, and healthcare providers to identify data needs, inform the study design, and develop partnerships. The retreat will focus on team-building and development of a CIHR Project Grant application, and the majority of attendees will be community members. As one of the first academic-community collaborations focused specifically on trans men's health in a LMIC, this project may serve as a model for future work and will provide much-needed evidence of trans men's health needs in LMIC.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
11000
|
Donor Government
|
St. Michael's Hospital (Toront...o)
more
|
|
|
|
65677593212eaade2e0e1f69
|
2018
|
Canada
|
Miscellaneous
|
2018899953a
|
158861-1
|
3
|
Iran
|
Middle East
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0
|
0.0101265
|
0
|
0
|
0
|
0.0101265
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
INTERRAI PILOT STUDY IN IRAN: ...INVESTIGATING THE NEEDS AND THE HEALTH STATUS OF IRANIAN ACUTE CARE OLDER PATIENTS
more
|
InterRai Pilot Study in Iran: ...Investigating the Needs and the Health Status of Iranian Acute Care Older Patients
more
|
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University of Waterloo (Ontari...o)
more
|
|
|
|
65677593212eaade2e0e1f6a
|
2018
|
Canada
|
Miscellaneous
|
2018899953b
|
158861-1
|
3
|
Iran
|
Middle East
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0.013502
|
0
|
0
|
0
|
0.013502
|
0
|
0
|
0.013502
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
INTERRAI PILOT STUDY IN IRAN: ...INVESTIGATING THE NEEDS AND THE HEALTH STATUS OF IRANIAN ACUTE CARE OLDER PATIENTS
more
|
InterRai Pilot Study in Iran: ...Investigating the Needs and the Health Status of Iranian Acute Care Older Patients
more
|
The population of older adults... is increasing globally. This demographic shift has created a mismatch between current acute care models that are focused on single-disease, episodic interventions and older adults' co-morbidities. Similar issues exist in Iranian acute care as lack of guidelines has led to high rates of misdiagnosis of older adults' conditions and over-crowding of intensive care units. Meanwhile it is speculated that interRAI, which is an international network dedicated to enhancing geriatric medicine through development of standardized surveys, could reconcile this mismatch in Iranian acute care. However, there is a paucity of research on Iranian older populations' acute care needs; therefore, it is difficult to identify which interRai tool will be most effective. To fill this gap, I am aiming to examine the current state of the geriatric acute care in Iran through a mixed-methods approach. First, I will investigate the health status of older adults at an emergency unit in Tehran as part of an interRAI's multi-national observational study.During the second phase of this project, I will interview 30-45 professional stakeholders, including policy-makers, epidemiologists, and clinicians. Throughout these interviews, I will inquire about the existing issues in Iranian geriatric acute care, older adults' needs from acute care, and interRAI's potential to solve some of these issues. This project is an opportunity to initiate collaboration between the interRAI group and the Iranian Ministry of Health. Such alliance could optimize Iranian geriatric care, enhance University of Waterloo's international relations, and strengthen interRAI's legacy
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University of Waterloo (Ontari...o)
more
|
|
|
|
65677593212eaade2e0e1f6b
|
2018
|
Canada
|
Miscellaneous
|
2018899943
|
159404-1
|
3
|
Iran
|
Middle East
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
D02
|
0.00381529
|
0.00381529
|
0
|
0
|
0.00381529
|
0.00381529
|
0
|
0.00381529
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
INTERRAI PILOT STUDY IN IRAN: ...INVESTIGATING THE NEEDS OF IRANIAN ACUTE CARE OLDER PATIENTS
more
|
InterRAI Pilot Study in Iran: ...Investigating the Needs of Iranian Acute Care Older Patients
more
|
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
University of Waterloo (Ontari...o)
more
|
|
|
|
65677593212eaade2e0e1f6c
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20110068640001
|
106864
|
3
|
Myanmar
|
South & Central Asia
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.00461465
|
0
|
0
|
0
|
0.027145
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
17
|
EXAMINING BURMA'S DEVELOPMENT:... A RESEARCH FELLOWSHIP PROGRAM
more
|
Examining Burma's Development:... A Research Fellowship Program
more
|
|
|
43081
|
Multisector education/training
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Chiang Mai University
|
|
|
|
65677594212eaade2e0e1f6d
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180088000004
|
108800
|
3
|
Senegal
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0359601
|
0
|
0
|
0
|
0.0359601
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
POLICY RESEARCH INSTITUTIONS A...ND THE HEALTH SDGS: BUILDING MOMENTUM IN WEST AFRICA
more
|
Policy Research Institutions a...nd the Health SDGs: Building Momentum in West Africa
more
|
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
Initiative Prospective Agricol...e et Rurale
more
|
|
|
|
65677594212eaade2e0e1f6e
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180088000003
|
108800
|
3
|
Senegal
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0386668
|
0
|
0
|
0
|
0.0386668
|
0
|
0
|
0.0386668
|
0
|
0
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
POLICY RESEARCH INSTITUTIONS A...ND THE HEALTH SDGS: BUILDING MOMENTUM IN WEST AFRICA
more
|
Policy Research Institutions a...nd the Health SDGs: Building Momentum in West Africa
more
|
The 2017 Dakar consultation on... the health-related Sustainable Development Goals (SDGs) concluded with a wide consensus among the participants on the need for a regional coalition to accelerate progress towards the SDGs and track where and how the progress is happening. As a next step, this project aims to advance this consensus and identify key regional priorities for the health-related SDGs. Thereafter, propose mechanisms that can track progress towards the health-related SDGs nationally and regionally. The project will be led by Initiative Prospective Agricole et Rurale (IPAR), Senegal and the West African Health Organization (WAHO). Policy research institutions in Burkina Faso, Ghana, and Senegal will also collaborate in the research activities. In addition, the project aims to work with key civil society organizations across a range of social and economic sectors to analyze their involvement in implementing and monitoring of the health-related SDGs, including actions to ensure meaningful engagement and participation of women and marginalized groups. A key outcome of this project will be a deeper understanding of the key indicators and the extent to which the required data exists to monitor them. The results will be used to develop a multi-stakeholder SDG monitoring approach for the health related indicators in West Africa. The project aligns with the 2030 global agenda for sustainable development and is closely aligned with Canada's policy for civil society partnerships for international assistance.???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
more
|
|
12110
|
Health policy and administrati...ve management
more
|
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
Initiative Prospective Agricol...e et Rurale
more
|
|
|
|
65677594212eaade2e0e1f6f
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180099060002
|
dev18LC
|
3
|
South America, regional
|
South America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D01
|
0
|
0.730702656
|
0
|
0
|
0
|
7.42584
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
9.84
|
IDRC - DEVELOPMENT RESEARCH - ...LATIN AMERICA AND CARIBBEAN
more
|
IDRC - Development Research - ...Latin America and Caribbean
more
|
|
Sparate calculation based on a...nnual reports assuming that the 4 components of "inclusive economies" account for 25% each
more
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
11000
|
Donor Government
|
International Development Rese...arch Centre
more
|
|
|
|
65677594212eaade2e0e1f70
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20180099060001
|
dev18LC
|
3
|
South America, regional
|
South America
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
D01
|
0.730702656
|
0
|
0
|
0
|
7.42584
|
0
|
0
|
0
|
0
|
7.42584
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
9.84
|
IDRC - DEVELOPMENT RESEARCH - ...LATIN AMERICA AND CARIBBEAN
more
|
IDRC - Development Research - ...Latin America and Caribbean
more
|
Development research costs of ...IDRC - Latin America and Caribbean
more
|
Sparate calculation based on a...nnual reports assuming that the 4 components of "inclusive economies" account for 25% each
more
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
11000
|
Donor Government
|
International Development Rese...arch Centre
more
|
|
|
|
65677594212eaade2e0e1f71
|
2018
|
Canada
|
International Development Rese...arch Centre
more
|
20110068640002
|
106864
|
3
|
Thailand
|
Far East Asia
|
UMICs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0013184741
|
0
|
0
|
0
|
0.00775573
|
0
|
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
17
|
EXAMINING BURMA'S DEVELOPMENT:... A RESEARCH FELLOWSHIP PROGRAM
more
|
Examining Burma's Development:... A Research Fellowship Program
more
|
|
|
43081
|
Multisector education/training
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Chiang Mai University
|
|
|
|
65677594212eaade2e0e1f72
|
2018
|
Canada
|
Miscellaneous
|
2018899985
|
161868-1
|
3
|
Zambia
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0.0127305
|
0
|
0
|
0
|
0.0127305
|
0
|
0
|
0.0127305
|
0
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
IDENTIFYING BARRIERS TO THE US...E OF SUB-NATIONAL HEALTH SYSTEMS DATA IN ZAMBIA
more
|
Identifying barriers to the us...e of sub-national health systems data in Zambia
more
|
Population and health system d...ata gaps have been identified as major global health challenges. Health Ministers from G7 countries, including Canada, have recently prioritized investing in data systems as part of global health system strengthening efforts. These data challenges are particularly dire in low and middle-income countries (LMICs), where there are fewer population and health systems data available. However, thanks to the spread of more powerful and more affordable information technologies and the investments of governments and donor partners, many LMICs are now implementing strong national health information systems (HIS). But while the scale-up of these systems has been relatively quick, the use of these data for both planning and research purposes has been markedly slower due both to poorly developed user interfaces to extract data as well as limited investments in capacity to extract and interpret data, in particular at the sub-national level. In short, simply collecting more data does not mean that such data will actually be used effectively and there is a need to understand barriers to the use of data at the sub-national level and expand capacity to facilitate the use of these data at the local level for health system planning and evaluation purposes. The purpose of this research project is to build upon this identified research priority and the expertise of our research team to build an innovative research program around the use of sub-national health system data in Zambia. The project will finance preliminary research, host a series of interviews and meeting meetings with knowledge users and other stakeholders, establish an innovative research agenda on the ways to improve data use at subnational levels to improve population level health, and further strengthen Canada's global health research expertise.
more
|
|
43082
|
Research/scientific institutio...ns
more
|
|
IV.2. Other Multisector
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Wilfrid Laurier University (Wa...terloo, Ontario)
more
|
|
|
|
65677595212eaade2e0e1f73
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
20180088003
|
108800
|
3
|
Burkina Faso
|
South of Sahara
|
LDCs
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0
|
0.00427928
|
0
|
0
|
0
|
0.00427928
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
POLICY RESEARCH INSTITUTIONS A...ND THE HEALTH SDGS: BUILDING MOMENTUM IN WEST AFRICA
more
|
Policy research institutions a...nd the health SDGs: Building momentum in West Africa
more
|
The 2017 Dakar consultation on... the health-related Sustainable Development Goals (SDGs) concluded with a wide consensus among participants on the need for a regional coalition to accelerate progress towards the SDGs and track where and how the progress is happening. As a next step, this project aims to advance this consensus and identify key regional priorities for the health-related SDGs. It will also propose mechanisms that can track progress towards the health-related SDGs nationally and regionally. The project will be led by Initiative Prospective Agricole et Rurale Sénégal and the West African Health Organization. Policy research institutions in Burkina Faso, Ghana, and Senegal will also collaborate in the research activities. In addition, the project aims to work with key civil society organizations across a range of social and economic sectors to analyze their involvement in implementing and monitoring the health-related SDGs, including actions to ensure meaningful engagement and participation of women and marginalized groups. A key outcome of this project will be a deeper understanding of the key indicators and the extent to which the required data exists to monitor them. The results will be used to develop a multi-stakeholder SDG monitoring approach for the health-related indicators in West Africa. The project aligns with the 2030 global agenda for sustainable development and is closely aligned with Canada's policy for civil society partnerships for international assistance.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
23000
|
Developing country-based NGO
|
Initiative Prospective Agricol...e et Rurale
more
|
|
|
|
65677596212eaade2e0e1f74
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
2015008189
|
108189
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0
|
0.0265741
|
0
|
0
|
0
|
0.0265741
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
THE EFFECT OF ANTIBIOTICS IN E...ARLY LIFE ON BRAIN FUNCTION AND BEHAVIOUR
more
|
The Effect of Antibiotics in E...arly Life on Brain Function and Behaviour
more
|
The human gastrointestinal tra...ct is home to 100 trillion microorganisms. Research has found that these microorganisms, known as gut microbiota, play an important role in the development and normal function of our immune and nervous systems. This project will offer important insights into how antibiotics might disrupt gut microbiota and affect brain function in young children.Brain chemistry and antibioticsRecent evidence in animal models suggests that gut microbiota can influence brain chemistry, which can affect behaviour. However, we do not know how this occurs. We also do not know how the disruption of normal gut microbiota early in life from antibiotic use, for example, might influence brain development and potentially contribute to behavioural and/or mood disorders. This project will seek to offer some answers. The research team will aim to:-understand the mechanisms underpinning the microbiome-gut-brain axis and the potential contribution of gut microbiota disruption to neurodevelopmental and behavioural disorders-determine the long-term impact of early life disruption of the gut microbiota on brain chemistry and behaviour related to anxiety and social interaction-delineate immune mechanisms linking the altered microbiota to behavioural changes-identify potentially novel components of the microbiota-gut-brain axis related to antibiotic effects on brain function and behaviour-further develop the training environment and collaborative research among the partnersUnderstanding the gut-brain linkThe successful completion of this project will provide a greater understanding of the mechanisms underpinning the connection between gut bacteria and the brain. It will provide insight into the gut microbiota disruption's potential contribution to the development of mood and behavioural disorders. This knowledge may help researchers develop novel approaches to maintaining mental health.Project leadershipThe project lead is Paul Forsythe at McMaster University, Hamilton, Canada. His collaborators include Omry Koren, Bar-Ilan University, Israel, and Javier Bravo and Marcela Julio, Pontificia Universidad Cato¿lica de Valparai¿so, Chile.Project fundingThis project is funded through the first research competition of the Joint Canada-Israel Health Research Initiative. The Initiative is a collaboration between the Azrieli Foundation, the Canadian Institutes of Health Research, the Israel Science Foundation, and Canada's International Development Research Centre.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
McMaster University
|
|
|
|
65677596212eaade2e0e1f75
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
2015008191
|
108191
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0109043
|
0
|
0
|
0
|
0.0109043
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
PROFILING EIF2A-DEPENDENT TRAN...SLATION IN SYNAPTIC PLASTICITY AND MEMORY
more
|
Profiling eIF2a-Dependent Tran...slation in Synaptic Plasticity and Memory
more
|
This project will provide evid...ence to help direct treatment strategies in patients with memory deficits and reduce the symptoms associated with Alzheimer's disease.Addressing mental and neurological disordersThe World Health Organization (WHO) recently said that traditional epidemiological methods have seriously underestimated the global burden of mental and neurological disorders. These methods, according to the WHO, are biased toward mortality and they disregard disability rates. Learning, memory, and perception rely on an intricate network of proteins that orchestrate the human brain's higher cognitive functions. Protein synthesis, also known as translation, is an important biological process that regulates the function of these molecules. Dysregulation of translation leads to pathological conditions such as Alzheimer's disease, Parkinson's disease, motor neuron disease, Huntington's disease, and prion diseases (which are spongiform encephalopathies, such as bovine spongiform encephalopathy and Creutzfeldt-Jakob disease). A key molecule regulating protein synthesis is eIF2. Recent studies have shown that modulation of eIF2 activity can enhance learning and memory. Knowledge gained from this project has the potential to direct treatment strategies targeting eIF2 in patients with memory deficits to alleviate the cognitive and neurological symptoms associated with Alzheimer's.Project objectivesThe project aims to:-understand a key molecule regulating protein synthesis and its target mRNAs in synaptic plasticity and memory formation-implement a multi-approach study using genetic, biochemical, behavioural, electrophysiological, and super resolution imaging-further develop the graduate training environment and international research collaborationProject leadershipThe project lead is Nahum Sonenberg at McGill University, Canada. His collaborators are Kobi Rosenblum, University of Haifa, Israel, and Deepak Nair,Indian Institute of Science, Bangalore.Project fundingThis project is funded through the first research competition of the Joint Canada-Israel Health Research Initiative. The Initiative is a collaboration between the Azrieli Foundation, the Canadian Institutes of Health Research, the Israel Science Foundation, and Canada's International Development Research Centre.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
The Royal Institution for the ...Advancement of Learning/McGill University
more
|
|
|
|
65677596212eaade2e0e1f76
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
2015008192
|
108192
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0180987
|
0
|
0
|
0
|
0.0180987
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
CIRCUIT FORMATION BY SPATIO-TE...MPORAL CONTROL OF MESSENGER RNA TRANSLATION
more
|
Circuit Formation by Spatio-Te...mporal Control of Messenger RNA Translation
more
|
The connections inside the bra...in need to be wired in a precise manner during development to ensure its proper function. This project will provide insight into circuit formation to help us understand how axon regeneration can improve clinical outcomes. Brain wiring, damage, and developmental defects Researchers have suggested that improper wiring of the nervous system is the basis for some neurodevelopmental defects. What are the mechanisms that guarantee the proper wiring between the billions of neurons during brain development? Molecules in the extracellular environment, called guidance cues, guide axons to their targets. These cues can be attractive, pulling axons in the right direction, or repulsive, which means they prevent axons from navigating to incorrect targets. Other conditions in which axons need to navigate in adults include regeneration after mechanical or degenerative stimuli, such as a spinal cord injury. Proper regeneration in adults is still a significant clinical problem. Project objectives This research project aims to: -generate a comprehensive picture of the molecular mechanisms underlying the nervous system's wiring -identify novel strategies to promote the proper guidance and wiring of the nervous system -further develop the graduate training environment and international research collaboration among the partners This work will shed new light on the mechanisms that govern the wiring of the nervous system and their role in axon regeneration. It could help to identify novel strategies to promote proper guidance and wiring in the neural circuits of abnormally developing axons, or damaged and regenerating axons. Project leadership The project lead is Fre¿de¿ric Charron at l'Institut de recherches cliniques de Montre¿al, Universite¿ de Montre¿al, Canada. His collaborators are Avraham Yaron, Weizmann Institute of Science, Israel, and Felipe A. Court, Universidad de Chile. Project funding This project is funded through the first research competition of the Joint Canada-Israel Health Research Initiative. The Initiative is a collaboration between the Azrieli Foundation, the Canadian Institutes of Health Research, the Israel Science Foundation, and Canada's International Development Research Centre.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Institut de recherches cliniqu...es de Montréal
more
|
|
|
|
65677596212eaade2e0e1f77
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
2016008405
|
108405
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0304647
|
0
|
0
|
0
|
0.0304647
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
THE TWO FACES OF ENDOGENOUS DN...A EDITING ENZYMES: PROMOTING GENE MUTATIONS AS WELL AS GENOME REPAIR
more
|
The two faces of endogenous DN...A editing enzymes: Promoting gene mutations as well as genome repair
more
|
Type B lymphocytes are a speci...fic type of white blood cell within our immune system. They produce and export antibodies which seek out, attach to, and neutralize microbes and toxins. A unique way that B lymphocytes boost their antibody response is through making changes in the genes that encode for antibodies. These genetic changes in B lymphocytes are carried out by AID, an enzyme that alters the sequence of antibody genes, leading to improved antibodies and hence improved immunity. However, AID activity is often misdirected to the wrong genes, or mis-expressed in the wrong cell types. This results in genetic mutations that can transform healthy cells into cancers. As a result, AID is now recognized as a leading cause of aggressive lymphoma/leukaemia and several solid tissue tumours. Furthermore, continued AID activity in cancer cells increases their ability to mutate and therefore become resistant to therapeutic approaches. Thus, the current scientific belief is that AID causes mutations to the genome of cells which in turn results in causing and/or exacerbating cancer. Strong preliminary data hints at the possibility of a completely new aspect of AID activity: DNA damaged by external sources such as radiation can itself attract AID and this may serve to correct/repair some of the damage. The aim of this project is to study the extent and mechanisms of this effect, and investigate whether it represents a possible pathway by which cancer cells can evade or become resistant to chemotherapy or radiation therapy, since many cancer therapies work through inducing DNA damage. The results of this project may have important implications for cancer treatment strategies.The project is led in Canada by Memorial University of Newfoundland in collaboration with the Hebrew University of Jerusalem (Israel) and researchers from Pakistan and India. It was selected and approved for funding through the second research competition of the Joint Canada-Israel Health Research Program, which is a partnership between Canada's International Development Research Centre, the Canadian Institutes for Health Research, the Israel Science Foundation and the Azrieli Foundation. This seven-year, $35M Canadian-Israeli effort draws on the unique scientific strengths of both countries and facilitates networking opportunities with peers from Africa, Asia, and Latin America. Projects include a plan for integrating researchers from low- and middle-income countries that will establish long-term scientific relationships.
more
|
|
12182
|
Medical research
|
3
|
I.2.a. Health, General
|
51000
|
University, college or other t...eaching institution, research institute or think-tank
more
|
Memorial University of Newfoun...dland
more
|
|
|
|
65677596212eaade2e0e1f78
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
2017008617
|
108617
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.00281974
|
0
|
0
|
0
|
0.00281974
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
SUPPORTING THE COMMUNICATION A...ND DISSEMINATION OF RESEARCH ON WOMEN'S, CHILDREN, AND ADOLESCENT HEALTH
more
|
Supporting the communication a...nd dissemination of research on women's, children, and adolescent health
more
|
The health of women, children,... and adolescents is a key Canadian government development priority. It is also part of the global Sustainable Development Goals (SDG). In alignment with these global priorities, the Maternal and Child Health program is supporting a rich portfolio of implementation research projects that work towards improving the quality, accessibility, and accountability of health services in low and middle-income countries (LMIC).Building on this strong foundation of research, IDRC is exploring new frontiers by supporting complementary research efforts around health information systems and adolescent sexual and reproductive health and rights, with a focus on populations in fragile contexts in West Africa, North Africa, and the Middle East. IDRC's approach has been to support LMIC researchers, policymakers and implementers in a participatory manner, to facilitate opportunities to influence national, regional, and global agendas through strategic convening and dialogues, and to use and disseminate research results.This project aims to communicate the strategic priorities of the program, and to disseminate research results of supported projects to produce greater visibility and reach for impact. A suite of engaging communication products will be developed through this fund to disseminate research results, and to enable the strategic involvement of IDRC grantees in key events to promote knowledge exchange and to influence policies, practices, agendas, and funding priorities. Funds will also support knowledge translation activities that arise, such as grantee engagement in high-level meetings and events, to take advantage of opportunities that enable the mobilization of knowledge into policy processes.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
3
|
I.2.a. Health, General
|
11000
|
Donor Government
|
International Development Rese...arch Centre/Centre de recherches pour le développement international/C
more
|
|
|
|
65677596212eaade2e0e1f79
|
2019
|
Canada
|
International Development Rese...arch Centre
more
|
2017008640
|
108640
|
3
|
Developing countries, unspecif...ied
more
|
Regional and Unspecified
|
Part I unallocated by income
|
ODA Grants
|
1
|
10
|
110
|
C01
|
0
|
0.0676714
|
0
|
0
|
0
|
0.0676714
|
0
|
|
|
|
Sector-wide health programmes
|
Sector-wide health programmes ...Research and Development
more
|
100
|
REPRODUCTIVE, MATERNAL, NEWBOR...N, CHILD & ADOLESCENT HEALTH IN CONFLICT SETTINGS: CASE STUDIES TO INFORM IMPLEMENTATION OF INTERVENTIONS
more
|
Reproductive, maternal, newbor...n, child & adolescent health in conflict settings: case studies to inform implementation of interventions
more
|
This research project will con...tribute to evidence from four country case studies in Syria, South Sudan, Mali, and Colombia or the Democratic Republic of Congo as part of a global project to inform developing operational guidance on interventions related to reproductive, maternal, newborn, child, and adolescent health (RMNCAH) in conflict settings. The objectives of this project are to understand how decisions on RMNCAH interventions in conflict settings are reached; the gaps in service provision and in the populations reached; and the impact of such interventions, including intervention delivery strategies. The project will be conducted by a global academic research consortium led by the SickKids Hospital's Centre for Global Child Health (Canada) in collaboration with local academic and implementation partners. The outcomes include a set of five papers in an early 2019 issue of The Lancet that will synthesize findings from across this global project and will be launched at the International Congress of Pediatrics in March 2019. There will be other venues of dissemination, including conferences, symposia, and in-country dissemination of findings.
more
|
|
12110
|
Health policy and administrati...ve management
more
|
5
|
I.2.a. Health, General
|
22000
|
Donor country-based NGO
|
Hospital for Sick Children
|
|
|
