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After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge
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s of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC50 of around 1 µM against Trypanosoma brucei and is more than 100-fold less toxic to mammalian cells. In the mouse model, fexinidazole cures both the first, haemolymphatic, and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in the Democratic Republic of the Congo demonstrated that oral fexinidazole is safe and effective for use against first- and early second-stage sleeping sickness. Based on the positive opinion issued by the European Medicines Agency in 2018, the WHO has released new interim guidelines for the treatment of HAT including fexinidazole as the new therapy for first-stage and non-severe second-stage sleeping sickness caused by Trypanosoma brucei gambiense (gHAT). This greatly facilitates the diagnosis and treatment algorithm for gHAT, increasing the attainable coverage and paving the way towards the envisaged goal of zero transmission by 2030.
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Evidence from two pilot projects in India.
A guide for developing a hygiene promotion program to increase handwashing with soap
RBM Partnership to End Malaria
recommended
The RBM Partnership to End Malaria is a global coalition comprising over 500 partners, including governments, international organisations, the private sector and civil society, who are all dedicated
...
to ending malaria worldwide. Through coordinated advocacy, resource mobilisation and technical support, the Partnership strengthens national malaria control programmes and accelerates progress towards malaria elimination.
more
Journal of the International AIDS Society 2016, 19:20926
There is a growing interest in the potential contribution the private sector can make towards increasing access to antiretroviral therapy (ART) in low‐ and middle‐income settings. Thi ... s article describes a public–private partnership that was developed to expand HIV care capacity in Yangon, Myanmar. The partnership was between private sector general practitioners (GPs) and a community‐based non‐governmental organization (International HIV/AIDS Alliance).
https://doi.org/10.7448/IAS.19.1.20926 more
There is a growing interest in the potential contribution the private sector can make towards increasing access to antiretroviral therapy (ART) in low‐ and middle‐income settings. Thi ... s article describes a public–private partnership that was developed to expand HIV care capacity in Yangon, Myanmar. The partnership was between private sector general practitioners (GPs) and a community‐based non‐governmental organization (International HIV/AIDS Alliance).
https://doi.org/10.7448/IAS.19.1.20926 more
Guidance on Implending Publi-Private Mix Approaches
The consortium is an international public-private partnership that aims to reduce the global disease burden of schistosomiasis by addressing the medical needs of infected children between the ages o
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f 3 months and 6 years. By doing so, we hope to contribute to the ongoing efforts to eliminate schistosomiasis and improve child health.
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This report outlines the coordination and partnership between two key ministries (Education and Public Health) in Kenya, other line ministries, the private sector, NGOs and the community in implemen
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ting the first phase of a sub-national school-based deworming exercise. The areas targeted included Coast, Central, Western, Nyanza
and parts of Eastern provinces, covering over 45 districts in this first phase. The SBD programme is guided by the National School Health Policy and Guidelines launched in 2009.
more
The Pediatric Praziquantel Consortium was founded in July 2012 as the first international, non-profit, public-private partnership in schistosomiasis, supported by world leading experts in tropical p
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arasitic infectious diseases.
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The Global Schistosomiasis Alliance
The Global Schistosomiasis Alliance (GSA) is an all-inclusive coalition to mobilise the growing momentum to control and eliminate schistosomiasis. It is constituted as a diverse but representative partnership o
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f public health programmes, academic and research institutions, international development agencies and foundations, non-governmental organizations, private sector companies and advocacy and resource-mobilisations partners. Our alliance is not limited to partner organizations but also includes individuals, research groups and different networks, collaborating together as a community to control and eliminate schistosomiasis.
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Growing evidence indicates that large proportions of children around the world experience physical, sexual and emotional violence every year, with enormous implications for human rights, public health and economic and social development.1 Over the last five years, national governments and Together f
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or Girls – a global public-private partnership comprising UNICEF,
other United Nations (UN) agencies, the United States (US) Government and various private sector agencies – have worked to mobilize and sustain a global movement to end violence against children, with a focus on sexual violence against girls.
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Through public-private partnerships, the government of Rwanda can make more efficient use of public resources by targeting and meeting the needs of specific populations and thus help ensure family planning services and products will be available to
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all Rwandans in the long term. This report aims to inform stakeholders working to strengthen family planning through multisectoral partnerships about Rwanda’s family market.
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This working paper aims to provide a rough over-view of existing rules and guidelines on the coopera-tion between the UN and the private sector – at least as they are publicly available. It will describe com-mon features and discus
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s advances and shortcomings of the most prominent and debated rules and guide-lines. Finally, it will present proposals for improve-ment of the existing rules and steps towards a new regulatory and institutional framework for interac-tion between the UN and the private sector.
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Private sector engagement opens pathways for a game-changing US$2 billion investment opportunity in the fight against HIV, tuberculosis and malaria.
PMTCT private sector engagement
SAATHII (Solidarity and Action Against The HIV Infection in India); Elizabeth Glaser Pediatric AIDS Foundation
(2019)
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Accessed: 30.10.2019
Guidelines for Accreditation of private health facilities in Providing SBA Training
Maternal Health Division Ministry of Health and Family Welfare Government of India
Maternal Health Division Ministry of Health and Family Welfare Government of India
(2009)
C1
Reference Manual for Programme Managers on Accreditation Process
