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Diagnosis and Clinical Management of Chagas Disease: An Increasing Challenge in Non-Endemic Areas

Suárez, C., Nolder, D., García-Mingo, A. et al. Research and reports in tropical medicine (2022) CC
Research and Reports in Tropical Medicine 2022:13 25–40. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central, South America, Mexico and the South of the United States. It is an important cause of early mortality and morbidity, and it is associated with po... more
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Preferred Practices for Zithromax® Mass Drug Administration

International Coalition for Trachoma Control ICTC (2013) CC
Countries, partners, and donors are committed to the global elimination of blinding trachoma by 2020. Achieving this public health milestone requires more than funding; it requires health personnel with the right mix of skills, and well supported and managed health systems. Mass drug administratio... more
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First meeting of the network on Buruli ulcer PCR laboratories in the WHO African Region Centre Pasteur du Cameroon, Yaoundé, 21–24 October 2019

World Health Organization WHO (2020) CC
Research to develop point-of-care tests is in progress. Treatment of Buruli ulcer comprises 8 weeks of combined antibiotics (rifampicin and clarithromycin). Complementary therapies such as wound care, skin graft and prevention of disability are needed in some cases to ensure full recovery. The targ... more
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Bench aids for the diagnosis of intestinal parasites 2nd edition
recommended

World Health Organization WHO (2019) C_WHO
2nd edition
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Packages of Care for Depression in Low- and Middle- Income Countries

Patel V, Simon G, Chowdhary N, Kaaya S, Araya R (2009) CC
PLoS Med. 2009 Oct;6(10):e1000159. doi: 10.1371/journal.pmed.1000159. Epub 2009 Oct 6.
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Packages of Care for Schizophrenia in Low- and Middle- Income Countries

J. de Jesus Mari, D. Razzouk, R. Thara, et al. (2009) CC
PLoS Medicine Vol. 6 no. 10 (2009) e1000165
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Diagnostic test for surveillance of lymphatic filariasis: target product profile

World Health Organization WHO (2021) C_WHO
The purpose of this TPP is to communicate the minimum and ideal characteristics desired to meet the need for discriminating low levels of risk for transmission, i.e. targeted prevalence thresholds in the surveyed areas. An in vitro diagnostic test is needed for the detection of analyte(s) specific t... more
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Target product profile for a rapid test for diagnosis of Buruli ulcer at the primary health-care level

World Health Organization WHO (2022) C_WHO
In 2009, WHO’s Second International Conference on Buruli Ulcer Control and Research resolved to strengthen the capacity of national laboratories to confirm cases of the disease, but advised that “efforts are still needed to develop simple diagnostic tools usable in the field as well as disabilit... more
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Core components, concepts and strategies for parasitic and vector-borne disease elimination with afocus on schistosomiasis: A landscape analysis

Monnier, N.; IT. Barth-Jaegg, S. Knopp, et al. (2020) CC
PLoS Negl TropDis14(10): e0008837. https://doi.org/ 10.1371/journal.pntd.0008837. We conducted alandscape analysis on parasitic and vector-borne disease elimination approaches with the aim toidentify evidence-based strategies, core components and key concepts for achieving and sustaining schistosom... more
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Schistosomiasis diagnosis: Challenges and opportunities for elimination

Ally O, Kanoi BN, Ochola L, et al. (2024) CC
PLoS Negl Trop Dis 18(7): e0012282. This review highlights common diagnostic approaches for detecting schistosomiasis in field and clinical settings, major challenges, and provides new and novel opportunities and diagnosis pathways that will be critical in sup- porting elimination of schistosomi... more
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Diagnostic test for lymphatic filariasis to support decisions for stopping triple-therapy mass drug administration: target product profile

World Health Organization WHO (2021) C_WHO
TARGET PRODUCT PROFILE
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Target product profile for a test for rhodesiense human African trypanosomiasis diagnosis usable in peripheral health facilities

World Health Organization WHO (2021) C_WHO
The development of this target product profile (TPP) was led by the WHO Department of Control of Ne- glected Tropical Diseases (NTD) following standard WHO guidance for TPP development. In order to identify and prioritize diagnostic needs, a WHO NTD Diagnostics Technical Advisory Group (DTAG) was... more
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A combined effort of 11 laboratories in the WHO African region to improve quality of Buruli ulcer PCR diagnosis: The “BU-LABNET”

Marion E, Hycenth N, Vedithi SC, et al. (2024) CC
PLoS Negl Trop Dis 16(11): e0010908. https://doi.org/10.1371/journal.pntd.0010908
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Target product profile for a gambiense human African trypanosomiasis individual test to assess infection in low prevalence settings

World Health Organization WHO (2022) C_WHO
HAT diagnosis relies on laboratory techniques because clinical signs and symptoms are unspecific. Serodiagnostic tests exist only for Tbg and are based on the detection of specific antibodies, thus they are not confirmatory of infection. With the current low disease prevalence, the positive predicti... more
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Target product profile for a gambiense human African trypanosomiasis high-throughput test for verification of elimination

World Health Organization WHO (2022) C_WHO
HAT diagnosis relies on laboratory techniques because clinical signs and symptoms are unspecific. Serodiagnostic tests exist only for Tbg and are based on the detection of specific antibodies, thus they are not confirmatory of infection. With the current low disease prevalence, the positive predicti... more
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Human African trypanosomiasis cases diagnosed in non-endemic countries (2011– 2020)

Franco. J.R.; G. Cecchi, G. Priotto, et al. (2022) CC
PLoS Negl Trop Dis 16(11): e0010885. https://doi.org/10.1371/journal.pntd.0010885 HAT diagnosis in non-endemic countries is rare and can be challenging, but alertness and surveillance must be maintained to contribute to WHO’s elimination goals. Early detection is particularly important as it co... more
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Preventive chemotherapy diseases and transmission control Ghana

World Health Organization (2010) C_WHO
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Dengue: falling between the cracks

Malaria Consortium (2016) C1
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HIV, Food Security and Nutrition

UNAIDS (Joint United Nations Programme on HIVAIDS); World Health Organization; WFP World Food Programme (2008) C2
Policy Brief
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Sleeping sickness : human African trypanosomiasis

World Health Organisation WHO (1997) C_WHO
Comic