Malaria
TOOLBOX

The MALARIA TOOLBOX is a comprehensive knowledge repository designed to support effective interventions aimed at tackeling Malaria worldwide. Malaria remains one of the most significant infectious diseases, posing a major public health challenge particularly in tropical and subtropical regions. Literature on malaria is essential for understanding its epidemiology, prevention strategies, diagnostic methods, and treatment options. 

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The following appendices of the Guide for introducing a malaria vaccine containing key messages are available for country adaptation
Guide pour l’introduction du vaccin contre le paludisme dans les programmes nationaux de vaccination Messages clés sur la vaccination antipaludique à adapter par les pays Annexe 1. Informations sur le vaccin contre le paludisme destinées aux agents de santé (pour l’introduction du vacci ... more
Technical Report
Two malaria vaccines are currently WHO prequalified and recommended1 for use to prevent P. falciparum malaria in young children, the RTS,S/AS01 vaccine, currently manufactured by GlaxoSmithKline (GSK), and the R21/Matrix-M vaccine, manufactured by Serum Institute of India Pvt (SII)
Deux vaccins antipaludiques sont actuellement préqualifiés et recommandés par l'OMS1 pour prévenir le paludisme à P. falciparum chez les jeunes enfants : le vaccin RTS,S/AS01, actuellement fabriqué par GlaxoSmithKline (GSK), et le vaccin R21/Matrix-M, fabriqué par Serum Institute of India ... more
Lancet Microbe 2024; 5: e519
Lancet 2024; 403: 533–44 R21/Matrix-M was well tolerated and offered high efficacy against clinical malaria in African children. This low-cost, high-efficacy vaccine is already licensed by several African countries, and recently received a WHO policy recommendation and prequalification, offerin ... more
WHO position paper on malaria vaccines, Weekly Epidemiological Record 10 May 2024
The WHO susceptibility test kit has been extensively used for monitoring of insecticide resistance in disease vectors for many years. Over the years, users have reported issues with these kits and potential improvements to WHO in an ad-hoc manner. To systematically determine whether the reported iss ... more
Video
The aim of this protocol is to support the conduct of entomological comparative efficacy assessments for vector control products and the associated non-inferiority analysis. This evidence is used to inform discussions within the guidelines development context as to whether a new vector control prod ... more
Malar J 23, 333 (2024). https://doi.org/10.1186/s12936-024-05165-w. Prioritization of spending on prevention, anti-malarial medicines, and health systems strengthening can fight incident cases and fatalities simultaneously, especially in resource-scarce, malaria-endemic countries. Furthermore, imp ... more
This WHO guidance outlines reactive strategies to interrupt malaria transmission in areas nearing elimination or to prevent re-establishment, triggered by confirmed cases.
The purpose of the guideline is to provide information to stakeholders on the necessary requirements for a complete prequalification dossier for insecticide-treated nets (ITNs). Its aim is to establish the baseline for dossier requirements which are necessary to assess ITN products for the purposes ... more
Medicine 2024;103:29(e39010. This review underscores the urgency of adapting to the changing landscape of malaria transmission driven by climate change. It emphasizes the significance of proactively addressing climate-related challenges to enhance malaria control and protect the health and well-bein ... more
This paper is the first quantitative analysis of how the impact of extreme weather events, such as floods and cyclones, affects the malaria burden on the continent, as well as the implications of long-onset climate change. This research involved developing a climate model to predict changes in inten ... more
Reprogramming examples for GC7. This document supports the introduction of climate change-related interventions into programs to reduce transmission of malaria and protect vulnerable populations.
Thematic brief. Climate change and malaria are two defining challenges of our generation. Both affect disproportionately the poorest and the most vulnerable, especially in Africa, and may further jeopardize human wellbeing in the future
Note d'orientation
In recent decades we have seen progressive changes to global climate patterns caused by anthropogenic impacts on the environment. These are likely to directly and indirectly affect human health, and are projected to continue and potentially accelerate into the future. Neglected tropical diseases (N ... more