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Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

Ana Maria Henao-Restrepo, Ira M Longini, Matthias Egger, et al. (2015)
the Lancet : Published Online July 31, 2015 http://dx.doi.org/10.1016/S0140-6736(15)61117-5
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Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

Henao-Restrepo, A.M.; et al. (2016)
The Lancet. Published Online December 22, 2016 http://dx.doi.org/10.1016/S0140-6736(16)32621-6. Open Access
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Efficacy of isoniazid prophylactic therapy in prevention of tuberculosis in children: a meta–analysis

J. Ayieko, L. Abuogi, B. Simchowitz, et al. BMC Infectious Diseases (2014) CC
Research Article BMC Infectious Diseases 2014, 14:91/1471-2334/14/91
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Efficacy of corticosteroids in patients with COVID-19 pneumonia - based on information as at 12 June 2020

World Health Organization WHO; Regional Office for Africa (2020) C_WHO
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Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig G, Bernhard SC, Blum J, Burri C, Mpanya A, PLOS Neclected Tropical Diseases (2016) CC
This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospita ... more
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Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Côte d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised

Hoekstra P.T., Casacuberta-Partal M., van Lieshout L. et al (2020) C2
Preventive chemotherapy with praziquantel (PZQ) is the cornerstone of schistosomiasis control. However, a single dose of PZQ (40 mg/kg) does not cure all infections. Repeated doses of PZQ at short intervals might increase efficacy in terms of cure r ... more
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Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial

Bosch-Nicolau, P.; (2024) CC
Lancet Infectious Disease Volume 24, Issue 4p386-394April 2024
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Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea

Marks, M.; O. Mitja; C. Bottomley, et al. (2018) CC
n this study, low-dose azithromycin did not meet the prespecified non-inferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws. Only a single participant (with presumed latent yaws) had definitive serological failure. This wo ... more
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Therapeutic efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in a high-transmission area in northwest Ethiopia

Teklemariam M., Assefa A., Kassa M., et al. Plos One (2017) C1
Published: April 26, 2017 https://doi.org/10.1371/journal.pone.0176004
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Vaccine efficacy, effectiveness and protection

World Health Organization WHO (2021) C_WHO
14 July 2021 This article is part of a series of explainers on vaccine development and distribution. Learn more about vaccines – from how they work and how they’re made to ensuring safety and equitable access – in WHO’s Vaccines Explained series. COVID-19 vaccines have proven to be safe, ... more
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Preliminary results on the efficacy of rVSV-ZEBOV-GP Ebola vaccine using the ring vaccination strategy in the control of anEbola outbreak in the Democratic Republic of the Congo

World Health Organization WHO (2019) C_WHO
An example of integration of research into epidemic response.
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Report on antimalarial drug efficacy, resistance and response: 10 years of surveillance (2010-2019)

World Health Organization WHO (2020) C_WHO
Antimalarial drug resistance has emerged as a threat to global malaria control efforts, particularly in the Greater Mekong subregion. Drawing on data collected through more than 1000 therapeutic efficacy studies as well as molecular marker studies o ... more
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

Polack, F.P. et al. (2020) CC
This article was published on December 10, 2020, and updated on December 16, 2020, at NEJM.org. DOI: 10.1056/NEJMoa2034577
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Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Logunov, D.Y, et al. (2021) C1
Published:February 02, 2021DOI:https://doi.org/10.1016/S0140-6736(21)00234-8
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Statement on the Efficacy of the AstraZeneca COVID-19 Vaccine (ChAdOx1 nCoV-19) against the SARS-CoV-2 Variants
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2021) C1
On the 9 February 2021, Africa CDC convened a special session of the Africa Task Force for COVID-19 to review existing data and evidence and recommend
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Malaria chemoprevention efficacy study protocol

World Health Organization WHO (2022) C_WHO
Chemoprevention is the use of medicines, either alone or in combination, to prevent malaria infection and its consequences. This publication provides standardized approaches for monitoring and evaluating the efficacy of medicines used for intermitte ... more
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Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double- blind, randomised, phase 3 trial

Datoo, M.S.; A. Dicko, H.Tinto, et al. (2024) CC
Lancet 2024; 403: 533–44 R21/Matrix-M was well tolerated and offered high efficacy against clinical malaria in African children. This low-cost, high-efficacy vaccine is already licensed by sever ... more
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Safety and efficacy of long-acting injectable lenacapavir as pre-exposure prophylaxis to reduce the risk of HIV acquisition: a systematic review
recommended

World Health Organization WHO (2025) C_WHO
Guidelines on lenacapavir for HIV prevention and testing strategies for long-acting injectable pre-exposure prophylaxis. Web Annex B
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Artemisinin resistance and artemisinin-based combination therapy efficacy

World Health Organization (WHO) (2018) C_WHO
The reports bring together the latest findings and conclusions about the state of resistance to artemisinins and artemisinin-based combination therapy (ACT), summarize WHO’s current policy and treatment recommendations, and highlight areas of concern.
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Oxford–AstraZeneca COVID-19 vaccine efficacy

Knoll, M.D.; and C. Wonodi (2021) CC
Comment The Lancet Volume 397, ISSUE 10269, P72-74, January 09, 2021 Published:December 08, 2020DOI:https://doi.org/10.1016/S0140-6736(20)32623-4