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Marks, M.; O. Mitja; C. Bottomley, et al. (2018)   CC

n this study, low-dose azithromycin did not meet the prespecified non-inferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws. Only a single participant (with presumed latent yaws) had definitive serological failure. This work suggests that 20 mg/kg of azithromycin is probably effective against yaws, but further data are needed.

study,  Yaws,  Eradication,  Treatment,  standard dose,  Ghana,  Papua New Guinea,