The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success against HAT and the competing priorities associat...ed with other medical crises ravaging the continent. A series of dedicated interventions and the introduction of innovative routes to develop drugs, involving Product Development Partnerships, has led to a dramatic turnaround in the fight against HAT caused by Trypanosoma brucei gambiense. The World Health Organization have been able to optimize the use of existing tools to monitor and intervene in the disease. A promising new oral medication for stage 1 HAT, pafuramidine maleate, ultimately failed due to unforeseen toxicity issues. However, the clinical trials for this compound demonstrated the possibility of conducting such trials in the resource-poor settings of rural Africa.
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The Lancet Volume 390, Issue 10110p2397-2409November 25, 2017.
Human African trypanosomiasis (HAT), also called sleeping sickness, is a parasitic infection that almost invariably progresses to death, unless treatment is provided. HAT caused devastating epidemics during the 20th century. Thanks to ...sustained and coordinated efforts during the past 15 years the number of reported cases has fallen to a historic low. Fewer than 3,000 cases were reported in 2015, and the disease is targeted for elimination by the World Health Organization. Despite recent success, HAT still poses a heavy burden on the rural communities where this highly focal disease occurs, most notably in Central Africa. Since patients are also reported from non-endemic countries outside Africa, HAT should be considered in differential diagnosis for all travellers, tourists, migrants and expatriates who have visited or lived in endemic areas. In the absence of a vaccine, disease control relies on case detection and treatment, and vector control. Available drugs are sub-optimal, but ongoing clinical trials give hope for safer and simpler treatments.
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Technical Note: Cholera treatment facilities provide inpatient care for cholera patients during outbreaks. Proper case management and isolation of cholera patients is essential to prevent deaths and help control the spread of
the disease. Traditionally, these structures have been referred to as ch...olera treatment centres (CTCs) and
cholera treatment units (CTUs). CTCs are usually large structures set up at central level (e.g. urban areas),
while CTUs are smaller structures set up in the periphery (e.g. peri-urban or rural areas). CTCs/CTUs can
be set up as independent structures in tents or within existing buildings or wards of health structures.
Whatever the structure, the principles described in this document should be respected
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In the year 2008, for the first time in history, more than half of the world’s population was living in urban areas. Cities have become more numerous, more populous, and denser. The complexity and density of urban environments significantly alter the viability of certain humanitarian protection st...rategies that might work well in rural, more sparsely populated areas. In addition, it has become difficult to draw the line between acute and chronic vulnerability and therefore, the identification of beneficiaries. This blur in distinction between chronic and acute vulnerability has raised a number of important questions for humanitarian organizations regarding if and how they should intervene. While many such organizations are equipped with the appropriate skills to mitigate overwhelming public health challenges is such contexts, the absence of a crisis point - such as armed conflict or natural disaster - brings the mandate of humanitarian agencies into question.
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DHS Analytical Studies No. 41
This report considers how to integrate health into urban planning, investments, and policy decisions, so as to support the implementation and achievement of the goals and objectives of the New Urban Agenda.
Neurology Asia 2008; 13 : 41 – 48
Urban health / StadtGesundheit bezeichnet die Anwendung von Public Health -Theorie und - Praxis für die Gesundheit städtischer Bevölkerungen.
This timely report comes at a decisive moment in history where
we can reshape urban environments and health systems for the
majority of the world’s population that live in cities. Enabling
this transformation are the SDGs, which have reconfigured how
governments and the international community... need to plan and
implement actions to eradicate poverty and inequality, create
inclusive economic growth, preserve the planet and improve
population health. Central to this quest is to create equitable,
healthier cities for sustainable development.
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Key populations brief
Accessed 2017
BMC Family Practice (2017) 18:56 DOI 10.1186/s12875-017-0628
DHS WORKING PAPERS 2016 No. 126 | DEMOGRAPHIC AND HEALTH SURVEYS