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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Training Course on the Management of Severe Malnutrition Course Director Guide

WHO WHO (2002)

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A Framework for Integrating Childhood Tuberculosis into Community-based Child Health Care

Detjen A, Gnanashanmugam D, Talens A International Union Against Tuberculosis and Lung Disease (The Union), CORE Group (2013) C_WHO

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Improving Prison Conditions by Strengthening the Monitoring of HIV, HCV, TB and Harm Reduction (Portugal)

N. H. Ponters, A. P. Dores CIES IUL; ISCTE IUL; European Union (2015) C2

Mapping Report - Portugal

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Pharmaceutical management and prescribing pattern of antimalarial drugs in the public health facilities in Dar-es-Salaam, Tanzania

Richard Sebastian Silumbe (2011) C1

Master of Science in Pharmaceutical Management Dissertation

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Epidemic meningitis surveillance in the African meningitis belt

World Health Organization WHO (2014) C_WHO

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WHO Safe Childbirth Checklist Implementation Guide
recommended

World Health Organization WHO (2015) C_WHO

This implementation guide has been developed to help birth attendants and health-care leaders successfully launch and sustain use of the WHO Safe Childbirth Checklist. Development, use and implementation of the Checklist are described in this guide. It covers how to introduce and ensure continuous ... more

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WHO recommendations for prevention and treatment of maternal peripartum infections

World Health Organization WHO (2015) C_WHO

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Tanzania Service Provision Assessement Survey (TSPA) 2014-2015 Key Findings

Ministry of Health and Social Welfare, Dar es Salaam, Ministry of Health, Zanzibar, National Bureau of Statistics, Zanzibar, Tanzania, and ICF International (2016) C1

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Communicable disease threats report, 11 November 2017

European Centre for Disease Prevention and Control (2017) C1

The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period 5-11 November 2017 and includes updates on measles, rubella, chikungunya, West Nile virus, Plague, monkeypox, legionnair... more

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National Strategic Framework for the Elimination of Obstetrics Fistula in Nigeria 2011-2015

Federal Ministry of Health, Nigeria (2012) C1

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India: TRAINING OF Link ART Centre (LAC) COUNSELLORS - HANDBOOK FOR TRAINEES

National AIDS Control Organization (NACO), Ministry of Health and Family Welfare, Government of India (2012) C1

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Namibia Health Facility Census 2009: Key Findings on Family Planning, Maternal and Child Health, and Malaria

Ministry of Health and Social Services (MoHSS), Namibia; ICF Macro, USA (2010) C_WHO

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Tuberculosis prevention, care and control A practical directory of new advances

Stop TB Partnership; World Health Organization ; USAID (2011) C_WHO

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Climate-Smart Healthcare : Low-Carbon and Resilience Strategies for the Health Sector

The World Bank Group (2017) CC

Climate change is damaging human health now and is projected to have a greater impact in the future. Low- and middle-income countries are seeing the worst effects as they are most vulnerable to climate shifts and least able to adapt given weak health systems and poor infrastructure. Low-carbon appro... more

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Treat as One. Bridging the gap between mental and physical healthcare in general hospitals

National Confidential Enquiry into Patient Outcome and Death (2017) C1

This NCEPOD report highlights the quality of mental health and physical health care for patients aged 18 years or older with a significant mental disorder who are admitted to a general hospital. The report takes a critical look at areas where the care of patients might have been improved. Remediable... more

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Atlas of Common Clinical Presentations of Paediatric HIV Infections

Ministry of Health Uganda (2016) C2

Over 2 million children worldwide are living with HIV infection and 95% reside in sub-Saharan Africa with the majority infected through mother-to-child transmission. Infected children have a high mortality with 50% dying by 2 years of age. Their clinical presentation includes common childhood infect... more

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Quality of care for children with severe disease in the Democratic Republic of the Congo

Clarke-Deelder, E., G. Shapira, H. Samaha, et al. (2019) CC

BMC Public Health (2019) 19:1608 https://doi.org/10.1186/s12889-019-7853-3

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The Sustainable Development Goals Report 2022

United Nations (2022) C2

According to the Report, cascading and interlinked crises are putting the 2030 Agenda for Sustainable Development in grave danger, along with humanity’s very own survival. The Report highlights the severity and magnitude of the challenges before us. The confluence of crises, dominated by COVID-19,... more

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Emergency Illnesses and Major Injuries Affecting Infants and Children; Including Adolescent Girls Who Are Pregnant

Maternal & Childhealth Advocacy International MCAI (2021) C1

Handbook 1

WHO Safe Childbirth Checklist Implementation Guide recommended

WHO Safe Childbirth Checklist Implementation Guide
recommended