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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Toolkit on disability for AFRICA: INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) AND DISABILITY

United Nations Division for Social Policy Development (DSPD) & United Nations Department of Economic and Social Affairs (DESA) (2016) C1

Module 12

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Interventions for preventing child abuse

World Health Organization (2012) C_WHO

Q2: What are the effective interventions for preventing child abuse and its mental health consequences?

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WHO's response to Zika virus and its associated complications - Report to donors, December 2016

World Health Organization WHO (2017) C_WHO

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India: TRAINING OF Link ART Centre (LAC) COUNSELLORS - HANDBOOK FOR TRAINEES

National AIDS Control Organization (NACO), Ministry of Health and Family Welfare, Government of India (2012) C1

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Rules of engagement between the UN and private actors - Towards a regulatory and institutional framework

Jens Martens and Karolin Seitz MSEREOR, Brot für die Welt, Global Policy Forum Europe (2019) C2

This working paper aims to provide a rough over-view of existing rules and guidelines on the coopera-tion between the UN and the private sector – at least as they are publicly available. It will describe com-mon features and discuss advances and shortcomings of the most prominent a... more

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Nursing Skills and Procedures - Pocket Guide

Anne Griffin, Patricia A. Potter Elsevir (2015) CC

Mosby’s Pocket Guide to Nursing Skills and Procedures, eighth edition, is a practical, portable reference for students and practitioners in the clinical setting. Grouped alphabetically, 85 commonly performed skills are presented in a clear, step-by-step format that includes: ■ Purpose for pe... more

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More than money — The Joint United Nations Programme on HIV/AIDS and the Global Fund to Fight AIDS, Tuberculosis and Malaria

The Global Fund, UNAIDS UNAIDS (2021) C_WHO

Joint actions by the Global Fund and UNAIDS are guided by a strong alignment of strategies, goals and targets. UNAIDS has worked with all stakeholders to set a common agenda and targets within the Global AIDS Strategy 2021–2026, and the United Nations General Assembly confirmed this strategy and i... more

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Climate change: A hunger crisis in the making - World

Action Against Hunger (2021) C2

English Analysis on World and 3 other countries about Agriculture, Climate Change and Environment, Drought, Flood and more; published on 22 Oct 2021 by Action Against Hunger

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Global competency and outcomes framework for universal health coverage

World Health Organization WHO (2022) C_WHO

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AMR-SORT IT 2021 annual report

World Health Organization WHO; Special Programme for TDR (2022) C_WHO

During the first two years of the project (2019–2020), through a ‘One Health’ approach, comprehensive engagement was established with AMR coordinating committees, WHO regional and country offices and SORT IT partners in Asia, Africa, Europe and the Americas. Thirty-seven research studies were ... more

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Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy

Tirados, I.; Esterhuizen, J.; Kovacic, V.; Mangwiro, TNC.; Vale, GA et al. PLOS Neglected Tropical Diseases (2015) CC

Sleeping sickness is controlled by case detection and treatment but this often only reaches less than 75% of the population. Vector control is capable of completely interrupting HAT transmission but is not used because of expense. We conducted a full scale field trial of a refined vector control tec... more

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Lost at home - The risks and challenges for internally displaced children and the urgent actions needed to protect them

UNICEF (2020) CC

Today, more children than ever before are displaced within their own countries. Their harrowing stories of displacement are unfolding every day, and with increasing frequency. At the end of 2019, approximately 45.7 million people were internally displaced by conflict and violence (Fig. 1.1). Nearly ... more

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India: Leprosy Training Manual For Health Workers and Supervisors

National Leprosy Eradication Programme; National Health Mission; Ministry of Health & Social Welfare India (2014) C1

Course contents: What is Leprosy? Leprosy is a disease caused by a micro-organism called Mycobacterium leprae

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Latrine Design and Construction. Making Culturally-Appropriate Latrines

Lifewater (2011) CC

2nd edition

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IASC Guidelines for mental health and psychosocial support in emergency settings
recommended

Inter-Agency Standing Committee (2007) C1

Specific action sheets offer useful guidance on mental health and psychosocial support and cover the following areas coordination assessment monitoring and evaluation protection and human rights standards human resources community mobilisation and support health services education dissemination of i... more

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Fertilizing Crops to Improve Human Health: A Scientific Review

IPNI, IFA International Plant Nutrition Institute, International Fertilizer Industry Association (2012) C1

- The Role of Plant Nutrition in Supporting Food Security - Micronutrient Malnutrition: Causes, Prevalence, Consequences and Interventions - Fertilizer Application and Nutraceutical Content in Health-Functional Foods - Plant Nutrition and Health Risks Associated with Plant Diseases - Human Heal... more

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HIV and Mobility: Compendium of Migration and HIV and Aids Interventions

Jose Michael International Organization for Migration (IOM) (2009) C_WHO

This publication by UNAIDS, UNDP and the International Organisation for Migration examines various dimensions related to migration and HIV and AIDS.

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Towards disability - inclusive education

Saeboenes, A.-M.; et al. Expert Group on Disability (2015) CC

Background paper for the Oslo Summit on Education for Development. This paper covers the four topics of the Oslo Summit: investment in education, quality of learning, education in emergencies and girls’ education. Disability continues to be one of the primary causes of educational disadvantage a... more

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An Assessment of Available Evidence on NCDs and their Risk Factors in Myanmar

HelpAge International Myanmar, University of Public Health and University of Medicine-2 (2016) C1

Report on Main Findings
The review encompasses three complementary components: 1) a review of published literature 2000-2015 on NCDs and their risk factors; 2) qualitative interviews with key actors engaged in NCD research in Myanmar; and 3) additional reviews of Myanmar ethical committee inqui... more

IASC Guidelines for mental health and psychosocial support in emergency settings recommended

IASC Guidelines for mental health and psychosocial support in emergency settings
recommended