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Effectiveness and cost-effectiveness of group support psychotherapy delivered by trained lay health workers for depression treatment among people with HIV in Uganda

Nakimuli-Mpungu, E.; S. Musisi, K. Wamala, et al. (2020) CC
: a cluster-randomised trial. Lancet Glob Health 2020; 8: e387–98
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Experimental Ebola drugs face tough test in war zone

Maxman, A. (2018) C2
Researchers are devising a clinical-trial protocol to test three medicines in Africa's latest outbreak Nature doi: 10.1038/d41586-018-06132-7
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EFFECTIVENESS OF SHORTENED COURSE (≤ 3 DAYS) OF ANTIBIOTICS FOR TREATMENT OF ACUTE OTITIS MEDIA IN CHILDREN

Gulani, A. & Sachdev, H.P.S World Health Organisation (WHO) (2009) C_WHO
A systematic review of randomized controlled efficacy trials | REPORT - DEPARTMENT OF CHILD AND ADOLESCENT HEALTH AND DEVELOPMENT
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New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story

Dickie, E.A.; Giordani, F.; Gould, M.K.; Mäser, P.; Burri, C.; Mottram, J.C.; Rao, S.P.S.; Barrett, M.P. MDPI Tropical Medicine and Infectious Disease (2020) CC2
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success against HAT and the competing priorities associat... more
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Toolkit for research and development of paediatric antiretroviral drugs and formulations

World Health Organization (WHO); Unitaid; Unicef; et al. World Health Organization (WHO); Unitaid; Unicef; et al. (2018) C_WHO
WHO and UNITAID in collaboration with IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials) network, PENTA (Paediatric European Network for Treatment of AIDS) foundation and experts from the Paediatric Antiretroviral Working Group
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Buruli ulcer: cured by 8 weeks of oral antibiotics?

Johnson, P.D.R. The Lancet Journal (2020) C1
Phillips and colleagues have shown that rifampicin combined with clarithromycin is non-inferior to RS8, and is safer. This much anticipated trial provides us with a high degree of confidence that an 8-week course of oral rifampicin and clarithromycin should now be the cornerstone of the treatment of... more
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Guidelines for laboratory and field testing of molluscicides for control of schistosomiasis

World Health Organization WHO (2019) C_WHO
This document provides up-to-date guidance on laboratory studies as well as smallscale (semi-field) and large-scale field trials to assess the efficacy and determine field application rates of new molluscicide products for control of schistosomiasis.
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Covaxin

Bharat Biotech (2021) CC
COVAXINTM, India's indigenous COVID-19 vaccine by Bharat Biotech is developed in collaboration with the Indian Council of Medical Research (ICMR) - National Institute of Virology (NIV). The indigenous, inactivated vaccine is developed and manufactured in Bharat Biotech's BSL-3 (Bio-Safety Level 3) h... more
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Integrating Clinical Research into Epidemic Response: The Ebola Experience

Gerald Keusch, Keith McAdam, Patricia Cuff, Michelle Mancher, and Emily R. Busta National Academies of Sciences, Engineering, and Medicine (2017) C1
The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Repub... more
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New Therapeutics for Chagas Disease: Charting a Course to Drug Approval

Man, A. & Segal, F. Intechopen (2022) CC
DOI: 10.5772/intechopen.102891Little progress has been made since the 1960s and 19. 70s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and opera... more
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Serious adverse events following treatment of visceral leishmaniasis: A systematic review and meta-analysis

Singh-Phulgenda, S., Dahal, P., Ngu, R. et al. PLOS Neglected Tropical Diseases (2021) C1
Despite a historical association with poor tolerability, a comprehensive review on safety of antileishmanial chemotherapies is lacking. We carried out an update of a previous systematic review of all published clinical trials in visceral leishmaniasis (VL) from 1980 to 2019 to document any reported ... more
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Covid-19 - living NMA initiative

World Health Organization WHO, et al. (2021) C_WHO
As of January 20, 2021 the Covid-19 - living NMA initiative collected 150 RCTs and 36 non-randomised studies of vaccines from the ICTRP. 93 of these trials are recruiting patients.
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AstraZeneca ChAdOx1-S/nCoV-19 [recombinant], COVID-19 vaccine

World Health Organization WHO (2021) C_WHO
10 May 2021. Manufactureres: SK Bioscience Co. Ltd. [COVID-19 Vaccine (ChAdOx1-S [recombinant])] Serum Institute of India Pvt. Ltd. [COVISHIELD™, ChAdOx1 nCoV-19 Corona Virus Vaccine (Recombinant)] The ChAdOx1-S/nCoV-19 [recombinant] vaccine is a replication-deficient adenoviral vecto... more
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Ongoing Living Update of Potential COVID-19 Therapeutics: Summary of Rapid Systematic Reviews. Rapid Review

Pan American Health Organisation PAHO (2020) C_WHO
As of 31 October 2020 This is the tenth edition of this summary of rapid systematic reviews, which includes the results of a rapid systematic review of currently available literature. More than 200 therapeutic options or their combinations are being investigated in more than 1,700 clinical trials. I... more
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How are vaccines developed?

World Health Organization WHO (2021) C_WHO
This article is part two in a series of explainers on vaccine development and distribution. Part one focused on how vaccines work to protect our bodies from disease-carrying germs. This article focuses on the ingredients in a vaccine and the three clinical trial phases. Part three outlines the nex... more
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Statement on the use of Dexamethasone for severely ill COVID-19 Patients

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1
Africa Centers for Disease Control and Prevention (Africa CDC) is aware of the media releases of the preliminary results of a large randomized clinical trial conducted in the United Kingdom, which included dexamethasone, a corticosteroid, as one of the drugs used for the treatment of COVID-19 patien... more
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Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy

Tirados, I.; Esterhuizen, J.; Kovacic, V.; Mangwiro, TNC.; Vale, GA et al. PLOS Neglected Tropical Diseases (2015) CC
Sleeping sickness is controlled by case detection and treatment but this often only reaches less than 75% of the population. Vector control is capable of completely interrupting HAT transmission but is not used because of expense. We conducted a full scale field trial of a refined vector control tec... more
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WHO Living guideline: Drugs to prevent COVID-19
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World Health Organization WHO (2021) C_WHO
Interim guidance 2 march 2021 Current use of drugs to prevent COVID-19 is variable, reflecting large-scale uncertainty. Numerous randomized trials of many different drugs are underway to inform practice. This first version of the Drugs to prevent COVID-19: A WHO living guideline contains new inform... more
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COVID-19 vaccine tracker and landscape
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World Health Organization WHO (2022) C_WHO
The COVID-19 vaccine tracker and landscape compiles detailed information of each COVID-19 vaccine candidate in development by closely monitoring their progress through the pipeline. The COVID-19 vaccine tracker: Provides summary tables of COVID-19 vaccine candidates in both clinical and pre-... more
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A triple-drug treatment regimen to accelerate elimination of lymphatic filariasis: From conception to delivery

G. J. Weil; Jacobson, J. A.; King J. D. International Health (2020) CC
The Global Programme to Eliminate Lymphatic Filariasis (LF) is using mass drug administration (MDA) of antifilarial medications to treat filarial infections, prevent disease and interrupt transmission. Almost 500 million people receive these medications each year. Clinical trials have recently shown... more