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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Vector control interventions designed to control malaria in complex humanitarian emergencies and in response to natural disasters

World Health Organization WHO (2021) C_WHO

“Preferred product characteristics” (PPCs) are key tools to incentivize and guide the development of urgently needed health products. Some of the vector control interventions deployed in complex emergencies and in response to natural disasters – namely insecticide-treated nets (ITNs) and indoo... more

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Antimicrobial Stewardship Program Guideline (India)
recommended

Balaji, V., P. Rupali, K. Walia, et al. Indian Council of Medical Research (2018) C2

Antimicrobial resistance (AMR) is a major public health challenge, which is recognized as high priority area by the Government of India. The increasing consumption of antibiotics is one of the key drivers of antimicrobial resistance seen in bugs of public health importance. Irrational prescription o... more

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"The greatest need was to be listened to": The importance of mental health and psychosocial support during COVID-19

International Federation of Red Cross and Red Crescent Societies (IFRC) (2020) C1

Experiences and recommendations from the International Red Cross and Red Crescent Movement. Measures imposed by governments to prevent the spread of the disease, including lockdown restrictions, quarantines, physical distancing, and their economic and social consequences, further increase this dist... more

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Education, Ethnicity and Reproductive Practice in Cameroon

Johnson-Hanks J. persee (2003) C1

It is often observed that educated women have lower birth rates than do the less educated, inviting a causal interpretation. However, educated women also differ from those who have never attended school in a variety of other ways: the two factors are multiply related. This article analyzes the rela... more

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Zika virus disease epidemic: Preparedness planning guide for diseases transmitted by Aedes aegypti and Aedes albopictus

European Centre for Disease Prevention and Control (2016) C1

The threat posed by Zika virus infection highlights the need to reinforce preparedness arrangements for mosquito-borne diseases in EU/EEA countries, especially for pathogens transmitted by Aedes aegypti and Aedes albopictus. The aim of this document is to highlight measures that can effectively red... more

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Management & Post-Exposure Prophylaxis of Potential HIV and Hepatitis B Exposure in Children, Adolescents & Adults Guidelines (South Africa)

Western Cape Government Health, South Africa (2019) C1

1PEP GUIDELINES | 2019 EDITION. The prevalence of both HIV and Hepatitis B is high in South Africa therefore there is a significant risk of acquiring these infections following exposure to infected material. Studies suggest that post- exposure prophylaxis (PEP) with highly active antiretroviral trea... more

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Operational framework for building climate resilient health systems

World Health Organization WHO (2017) C_WHO

The framework responds to the demand from Member States and partners for guidance on how the health sector and its operational basis in health systems can systematically and effectively address the challenges increasingly presented by climate variability and change. This framework has been designed ... more

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Interim Guidance on the Use of Rapid Antigen tests for COVID-19 Response
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1

16 Dec. 2020 This document provides guidance to Ministries of Health (MOHs), laboratory personnel and implementing partners in African Union Member States on the application of rapid antigen tests to COVID-19 testing. The guidance serves as reference for policymakers, laboratory leads, implementing... more

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Gap Analysis: the Inclusion of People with Disability and Older People in Humanitarian Response

Pryor, W.; M. Marella and A. Robinson Humanitarian Innovation Fund HIF; ELRHA (2020) C1

Part 2: Part 2 Beyond the evidence: Implications for innovation and practice Part 2 of the Gap Analysis presents the insights from individuals working in humanitarian response, disability inclusion and older age inclusion. This report begins by looking at how an agenda for the inclusion of people ... more

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Guidelines for the implementation of non-pharmaceutical interventions against COVID-19

European Centre for Disease Prevention and Control ECDC (2016) C1

Non-pharmaceutical interventions (NPI) are public health measures that aim to prevent and/or control SARS-CoV-2 transmission in the community. As long as there is no effective and safe vaccine to protect those at risk of severe COVID-19, NPI are the most effective public health interventions against... more

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Shelter Safety Handbook
recommended

The International Federation of Red Cross and Red Crescent Societies IFRC (2011) CC

This handbook presents some basic information on safe construction practices. Its purpose is to provide guidance on choices regarding settlement planning in risky environments, as well as on the building techniques to improve individual shelters. The contents may be used to develop trainings on part... more

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Community early warning systems: guiding principles

International Federation of Red Cross IFRC (2020) C1

This guide aims to provide an overview of successful practice from the field for the disaster risk reduction/management practitioner interested in EWS. It presents guiding principles that will build a strong foundation for the design or strengthening of EWS at any level. It is not an operational, bu... more

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Clinical management of rape and intimate partner violence in emergencies: training curriculum for health workers, facilitator guide: web annex B: participant job aids

World Health Organization WHO (2025) C_WHO

The training you receive will give you the tools you need to feel confident about broaching the subject with your patients. Reviewing the materials the job aids, especially job aids 4a and 7a, can help refresh your knowledge in the months and years ahead. Remember, with practice over time, you will ... more

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Learning Modules. COVID-19 Vaccines in Pregnancy and Safe Breastfeeding

Pan American Health Organization (PAHO) (2023) C_WHO

This is an e-learning module with the objective of providing education for health professionals and pregnant women using published results and studies based on COVID-19 surveillance data, which have indicated an increased risk among pregnant women of presenting with severe forms of COVID-19 and, the... more

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The use of rectal artesunate as a pre-referral treatment for severe P. falciparum malaria

World Health Organization WHO (2023) C_WHO

Information note. In 2021, preliminary results of observational studies from the Community Access to Rectal Artesunate for Malaria (CARAMAL) project did not confirm the mortality impact observed in the controlled trial in 2009. Consequently, in January 2022, WHO released an information note on recta... more

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Guidance for mental health and psychosocial support for COVID-19
recommended

Africa CDC Centers for Disease Control and Prevention (2020) CC

This document provides guidance to African Union Member States on key mental health and psychosocial support (MHPSS) considerations in relation to the coronavirus disease 2019 (COVID-19) pandemic. It contains useful guidance on MHPSS for the community, healthcare workers, caregivers of vulnerable po... more

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How school systems can improve health and well-being: topic briefs: nutrition

World Health Organisation (WHO) (2023) C_WHO

This topic brief highlights how nutrition and healthy diets support the achievement of education and learning objectives, and explains how intervention benefits can be amplified with a whole-school and systems approach. The recommended actions are informed by the Global Standards for health-promotin... more

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Protecting people and animals from disease threats

Food and Agriculture Organization (FAO) (2018) C1

The Global Health Security Agenda programme develops national capacity to prevent zoonotic and non-zoonotic diseases while quickly and effectively detecting and controlling diseases when they do emerge. The Emerging Pandemic Threats programme improves national capacity to pre-empt the emergence and ... more

Antimicrobial Stewardship Program Guideline (India) recommended

Interim Guidance on the Use of Rapid Antigen tests for COVID-19 Response recommended

Shelter Safety Handbook recommended

Guidance for mental health and psychosocial support for COVID-19 recommended

Antimicrobial Stewardship Program Guideline (India)
recommended

Interim Guidance on the Use of Rapid Antigen tests for COVID-19 Response
recommended

Shelter Safety Handbook
recommended

Guidance for mental health and psychosocial support for COVID-19
recommended