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WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines.
Updated risk rates for hospital admission in patients with non-severe COVID-19
The guidance includes updated risk rates for
...
hospital admission in patients with non-severe COVID-19.
The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients.
This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines:
**High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%.
**Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%.
Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk.
Review of COVID-19 treatments for people with non-severe COVID-19
WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022.
If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead.
WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission.
For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol.
WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials.
The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials.
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With the advent and ongoing development of novel antiretroviral agents, people living with HIV (PLWHIV) are living longer and experiencing the effects of HIV infection on aging. The success of antir
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etroviral therapy (ART) has transformed HIV from a fatal disease into a manageable chronic condition, with PLWHIV on effective ART having life expectancies approaching those of the general population. As a result, a growing proportion of PLWHIV are 50 and older. The interplay between chronic HIV infection, the adverse effects of ART, and the natural aging process gives rise to unique challenges. These include an increased risk for conditions such as cardiovascular disease, metabolic syndrome, renal dysfunction, neurocognitive disorders, immunosenescence, and more
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Fact sheets: Best practics for a climate smart agriculture
Cerri, C.E.P.; et al.
Living Soil of the Americas; Inter-American Institute for Cooperation on Agriculture (IICA)
(2021)
CC
The Americas play a critical role in maintaining global food security while
helping to maintain the maximum levels of greenhouse gas concentrations
established by global climate conferences. This document prepared by the
Living Soils of the Ameri
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cas initiative presents technologies developed
and implemented in the region that can help in this huge global challenge
that is the preservation of food production and create favorable conditions
for the adaptation and mitigation of climate change through the adoption
of best agricultural practices
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Social inequalities are perpetuating unhealthy living and working conditions and behaviours. These causes are commonly called ‘the social determinants of health’. Achieving greater equity in hea
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lth will demand that the health sector assumes a greater leadership role in addressing social inequalities. This requires equipping health and care workers to better understand how the social determinants of health impact patients and communities. Education of the health workforce is thus a key step to advancing action. Integration of the social determinants of health into education and training will prepare the workforce to adjust clinical practice, define appropriate public health programmes and leverage cross-sector policies and mechanisms.
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Our World in Data: Natural Catastrophes
University of Oxford
(2018)
CC
Our World in Data is an online publication that shows how living conditions are changing. The aim is to give a global overview and to show changes over the very long run, so that we can see where we
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are coming from and where we are today. We cover a wide range of topics across many academic disciplines: Trends in health, food provision, the growth and distribution of incomes, violence, rights, wars, culture, energy use, education, and environmental changes are empirically analyzed and visualized in this web publication. For each topic the quality of the data is discussed and, by pointing the visitor to the sources, this website is also a database of databases. Covering all of these aspects in one resource makes it possible to understand how the observed long-run trends are interlinked.
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Over half a billion children are living in areas with extremely high levels of floods and nearly 160 million children live in areas of high or extremely high droughts. The World Health Organisation (WHO) estimates that 26% of the annual 6.6 million
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deaths of children under five are linked to environment-related causes and conditions. Children are also disproportionately affected by pollution, not only in terms of death rates, but also in terms of cognitive and physical development. This report illustrates that environmental causes also have an impact on whether children are pushed to work and on the kind of work they engage in, the conditions of work, exposure to dangerous toxicants and the risk of exploitation. However, the report raises more questions than it answers as it is one of the first reports addressing the question, how environmental degradation and climate change affect the vulnerability of children towards exploitation.
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Ministerial Instruction Number 20/40 of 10/09/2009 determining conditions and modalities for therapeutic care for people living with HIV and AIDS.
The magnitude and complexity of these mental health conditions caused by prolonged and extensive trauma requires a diagnosis fitting the unique context of the Syrian conflict. Over half a million people have been killed since the beginning of the co
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nflict in 2011, and more than 6.4 million are internally displaced with over 5 million living as refugees. SAMS documents the multi-dimensional nature of mental health disorders afflicting Syrians, including accounts of refugee experiences from Eastern Ghouta, Idlib, and beyond. This qualitative report seeks to raise awareness about increasing mental health needs, while sharing personal stories of those who have been affected by the trauma of the conflict.
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Over 2 million children worldwide are living with HIV infection and 95% reside in sub-Saharan Africa with the majority infected through mother-to-child transmission. Infected children have a high mortality with 50% dying by 2 years of age. Their cli
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nical presentation includes common childhood infections, opportunistic infections and conditions associated with HIV/AIDS immune suppression.
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Prioritise education in conflict-affected areas:
Across the world 28 million1 primary school-age children living in conflict-affected countries are
out-of-school, and they form half of the world’s total out-of-school population. During conflict,
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infrastructure assets such as schools are damaged or completely destroyed during fighting. Children
may choose to stay away from school due to their and their family’s safety fears in the midst of
conflict, or the need to supplement their family’s income amidst conflict-related financial loss.
Children who are internally displaced by conflict face a particularly challenging task accessing
education due to the specific conditions created by their displacement, such as loss of livelihoods
making school fees hard to find, and discrimination from host communities. Children caught in
conflict are being deprived of their right to education2 and denied the opportunity to benefit from the
protective and life-sustaining mechanisms of education.
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Preliminary overview of refugees and migrants self-reported impact of COVID-19
The study surveyed over 30,000 refugees and migrants living in 170 countries. Many of the respondents had fled war or dire economic
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conditions in their home country only to be faced with the additional challenges posed by COVID-19. Travel restrictions including border closures, suspension of resettlement travel, and last-minute deportation left many stranded or forced to stay in cramped, makeshift shelters or detention centers. Amid these uncertain, precarious conditions, many migrants described either a lack of access to health services or a fear of seeking them out — even if they were experiencing COVID-19 symptoms.
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The Barefoot Guide 5: Mission Inclusion - Stories and practices of building a world where all belong
From 2011 until 2016, a multi-actor programme was run in five countries to improve the life chances and living conditions of people experiencing exclusion and marginalisation of various kinds. This
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programme worked with local leaders, organisations and movements as well as various institutions and authorities
focusing on older people, those with mental health issues, people with disabilities, ethnic minorities, people displaced by war and youth at risk. Many initiatives were developed that had lasting effects on the ways in which these groups valued themselves and in which they are valued by society.
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In 2015, the National Institute of Statistics of Rwanda published the Rwanda Poverty Profile Report 2013/2014,which provided a detailed portrait of the extent and nature of poverty in the country, based on information collected by an integrated household l
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iving conditions survey (EICV4) undertaken between October 2013 and September 2014.
This report complements the study by looking at the trends in poverty between 2010/11 and 2013/14.It is essential to examine changes in poverty over time, because one of the most important goals of economic Sustainable Development Goals is to eliminate severe poverty by 2030.
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Around the world, millions of refugees and migrants in vulnerable situations, such as low-skilled migrant workers, face poorer health outcomes than their host communities, especially where living and working
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conditions are sub-standard, according to the first WHO World report on the health of refugees and migrants. This has dire consequences for the probability that the world will not achieve the health-related Sustainable Development Goals for these populations.
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The Life Skills through Drama curriculum aims at promoting the protection of Syrian and Lebanese adolescent girls from Gender Based Violence and enhancing their psychosocial wellbeing. This curriculum addresses the basic life skills that adolescent girls l
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iving in difficult conditions in any similar cultural context could need. The curriculum relies on active learning through experience, practice, reflection and discussion. And it has been designed based on drama techniques. Varied creative drama techniques were used to serve the objectives including techniques from Theater of the Oppressed
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People in prisons and other places of detention live in a closed environment and in close proximity with one another – conditions that facilitate transmission of diseases. They also have a greater underlying burden of disease and worse health
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conditions than the general population, and frequently face greater exposure to risks such as smoking, poor hygiene and weak immune defence due to stress, poor nutrition or existing diseases. All these factors make people living in prison more susceptible to infections.
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The WHO guidelines on mental health at work provide evidence-based recommendations to promote mental health, prevent mental health conditions, and enable people living with mental health
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conditions to participate and thrive in work. The recommendations cover organizational interventions, manager training and worker training, individual interventions, return to work, and gaining employment. The guidelines on mental health at work aim to improve the implementation of evidence-based interventions for mental health at work.
Executive summary available in Arabic, Chinese, English, French, Russian, Spanish
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The Monitoring Report, which covers the first two months of the response from 25 August to 31 October, highlights the work of the Government of Bangladesh, in cooperation with humanitarian partners who are working to provide relief services for the refugee population and Bangladeshi host communities
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. Of the 1.2 million people in need, around half have been reached with assistance. The Report also explains the challenges and gaps that remain. The risk of disease outbreak is high, and the impact of a cyclone or heavy rain would be massive. There is not enough land to provide adequate living conditions for the more than 830,000 refugees that now crowd Cox’s Bazar.
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For over a decade, Senegalese and international journalists, human rights advocates, and child protection experts have documented and denounced the ongoing exploitation, abuse and neglect of children living in many of Senegal’s traditional Quranic
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schools, or daaras. Thousands of these children, known as talibés, continue to live in conditions of extreme squalor, deprived of adequate food and medical care.
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