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Q7: In individuals with bipolar mania, are a) antipsychotics, b) mood stabilizers (lithium carbonate, valproate, and carbamazepine) effective and safe
Q9: Antidepressant medicines in individuals with a depressive episode in bipolar disorder1Q9: In individuals presenting with a depressive episode in bipolar disorder, are antidepressant medicines effective and safe?
In the Region of the Americas, between epidemiological week (EW) 1 and EW 52 of 2018, a total of 560,586 cases of dengue were reported (incidence rate of 57.3 cases per 100,000 population), including 336 deaths. Of the total cases, 209,192 (37.3%) were laboratoryconfirmed and 3,535 (0.63%) were clas ... more
The humanitarian crisis in Yemen remains the worst in the world. Nearly four years of conflict and severe economic decline are driving the country to the brink of famine and exacerbating needs in all sectors. An estimated 80 per cent of the population – 24 million people – require some form of h ... more
Communities can play a critical role in suicide prevention. Facilitating community engagement in suicide prevention is an important task. The toolkit is a step-by-step guide for communities to engage in suicide prevention activities and have ownership of the process and keep efforts sustained. It is ... more
The WHO Global Burden of Disease (GBD) study measures the burden of disease using the disability-adjusted life year metric (DALY). The DALY metric was developed to assess the burden of disease consistently across diseases, risk factors and regions. A consistent and comparative description of the ... more
Report of the Global Thematic Consultation on Population Dynamics
Limited research has examined factors associated with psychological distress following natural disasters among non-Western child populations. Conditions associated with trauma-related symptoms following the 2004 tsunami in a sample of 265 Sri Lankan child survivors (53.6% female, aged 3 to 17) were ... more

Role of a medical review

World Health Organization (2012) C_WHO
Q8: For people with dementia, what is the role of a medical review (including comorbid physical and mental conditions and medication use)?

Cognitive and psychosocial interventions

World Health Organization (2012) C_WHO
Q5: For people with dementia, which cognitive/psychosocial interventions (such as cognitive stimulation, cognitive rehabilitation, reality orientation, reminiscence therapy) when compared to placebo/comparator produce benefits/harm in the specified outcomes?
Areas for action include: increasing prioritisation and awareness of dementia; reducing the risk of dementia; diagnosis, treatment and care; support for dementia carers; strengthening information systems for dementia; and research and innovation.
Scoping Question: For adults and children living with HIV, which antiepileptic medications (such as phenobarbital, phenytoin, carbamazepine or valproic acid) produce benefits and/or harms when compared to a placebo or controls?

Antiepileptic drug treatment after first unprovoked seizure

World Health Organization (2012) C_WHO
Q8. Should Anti-Epileptic Drug (AED) treatment be started after first unprovoked seizure in non-specialist health settings?
SCOPING QUESTION: In adults with acute convulsive seizures, where intravenous access is available, which first-line anti- epileptic medication should be used to abort seizures when compared to comparator?
[Updated 2015] Scoping Question: In adults with acute convulsive seizures in first-level care or in the community (when no IV access is available), which antiepileptic medications produce benefits and/or harm when compared to comparator?
SCOPING QUESTION: In adults with established status epilepticus (i.e., seizures persisting after the first-line treatment with benzodiazepines [or benzodiazepines-resistant status epilepticus]), which anti-epileptic medications are associated with cessation of seizures and reduced adverse effects)? ... more

Management of epilepsy in women of child bearing age

World Health Organization (2012) C_WHO
Q11: 11a). In women with epilepsy, should antiepileptic therapy be prescribed as monotherapy or polytherapy to decrease the risk of fetal malformations? 11b). Does the use of folic acid preconceptually decrease the risk of foetal malformations in women with epilepsy? 11c). Do phenytoin, phenobarbi ... more
This compendium collates current tools and resources on quality improvement developed by the WHO Service Delivery and Safety Department and provides examples of how the tools and resources have been applied in country settings. The target audience for this document are ministries of health, facility ... more
This Plan envisions a future with the elimination of cervical cancer as a public health problem as a result of universal access to sexual health and STI prevention services, HPV vaccines, effective screening and precancer treatment services, treatment of invasive cervical cancer, and palliative care ... more

лечение поведенческих и психотических симптомов деменции во внебольничных условиях

Колыхалов И.В., Гаврилова С.И. Федеральное государственное бюджетное учреждение «Научный центр психического здоровья» Российской академии медицинских наук (2012) C2
В методических рекомендациях представлены современные подходы к терапии поведенческих и психотических расстройств у пациентов с болезнью Альцгеймера. Ведение т ... more