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Guidelines on lenacapavir for HIV prevention and testing strategies for long-acting injectable pre-exposure prophylaxis. Web Annex G Abstract
Updated guidance on the integration of diabetes, hypertension and mental health services, and interventions to support adherence to antiretroviral therapy. The guideline offers practical implementation guidance for countries and key stakeholders as well as outlining key research gaps. As life expec ... more
This brief report summarizes recent information on HIV drug resistance (HIVDR) in the era of integrase-strand transfer inhibitors (INSTI) for HIV prevention and treatment.
Topics in Antiviral Medicine, March 4, 2025
CDC leads an international surveillance effort to estimate the occurrence of HIV drug resistance among people with HIV who are taking dolutegravir (DTG)-based treatments. This surveillance effort utilizes Cyclical Acquired HIV Drug Resistance Surveillance (CADRE), a laboratory-based HIV drug resista ... more
During ARV drug pressure the HIV-1 RT is able to develop resistance to these drugs by generating mutations

HIV Drug Resistance

Gingo, D. Ministry of Health, Uganda (2022) C1
ATIC Newsletter, Vol 15, Issue 1, February 2022.
These guidelines, produced in 2022 by the Uganda Ministry of Health, provide guidance on the diagnosis of HIV, the care of people living with HIV, and the use of antiretroviral drugs for treating and preventing HIV infection, including injectable cabotegravir and the dapivirine vaginal ring.
This document provides an overview of the updated World Health Organization recommendations for HIV clinical management, which focus on optimizing antiretroviral therapy, preventing vertical transmission, and enhancing tuberculosis prevention among individuals with HIV. These updates are intended to ... more
what lessons can we take from the last few decades of health behaviour change efforts as we enter the era of HIV prevention pills, rings and injections?
Questions and answers. A key priority is preventing the interruption of current HIV treatment and prevention medicines. This Q&A outlines advice when this is not possible. Available in Arabic, Chinese, English, French, Portuguese, Russian and Spanish
These 2025 guidelines respond to the need for better approaches to identify advanced HIV disease, improve the poor outcomes of people living with HIV being discharged from hospital and provide updated guidance for treatment for Kaposi’s sarcoma through evidence-informed recommendations. The public ... more
About six in ten adolescents 10-19 years of age living with HIV are on antiretroviral medications
Slightly more than half of children under 15 years of age living with HIV are on antiretroviral medications
The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations. The guidelines were updated to comply with Executive Orders. You can download the full guidelines, charts and recommendations
JAMA. 2025;333(7):609–628. doi:10.1001/jama.2024.24543
Nature communications, 16, 906 (2025). https://doi.org/10.1038/s41467-025-56116-1
Recent suspensions and reductions in official development assistance (ODA) have posed significant challenges to HIV programme continuity in several countries. These funding disruptions have impacted people living with HIV and other vulnerable populations who rely on these essential services, like a ... more
Dosing of LPV/r by formulation & dose modification (RTV super-boosting/double-dose LPV/r) for children receiving rifampicin-containing TB treatment. Chart
Annexure 6 National Guidelines South Africa 2023