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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Republic of South Africa: Antimicrobial Resistance National Strategy Framework 2018 – 2024

Departments of Health and Agriculture, Forestry and Fisheries for the Republic of South Africa (2014) C_WHO

The National Department of Health and Department of Agriculture, Forestry and Fisheries have collectively engaged to determine the key interventions that will form the basis for this strategy taking into account the recommendations from the WHO and OIE. The development and implementation of a Natio... more

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Chagas Disease: Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV

Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV Clinical Info HIV (2023) CC

Epidemiology Chagas disease (American trypanosomiasis) is caused by the protozoan parasite Trypanosoma cruzi, and transmitted to humans by infected triatomine bugs, and less commonly by transfusion, organ transplant, from mother to infant, and in rare instances, by ingestion of contaminated food or... more

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Myanmar’s National Adaptation Programme of Action (NAPA) to Climate Change

The Republic of the Union of Myanmar, Ministry of Environmental Conservation and Forestry, National Environmental Conservation Committee (2012) C1

Sectors in which Priority Adaptation Projects should be implemented first include:
- 1) Agriculture, Early Warning Systems and Forest (First Priority Level Sectors). This is followed by:
- 2) Public Health and Water Resources (Second Priority Level Sectors);
- 3) Coastal Zone (Thir... more

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Abuja Declaration on HIV/AIDS, Tuberculosis, and Other Infectious Diseases

African Union (AU) African Union (AU) (2001) CC

The Abuja declaration identifies that the prevention and control of HIV/AIDS, tuberculosis and related infectious diseases must come with additional financial resources. Therefore, African governments agreed on setting the target of allocating at least 15 per cent of each country’s annual budget ... more

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Let's talk TB: a free, online book for primary care providers

Madhukar Pai GP clinics (2018) CC

The third edition, released in 2018, has grown to include a total of 18 chapters, contributed by 20 experts and authors from many countries. The goal remains the same: to educate primary care providers on the best practices in TB diagnosis, treatment and follow-up. All articles are richly illustrate... more

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Financing Global Health 2016: Development Assistance, Public and Private Health Spending for the Pursuit of Universal Health Coverage

Institute for Health Metrics and Evaluation (IHME) Institute for Health Metrics and Evaluation (IHME) (2017) C2

Financing Global Health 2016: Development Assistance, Public and Private Health Spending for the Pursuit of Universal Health Coverage presents a complete analysis of the resources available for health in 184 countries, with a particular focus on development assistance for health (DAH). DAH was estim... more

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Developing, Implementing, and Monitoring the Use of Standard Treatment Guidelines: A SIAPS How-To Manual

Systems for Improved Access to Pharmaceuticals and Services (SIAPS) MSH, USAID (2015) CC

STGs are designed to assist health care professionals in making decisions about appropriate, effective patient care. However, health managers often have trouble setting and meeting the high standards required of modern, developed health care systems. With stakeholders expressing concern over issues ... more

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COVID-19: Strategic preparedness and response plan for WHO African Region 1 February 2021-31 January 2022 (Update of 16 April 2021)

World Health Organization WHO, Regional Office of Africa; UNICEF (2021) C_WHO

The 2021 COVID-19 Strategic Preparedness and Response Plan (SPRP) for AFR serves as a regional guide for a holistic public health response to COVID‑19 at regional, national and sub-national levels. The 2021 SPRP: 1. Builds upon the lessons learnt from the implementation of the 2020 SPRP and outl... more

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WHO Emergency Appeal: Health Crisis in Flood-Affected Pakistan
recommended

World Health Organization WHO (2022) C_WHO

Pakistan is on the verge of a public health disaster as a result of the massive monsoon rainfalls and unprecedented levels of flooding that are affecting 33 million people across the country. The risk of disease outbreaks is extremely high and malnutrition rates are rising. WHO requires US$ 81.5 m... more

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Nutrition Cluster Handbook
recommended

Josephine Ippe, Diane Holland, Leah Richardson, et al. The Global Nutrition Cluster, UNICEF (2013) C1

The purpose of the handbook is to provide those involved in nutrition coordination with relevant tools, guidance, information and resources to support their roles in facilitating predictable, coordinated and effective preparation for, and responses to, nutrition needs in humanitarian emergencies. Ra... more

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Humanitarian assistance and protection for people on the move

The International Federation of Red Cross and Red Crescent Societies IFRC (2021) C1

People on the move – migrants, refugees, asylum seekers and other displaced populations – face extraordinary risks to their lives, safety, dignity, human rights and well-being. In part this is connected to the core reasons that lead to migration and displacement, ranging from violence, persec... more

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Prioritization of Zoonotic Diseases in Kenya, 2015

Munyua P., A.Bitek, E.Osoro; et al (2016) CC

PlosOne https://doi.org/10.1371/journal.pone.0161576; Zoonotic diseases have varying public health burden and socio-economic impact across time and geographical settings making their prioritization for prevention and control important at the national level. We conducted systematic prioritization of ... more

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International Pharmaceutical Federation (FIP) - A handbook for pharmacists

Nunes da Cunha I., Autry E. et al International Pharmaceutical Federation (FIP) (2022) CC2

The document "Chronic Respiratory Diseases: A Handbook for Pharmacists" outlines the significant role pharmacists play in managing asthma and COPD, emphasizing patient education, disease prevention, medication management, and promoting healthy lifestyles. It highlights the importance of pharmacists ... more

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Primary health care and HIV: convergent actions - Policy considerations for decision-makers

World Health Organization WHO (2023) C_WHO

The 2030 health-related Sustainable Development Goals call on countries to end AIDS as a public health threat and also to achieve universal health coverage. The World Health Organization (WHO) promotes primary health care (PHC) as the key mechanism for achieving universal health coverage, and the PH... more

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Fourth National Climate Assessment (NCA4)

U.S. Global Change Research Program (2018) C2

The Fourth National Climate Assessment (NCA4) fulfills that mandate in two volumes. This report, Volume II, draws on the foundational science described in Volume I, the Climate Science Special Report (CSSR).2 Volume II focuses on the human welfare, societal, and environmental elements of climate cha... more

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View PDF (2009)

Preventing suicide: A global imperative

World Health Organization (WHO) (2014) C_WHO

The report provides a global knowledge base on suicide and suicide attempts as well as actionable steps for countries based on their current resources and context to move forward in suicide prevention.

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Getting the Message Across

UNESCO's International Programme for the Development of Communication (IPDC) (2019) C1

Reporting on Climate Change and Sustainable Development in Asia and the Pacific: A Handbook for Journalists. UNESCO Series on Journalism education. It explores the essential aspects of climate change, including its injustices to vulnerable communities, especially women and girls and least develope... more

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WHO Pharmacovigilance indicators: a practical manual for the assessment of pharmacovigilance systems

World Health Organization WHO (2015) C_WHO

This manual provides a practical method for determining the pharmacovigilance indices. It is designed to be simple and can be understood by any worker in pharmacovigilance without formal training in monitoring and evaluation. Pharmacovigilance as a medical discipline is crucial in preventing medicin... more

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Medical Ethics and Bedside Rationing in Low‐Income Countries: Challenges and Opportunities

Kapiriri, L. ResearchGate (2017) CC

Bioethics - Medical, Ethical and Legal Perspectives There’s evidence that implementing the four medical ethics principles may be challenging especially in low income country contexts with extreme resource scarcity and limited capacity to facilitate deliberations on the different ethical dilemmas.... more

WHO Emergency Appeal: Health Crisis in Flood-Affected Pakistan recommended

Nutrition Cluster Handbook recommended

WHO Emergency Appeal: Health Crisis in Flood-Affected Pakistan
recommended

Nutrition Cluster Handbook
recommended