Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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2023 is seeing intense heatwaves. According to a July 2023 briefing by the World Meteorological Association temperatures will frequently reach above 35–40°C in many places across the Mediterranean region, with temperatures in the Middle East and southeastern Türkiye reaching up to 45°C and, in ...North Africa, 44–49°C. April–May 2023 also saw temperature records broken across many parts of Asia, including Thailand, Laos and Myanmar.
The IPCC predicts that 420 million people will be exposed to extreme heat and heatwaves in the near future. Hundreds of thousands of people die from preventable heat-related causes each year, while temperature extremes and wildfires cause devastation to lives and livelihoods. According to the WMO, ‘heatwaves are amongst the deadliest natural hazards [and] heat is a rapidly growing health risk’.
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Handout presentations in PDF for illustrating lectures
Accessed May 2014
To improve connections between local media and Ebola responders Internews has created an updated and comprehensive list of all media outlets working in the country, including their contact information, their social media presence, their website and their reach.
Encuesta Nacional de Condiciones de Vida 2016 (ENCOVI 2016)
A short movie about the history and the current status of antibiotics from the four week online course: Antibiotic Resistance: the silent tsunami, produced by ReAct and Uppsala University, Sweden.
EN BARRIOS POPULARES DE TEGUCIGALPA
21.12.2020
Available in English, Spanish, Italian and Portuguese
Six months after the earthquake, World Vision's efforts have made it possible to provide emergency assistance to selected beneficiaries among the most vulnerable through the distribution of food and hygiene kits and to address the psychosocial needs of children, adolescents, and young people deprive...d of classrooms. During this recovery phase of the response by World Vision teams have been focusing on rebuilding and rehabilitating school infrastructure in order to facilitate the return to school in safer conditions given the almost permanent seismic risks. Six months later, the security situation continues to deteriorate with an increase in kidnappings and nationwide strikes to protest against the rising insecurity.
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La Estrategia regional se dirige a los principales países de acogida de la población refugiada y migrante proveniente de Venezuela; en particular, a las instituciones gubernamentales que tienen algún grado de competencia en la integración socioeconómica de esta población y a las organizaciones... de empleadores y trabajadores, con el ánimo de promover el diálogo social alrededor de este ámbito.
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Senegal is on course to meet the global target for under-five overweight, but is off course to meet the targets for all other indicators analysed with adequate data.
The International Water Management Institute (IWMI) was commissioned to undertake a rapid review of access to and management of water resources in the Dry Zone, to assist LIFT and other potential donors and investors to identify the key issues and the priority actions for water management.
The ...study had three main components:
• A water resources assessment (surface and ground water) of availability, current use, and patterns, trends and variability at different spatial and temporal scales.
• Community survey to evaluate issues of water availability, access and management for different livelihood types in 24 local communities, including evaluation of institutional arrangements in relation to farming strategies and water management practices
• Review and analysis of existing program investments in water in the Dry Zone
Findings from the study are available in three reports (for details, see last page).
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Antimicrobial resistance(AMR) poses a serious threat to human, animal and environmental health. Implementing ethical practice guidelines on how to use antimicrobials effectively and responsibly within the pig industry will contribute in reducing and preventing antimicro...bial resistance within the pig industry of South Africa. Members of Pig Vet Society (PVS) SA hereby commit themselvesto put these guidelines into good use in order to preserve the future and effectiveness of antimicrobials. PVS aims to be the leader in prevention of antimicrobial resistance and to encourage the pig industry to work together in achieving this.
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