WHO recommends that pre-exposure prophylaxis (PrEP) be offered as an additional prevention choice for HIV-negative individuals at substantial risk of HIV infection as part of combination prevention approaches.
HIV drug resistance has been rarely reported among PrEP users who tested HIV positive i...n randomized controlled trials or open-label studies. However, PrEP-selected HIV drug resistance could potentially negatively impact the effectiveness of treatment options among PrEP users who acquire HIV, since there is a potential for overlapping resistance profiles between antiretroviral drugs used for both PrEP and first-line antiretroviral therapy.
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The technical note from the Global Task Force on Cholera Control (GTFCC) examines the risks and benefits of vaccinating pregnant women with WHO-prequalified oral cholera vaccines (OCVs) during mass vaccination campaigns. It highlights that three WHO-approved vaccines (Dukoral®, Shanchol™, and Euv...ichol®) offer sustained protection and a strong safety profile.
While these vaccines are not explicitly contraindicated for pregnant women, there is limited clinical data on their use during pregnancy. However, studies indicate that pregnant women with cholera face higher risks of fetal loss, stillbirth, and complications, especially if they experience severe dehydration. Some evidence suggests that vaccination can reduce cholera incidence in pregnant women and indirectly protect infants.
Although no controlled trials have focused on pregnant women, retrospective studies in Guinea and Zanzibar showed no significant increase in adverse pregnancy outcomes after OCV administration. The GTFCC concludes that the benefits of vaccination outweigh the risks, particularly in high-risk areas, and recommends including pregnant women in cholera vaccination campaigns while continuing to monitor safety data.
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Background
The core clinical symptoms of addiction include an enhanced incentive for drug taking (craving), impaired self-control (impulsivity and compulsivity), emotional dysregulation (negative mood) and increased stress reactivity. Symptoms related to impaired self-control involve reduced activi...ty in anterior cingulate cortex (ACC), adjacent prefrontal cortex (mPFC) and other brain areas. Behavioral training such as mindfulness meditation can increase the function of control networks including those leading to improved emotion regulation and thus may be a promising approach for the treatment of addiction.
Methods
In a series of randomized controlled trials (RCTs), we tested whether increased ACC/mPFC activity is related to better self-control abilities in executive functions, emotion regulation and stress response in healthy and addicted populations. After a brief mindfulness training (Integrative Body-Mind Training, IBMT), we used the Positive and Negative Affect Schedule (PANAS) and Profile of Mood States (POMS) to measure emotion regulation, salivary cortisol for the stress response and fMRI for brain functional and DTI structural changes. Relaxation training was used to serve as an active control.
Results
In both smokers and nonsmokers, improved self-control abilities in emotion regulation and stress reduction were found after training and these changes were related to increased ACC/mPFC activity following training. Compared with nonsmokers, smokers showed reduced ACC/mPFC activity in the self-control network before training, and these deficits were ameliorated after training.
Conclusions
These results indicate that promoting emotion regulation and improving ACC/mPFC brain activity can help for addiction prevention and treatment.
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Long Acting Muscarinic Antagonists (LAMA) such as tiotropium and glycopyrronium are used in the management of COPD1. They have been shown to improve lung function, quality of life and exercise tolerance. They have also been associated with reduced COPD-related exacerbations, associated hospitalisati...ons and duration of hospital stay. Both the South African Thoracic Society (SATS) and Global Initiative for Chronic Obstructive Lung Disease (GOLD), guidelines recommend the use of long acting anticholinergic drugs (or long acting beta agonists) in moderate to very severe disease as defined by lung function (FEV1). The most up to date guideline, utilizing the GRADE methodology (European Respiratory Society guidelines of 2017), confirms their superiority over long acting β agonists (LABA) as monotherapy for COPD in that LAMA's have demonstrated greater efficacy in terms of exacerbation reduction, with similar safety profile.2 These recommnedations are supported by published peer-reviewed
evidence including individual papers and Cochrane reviews.
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Training Manual
Building on earlier EngenderHealth work in counseling, Counseling for Effective Use of Family Planning responds to an identified gap in existing materials and fills the needs expressed by those in the field. The intended audiences for this curriculum are health care providers, their... supervisors, and the managers of the programs in which they work. The counseling skills addressed here are expected to be relevant to the provision of both preventive and curative health services through the workshop participants’ national health systems. Finally, the curriculum’s participatory approach to defining terms and to generating profiles of potential clients is designed to assist trainees in addressing the realities and exploring the reproductive health priorities of their communities in a culturally appropriate manner.
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Le présent plan prend la suite de deux plans nationaux pour préserver l’efficacité des antibiotiques (2001-2005 et 2007-2010), qui visaient à maîtriser et rationaliser la prescription des antibiotiques. Ce troisième plan a pour titre « plan national 2011-2016 d’alerte sur les antibiotique...s ». Derrière ce titre se profile une menace de santé publique majeure : un nombre croissant de situations d’impasse thérapeutique contre des infections bactériennes, du fait du développement des résistances aux antibiotiques. Cette menace appelle une mobilisation déterminée et durable de l’ensemble des acteurs impliqués dans le cycle de vie des antibiotiques, afin de concilier des objectifs individuels (qualité de la prise en charge des patients) et collectifs (préservation d’une ressource rare, précieuse et difficile à renouveler).
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The Bolivarian Republic of Venezuela has been facing a prolonged socio-political and economic situation that has profoundly and negatively impacted social and health indicators. The COVID-19 pandemic further aggravated the humanitarian context in the
country, which stretched the limits of an alread...y weakened national health system. Violence and social conflicts, hyperinflation, constant political tensions, the persistence of migratory movements, and intensification of climate threats and natural hazards
have worsened the living conditions and health status of populations in vulnerable situations, including women, children, and indigenous people. A large influx of returnees back to Venezuela (Bolivarian Republic of) marked the first
two years of the pandemic. However, the country’s continued deteriorating political, socio-economic, and human rights situation resulted in renewed increased migration of Venezuelans in 2022. The profile of Venezuelan migrants has progressively changed
over the years, from single men in search of better economic opportunities to families with women and children in situations of extreme vulnerability. The increasingly irregular and unsafe journeys of those migrants are constantly putting their lives at high risk
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Health facilities in the Region of the Americas frequently suffer the effects of health emergencies and disasters, which jeopardize their ability to provide services to the population. The STAR-H methodology helps staff responsible for health emergency and disaster risk management to identify and as...sess risks as part of strategic planning to improve facility preparedness. It is intended to help them develop, with a multi-hazard approach, a response framework with operating procedures to deal with hazards of any type, scale, or frequency; determine roles and responsibilities; facilitate the effective use of resources; undertake strategic planning exercises, and improve the preparedness of facilities to effectively respond to and recover from impacts. This methodology is designed for use in health facilities of any size and capacity, and makes it possible to generate historical reports and national or subnational risk profiles. This information can be used to develop an effective health emergency and disaster risk management program.
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West: Drada & Nagar Haveli, Daman & Diu, Goa, Gujarat, Maharashtra
South: Andhra Pradesh & Telangana, Karnataka, Kerala, Puducherry, Tamil Nadu
This technical document consists of epidemiological profiles (fact-sheets) for States and districts based on information available from multiple d...ata sources including the HIV Sentinel Surveillance (HSS) and the Integrated Biological and Behavioural Surveillance (IBBS). Given the need for focussed prevention efforts in low/high prevalence and vulnerable States/districts, the information presented will be useful for policy makers, program planners at national/State/ district level, researchers, and academicians in identification of areas for priority attention and also to derive meaningful conclusions for programme planning, implementation, monitoring and scale-up. This document will be a quick reference for the HIV/AIDS situation in a State/district, risk and safe behaviour of the high risk groups, their level of knowledge about STIs and HIV/AIDS, experience of violence, HIV testing and ART awareness and exposure to HIV/AIDS prevention.
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Development of cardiovascular disease (CVD) is influenced by risk factors such as:
tobacco use, an unhealthy diet, physical inactivity, obesity (which can result from
a combination of unhealthy diet, physical inactivity, and other factors), elevated
blood pressure (hypertension), abnormal blood l...ipids (dyslipidaemia) and elevated blood glucose (diabetes mellitus). Continuing exposure to these risk factors leads
to further progression of atherosclerosis, resulting in clinical manifestations of these diseases, including angina pectoris, myocardial infarction, heart failure and stroke. Total CVD risk depends on the individual’s overall risk-factor profile.
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The document is part of the Financing Global Health 2023 series by the Institute for Health Metrics and Evaluation (IHME) and focuses specifically on malaria. It provides a concise overview of global and regional trends in malaria-related health spending, including development assistance, government... spending, and out-of-pocket costs. The profile highlights funding gaps, shifts in donor contributions, and the need for sustainable financing to support malaria control and elimination efforts in the post-pandemic era.
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The WHO Eastern Mediterranean Regional Office's webpage on cholera information resources provides a comprehensive collection of materials to support understanding and management of cholera outbreaks. It includes posters for public education, recent publications such as Global Defence Against the Inf...ectious Disease Threat (with a chapter on cholera), Cholera Outbreak: Assessing the Outbreak Response and Improving Preparedness, and First Steps for Managing an Outbreak of Acute Diarrhoea. Additionally, it features policy documents like the WHO statement on international travel and trade during cholera outbreaks and the World Health Assembly resolution WHA 64.15 on cholera control and prevention. The page also links to the Global Task Force on Cholera Control and provides cholera country profiles, offering valuable insights into global and regional efforts to combat cholera.
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This report provides an update on the key facets of HIV treatment access, including the latest HIV treatment guidelines from World Health Organization (WHO), an overview on pricing for first-line, second-line, and salvage regimens, and a summary of the opportunities for – and threats to – expand...ing access to affordable antiretroviral therapy (ART).
The report is supplemented by 11 drug profiles that contain more detailed information on pricing trends and patent barriers for key antiretroviral drugs and fixed-dose combinations. Also included is an annex of conditions that define eligibility for reduced prices from 15 pharmaceutical companies.
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The new WHODAS 2.0 supersedes WHODAS II and shows the following advantages:
- A generic assessment instrument for health and disability
- Used across all diseases, including mental, neurological and addictive disorders
- Short, simple and easy to administer (5 to 20 minutes)
- Applicable in both... clinical and general population settings
- A tool to produce standardized disability levels and profiles
- Applicable across cultures, in all adult populations
- Directly linked at the level of the concepts to the International
- Classification of Functioning, Disability and Health (ICF)
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Everyone, all over the world, deserves to live a long life in full health. In order to achieve this goal, we need a comprehensive picture of what disables and kills people across countries, time, age, and sex. The Global Burden of Disease (GBD) provides a tool to quantify health loss from hundreds o...f diseases, injuries, and risk factors, so that health systems can be improved and disparities can be eliminated.
You can have access to GBD Resources, Data Visualizations, Studies & Reports; Data, Country Profiles and the Lancet GBD Studies
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the one-stop shop online resource for cancer planners. Here you can find a library of resouces for develop a national cancre control plan, statistics, stay updated, technical assistance and you can discover on an interactive map cancer and NCD plans, as well as country profiles
The executive summary of the WHO Global oral health status report presents a snapshot of the most recent data on major oral diseases, risk factors, health system challenges and opportunities for reform. The report’s clear conclusion is that the status of global oral health is alarming and requires... urgent action. The report will serve as a reference for policy-makers and an orientation for a wide range of stakeholders across different sectors to guide advocacy towards better prioritization of oral health in global, regional and national contexts. In addition, the report provides, as a separate online resource, the first-ever country oral health profiles for all 194 WHO Member States, giving unique insights into key areas and markers of oral health that are relevant for decision-makers.
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This is the 19th annual Landmine Monitor report. It is the sister publication to the Cluster Munition Monitor report, first published in November 2010.
Landmine Monitor 2016 provides a global overview of the landmine situation. Chapters on developments in specific countries and other areas are ava...ilable in online Country Profiles at www.the-monitor.org/cp.
Landmine Monitor covers mine ban policy, use, production, trade, and stockpiling, and also includes information on contamination, clearance, casualties, victim assistance, and support for mine action. The report focuses on calendar year 2015, with information included up to November 2016 when possible.
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La hemorragia posparto (HPP) se define comúnmente como la pérdida de sangre
de 500 ml o más en el término de 24 horas después del parto. La HPP es la causa
principal de mortalidad materna en países de ingresos bajos y la causa primaria de
casi un cuarto de todas las defunciones maternas en ...todo el mundo. La mayoría de las
muertes provocadas por HPP ocurren durante las primeras 24 horas después del parto:
la mayoría de estas podrían evitarse a través del uso profiláctico de agentes uterotónicos
durante el alumbramiento y mediante un tratamiento oportuno y apropiado.
Mejorar la atención de la salud de las mujeres durante el parto para prevenir y tratar la HPP
representa un paso necesario para el cumplimiento de los Objetivos de Desarrollo del Milenio.
Por lo tanto, el objetivo primario de esta directriz es proporcionar los cimientos para el
desarrollo estratégico de políticas y programas necesarios para garantizar la implementación
sostenible de intervenciones eficaces para reducir la carga global que representa la HPP.
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L’enseignement des soins infirmiers se fait sous la tutelle du ministère de la Santé et de la Prévention médicale.Il est en pleine effervescence,mais seulement avec deux niveaux de formation.
- En premier lieu,il y a la formation initiale qu’une seule institution nationale a assurée de 195...2 à 1992.Avec la pénurie de la main-d’œuvre et la libéralisation de l’éducation,le Sénégal fait face depuis une quinzaine d’années à l’ouverture effrénée d’écoles privées dont la majorité dispose d’un agrément du ministère de la Santé.Le diplôme requis à l’entrée dans ces institutions de formation est le baccalauréat de l’enseignement général (13 ans de scolarité).La durée des études est de trois années sanctionnées par un diplôme d’État d’infirmier délivré par le ministère de la Santé et de la Prévention médicale,pour les diplômés des secteurs public et privé. - En deuxième lieu,il y a la formation continue spécialisée,dans les huit filières suivantes:enseignement et administration,anesthésie et réanimation,kinésithérapie,biologie,imagerie médicale,odontologie,ophtalmologie et néphrologie.Elle est offerte sur une période de deux ans,par l’École nationale de développement sanitaire et social (ENDSS).Le profil de sortie permet aux soignants d’exercer leur profession spécialisée avec le diplôme de technicien supérieur de santé.
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