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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

Global Burden of Disease 2021 Health Financing Collaborator Network The Lancet Glob Health (2023) C2

The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well ... more

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Generic protocol for a population-based, age- and gender- stratified sero-survey study for SARS-CoV-2

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1

The number of confirmed COVID-19 cases detected and reported in each country is influenced by many factors including limited access and/or utilization of healthcare and COVID-19 testing, limited surveillance, lack of knowledge amongst the population about when to seek testing, an asymptomatic pres... more

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Guidance on pooled testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1

The purpose of this document is to provide guidance on the use of pooled sample testing strategy in coronavirus disease (COVID-19) testing laboratories of the African Union Member States for scaling up SARS-CoV-2 nucleic acid testing capacity with the available resources. The current document descr... more

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Cutaneous Radiation Injury: A Brochure for Physicians

Centers for Disease Control and Prevention (CDC) (2018) C_CDC

Injury to the skin and underlying tissues from acute exposure to a large external dose of radiation is referred to as cutaneous radiation injury (CRI). Acute radiation syndrome (ARS) 1 will usually be accompanied by some skin damage; however, CRI can ... more

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Ebola emergency preparedness in EU Member States: Conclusions from peer-review visits to Belgium, Portugal and Romania

ECDC (European Centre for Disease Prevention and Control) (2015) CC2

This report presents the main characteristics of Ebola emergency preparedness in three EU Member States. Findings are organised in five sections: preparedness planning, organisational structures, recourses and capacities, intersectoral and cross-border collaboration, and country-specific findings

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Communication toolkit to promote prudent antibiotic use aimed at primary care prescribers

European Centers for Disease Control and Prevention ECDC (2009) C2

The toolkit offers advice on how national public health authorities could engage with primary care prescribers so as to promote appropriate and responsible use of antibiotics. The toolkit contains template materials and some suggested key messages for health professionals, idea... more

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Testing Guidance - Dengue Fever - CDC

Centers for Disease Control and Prevention CDC (2023) C2

Websites last accessed on 31.03.2023 Dengue testing guidance according to days of symptom onset.

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Dengue Clinical Case Management course (DCCM)

Centers for Disease Control and Prevention CDC (2020) C_CDC

PROGRAM DESCRIPTION: Course is designed to increase knowledge and develop competency in the management of patients suspected of infection with dengue virus.

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Share facts about COVID-19

Centers for Disease Control and Prevention CDC CDC (2020) C1

Know the facts about coronavirus disease 2019 (COVID-19) and help stop the spread of rumors.

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Factsheet for experts - Antimicrobial resistance

European Centers for Disease Control and Prevention ECDC (2019) CC

Nosocomial infections and antimicrobial resistance are two special health issues listed in Annex 1 of Commission Decision 2000/96/EC of 22 December 1999 on the communicable diseases to be progressively covered by the Community network under Decision No 2119/98/EC of the European Parliament and of th... more

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Guidance for Awake Prone Ventilation in the non-intubated Conscious Patient
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2020) CC

It is intended for use among clinicians taking care of moderate to severe COVID-19 cases. The COVID-19 outbreak has brought with it the need for improved critical care for patients who develop severe disease. The majority of COVID-19 patients present with mild to moderate illness, 15% develop sever... more

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7 Ways Dentists Can Act Against Antibiotic Resistance

Centers for Disease Control and Prevention CDC (2019) C_CDC

Dentists are uniquely positioned to play a role in pre enting the spread of antibiotic resistance. Here are se en simple “how-tos” for safe, appropriate antibiotic prescribing and use when treating dental infections

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Epidemiological update: Monkeypox multi-country outbreak

European Centre for Disease Prevention and Control ECDC (2022) CC

9 June 2022. This report presents an update of monkeypox confirmed cases in the European Union/European Economic Area (EU/EEA) and worldwide

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Guidance on chlamydia control in Europe

European Centre for Disease Prevention and Control (2016) C1

This document updates the 2009 ECDC guidance on chlamydia control in Europe. It was developed by a technical expert group which conducted a critical review of the scientific evidence on the epidemiology of chlamydia and the effectiveness of screening programmes. The aim of this guidance is to suppo... more

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Interim guidance for healthcare providers and Zika virus laboratory diagnosis
recommended

European Centre for Disease Prevention and Control (2016) C1

This document aims to present an algorithm for deciding whom to test and provide guidance on the laboratory tests for Zika virus infection diagnosis in order to support clinical diagnostic and case reporting through surveillance among EU Member States. The algorithm is not intended for clinical man... more

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Redefining the Antibiotic Stewardship Team

Centers for Disease Control and Prevention CDC, American Nurses Association ANA (2017) C_CDC

Recommendations from the American Nurses Association/Centers for Disease Control and Prevention Workgroup on the Role of Registered Nurses in Hospital Antibiotic Stewardship Practices

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Implementation Guide for COVID-19 Vaccines in Africa
recommended

African Union; Africa CDC Centres for Disease Control and Prevention; World Health Organization WHO, et al. (2021) C1

“Guide to facilitate the implementation of the WHO/UNICEF “Guidance on developing a national deployment and vaccination plan for COVID-19 vaccines” for Africa t contains action-oriented lists of critical topics to address and checklists tailored to the context of African Union Member States. ... more

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Guideline for Disinfection and Sterilization in Healthcare Facilities

Centers for Disease Control and Prevention (CDC) (2019) C_CDC

The Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008, presents evidence- based recommendations on the preferred methods for cleaning, disinfection and sterilization of patient- care medical devices and for cleaning and disinfecting the healthcare environment. This docume... more

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Considerations relating to social distancing measures in response to the COVID-19 epidemic- second update

European Centre for Disease Prevention and Control ECDC (2020) C1

Social distancing is an action taken to minimise contact with other individuals; social distancing measures comprise one category of non-pharmaceutical countermeasures (NPCs)1 aimed at reducing disease transmission and thereby also reducing pressure on health services. This document builds upon exi... more

Guidance on pooled testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recommended

Guidance for Awake Prone Ventilation in the non-intubated Conscious Patient recommended

Interim guidance for healthcare providers and Zika virus laboratory diagnosis recommended

Implementation Guide for COVID-19 Vaccines in Africa recommended

Guidance on pooled testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
recommended

Guidance for Awake Prone Ventilation in the non-intubated Conscious Patient
recommended

Interim guidance for healthcare providers and Zika virus laboratory diagnosis
recommended

Implementation Guide for COVID-19 Vaccines in Africa
recommended