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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Generic risk assessment model for insecticide-treated nets, 2nd ed.

World Health Organization (WHO) (2018) C_WHO

Long-lasting insecticidal nets (LNs) constitute a core vector control intervention against malaria. A number of new LN products are under development and will require assessment of risks to humans. This document provides an updated generic model that can be used for the risk assessment of exposure t... more

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Model disability survey (MDS): survey manual

World Health Organization (WHO) & The World Bank (WB) WHO (2017) CC

The World Health Organization's Model Disability Survey (MDS) Manual is a tool to help implement the MDS in countries and to improve the quality of the interview process. This manual is intended to provide practical information about the survey instruments and their use during interviews. This manua... more

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WHO Guidance for Climate Resilient and Environmentally Sustainable Health Care Facilities
recommended

World Health Organization WHO (2020) C_WHO

The aim of this guidance is to enhance the capacity of health care facilities to protect and improve the health of their target communities in an unstable and changing climate; and to empower health care facilities to be environmentally sustainable, by optimizing the use of resources and minimizing ... more

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Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy

Tirados, I.; Esterhuizen, J.; Kovacic, V.; Mangwiro, TNC.; Vale, GA et al. PLOS Neglected Tropical Diseases (2015) CC

Sleeping sickness is controlled by case detection and treatment but this often only reaches less than 75% of the population. Vector control is capable of completely interrupting HAT transmission but is not used because of expense. We conducted a full scale field trial of a refined vector control tec... more

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Recognizing and responding to the effects of trauma A Discussion Guide for Health and Social Service Providers (Discussion Guide 2)

IWK Health Centre NOVA SCOTIA (2015) C1

This discussion guide is designed to assist individuals and agencies working toward developing trauma-informed approaches to service delivery. It describes how common traumatic experiences are for individuals accessing health and social services, and it provides information to help service prov... more

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WHO Monographs On Selected Medicinal Plants - Volume 4
recommended

World Health Organization WHO (2009) C_WHO

• provide scientific information on the safety, efficacy, and quality control/ quality assurance of widely used medicinal plants, in order to facilitate their appropriate use in Member States; • provide models to assist Member States in developing their own mono- graphs or formularies for these... more

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WHO manual for HIV drug resistance testing using dried blood spot specimens

World Health Organization WHO (2020) C_WHO

HIV-1 drug resistance (HIVDR) genotyping is an essential component of the WHO global HIVDR surveillance strategy. Plasma “gold standard” specimen type for HIVDR genotyping, but its use may not be feasible in rural, remote areas in low- and middle-income countries, since preparing and storing it ... more

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Clinic Supervisor Manual

Management Sciences for Health; USAID (2006) C1

This Clinic Supervisor’s Manual is helpful for focusing managers on the key elements of integrated primary health care as they simultaneously integrate new interventions for HIV/AIDS, tuberculosis, and malaria. This tool contains 12 sections. Section 1 explains how to use the manual. Section 2 hel... more

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Module: Other significant mental health complaints

WHO WHO (2015) C_WHO

Overview Learning objectives • Promote respect and dignity for people with other significant mental health complaints. • Know the common presentation of other significant mental health complaints. • Know the assessment principles of other significant mental health complaints. • Know the... more

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Environmentalism and Development in Catholic Social Teaching: a case of the Encyclical Laudato Si

Pavic, Z. ; Sundalic, A. Strossmayer J.J: et al. Research Gate (2016) C1

God. XXIX, BR. 2/2016. str. 323-334 In this paper an attempt has been made to contextualize the ecological dimension of contemporary Catholic social teaching. With this aim in mind, the authors discuss the merits of several theories and approaches (political economy approaches, ecological moderni... more

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WHO guidelines on good agricultural and collection practices (GACP) for medicinal plants

World Health Organization (WHO) (2003) C_WHO

The main objectives of these guidelines are to:
1. contribute to the quality assurance of medicinal plant materials used as the source for herbal medicines to improve the quality, safety and efficacy of finished herbal products; 2. guide the formulation of national and/or regional GACP guideli... more

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GUIDELINES FOR GOOD CLINICAL LABORATORY PRACTICES (GCLP)

Indian Council of Medical Research (ICMR) (2008) C1

Guidelines for Good Clinical Laboratory Practices (GCLP) outlines the principles and procedures to be followed by medical laboratories involved in clinical research and/or patient care so as to provide quality data which can be used for health research and patient treatment. As the use of laboratory... more

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WHO Operational package for assessing, monitoring and evaluating country pharmaceutical situations

WHO World Health Organization (2007) C_WHO

Guide for coordinators and data collectors - The WHO Operational Package for Assessing, Monitoring and Evaluating Country Pharmaceutical Situations is intended as a useful tool for researchers, policy-makers, planners and others who need to use standardized measurement tools to gather data and other... more

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The Health Literacy Toolkit For Low- and Middle-Income Countries

Sarity Dodson, Suvajee Good and Richard Osborne World Health Organization - Regional Office South-East Asia (2015)

A series of information sheets to help empower communities and strengthen health systems This series of information sheets introduces health literacy, its relevance to public policy, and the ways it can be used to inform the promotion of good health, the prevention and management of communicab... more

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Global report on diabetes World Health Organization 2016

World Health Organization WHO (2016) C_WHO

Diabetes is a serious, chronic disease that occurs either when the pancreas does not produce enough insulin (a hormone that regulates blood sugar, or glucose), or when the body cannot effectively use the insulin it produces. Diabetes is an important public health problem, one of four priority noncom... more

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Asthma Action Plan - U.S. Centers for disease Control an Prevention

U. S. Centers for Disease Control and Prevention (2024) CC2

Asthma Action Plan Doctor’s Name: Doctor’s Phone Number: Main Emergency Contact: Backup Emergency Contact: Green Zone: No coughing, wheezing, chest tightness, or shortness of breath. Can do usual activities: Every day: Take these medicines, even if you’re not having any symptoms. Av... more

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Standard operating procedure (SOP) for quality improvement

Aminul Hasan Quality Improvement Secretariat (2019) CC

This SOP describes specific step by step procedures in clinical management like OPD, IPD Housekeeping, Emergency services, OT services, Radiology Services & Pathology services. It should be used as a hands-on reference for service providers providing services, thereby helping to standardize the prac... more

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Sequencing of SARS-CoV-2 - first update

European Centre for Disease Prevention and Control ECDC (2021) CC

This technical guidance aims to provide guidelines to laboratories and relevant stakeholders in the European Union (EU), European Economic Area (EEA) and other countries in the WHO European region in making decisions on establishing sequencing capacities and capabilities, in making decisions on whic... more

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Ebola virus disease (EVD) – Key questions and answers concerning health care waste

World Health Organization (2021) C_WHO

Update September 2021. Safe management of health care waste practices play an essential role in protecting human health during all disease outbreaks, including during Ebola Virus Disease (EVD) outbreaks. This question and answer document provides practical, evidence-based recommendations on minimum... more

WHO Guidance for Climate Resilient and Environmentally Sustainable Health Care Facilities recommended

WHO Monographs On Selected Medicinal Plants - Volume 4 recommended

WHO Guidance for Climate Resilient and Environmentally Sustainable Health Care Facilities
recommended

WHO Monographs On Selected Medicinal Plants - Volume 4
recommended