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Can J Anesth/J Can Anesth June 2018, Volume 65, Issue 6, pp 698–708
Q1: What are the effective maternal mental health interventions to prevent developmental problems in early infancy?
PLoS Med 15(7): e1002615. https://doi.org/10.1371/journal. pmed.1002615
Developmental Disabilities
Institute of Medicine (US); Committee on Nervous System Disorders in Developing Countries; National Academy of Sciences
(2001)
C2
Neurological, Psychiatric, and Developmental Disorders: Meeting the Challenge in the Developing World
Institute of Medicine (US) Committee on Nervous System Disorders in Developing Countries.
Washington (DC): National Academies Press (US); 2001.
Perspectives on Drugs - Cocaine trafficking to Europe
European Monitoring Centre for Drugs and Drug Addiction
(2016)
C2
Fentanils and synthetic cannabinoids: driving greater complexity into the drug situation
European Monitoring Centre for Drugs and Drug Addiction
(2018)
C2
An update from the EU Early Warning System
Psychosocial interventions for the management of cannabis dependence [Updated 2015]
mhGAP; WHO
(2015)
C_WHO
SCOPING QUESTION: Which psychosocial interventions are effective in the management of cannabis dependence?
The ITHACA Toolkit for monitoring Human Rights and General Health Care in mental health and social care institutions
Institutional Treatment,Human Rights and CareAssessment (ITHACA)
Health Service and Population Research Department,Institute of Psychiatry, King's College London
(2010)
Policy in action
World Health Organization (Europe)
(2017)
C_WHO
A tool for measuring alcohol policy implementation
How to develop an action plan to implement the strategy
World Health Organization (Western Pacific Region)
(2009)
C_WHO
WHO Western Pacific Regional Strategy to Reduce Alcohol-Related Harm
Executive Summary - Chapter 3 Pharmacological Treatment
R. Ali
ATLAS on substance use (2010)— Resources for the prevention and treatment of substance use disorder; WHO
(2019)
C_WHO
ATLAS on substance use (2010)— Resources for the prevention and treatment of substance use disorder
Accessed: 14.03.2019
Executive Summary - Chapter 5 Policy and Legislation
R. Room
ATLAS on substance use (2010)— Resources for the prevention and treatment of substance use disorder; WHO
(2019)
C_WHO
ATLAS on substance use (2010) — Resources for the prevention and treatment of substance use disorders
Accessed: 14.03.2019
Global status report on alcohol and health 2018
World Health Organization
(2018)
C_WHO
Global strategy to reduce the harmful use of alcohol
World Health Organization
(2010)
C_WHO
The adoption and the entry into force of the Convention on the Rights of Persons with Disabilities and its Optional Protocol challenge such attitudes and mark a profound shift in existing approaches towards disability.
Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence
World Health Organization
(2009)
C_WHO
New heroin-assisted treatment - Recent evidence and current practices of supervised injectable heroin treatment in Europe and beyond
J. Strang; T. Groshkova; N. Metrebian
European Monitoring Centre for Drugs and Drug Addiction; Publications Office
(2019)
C2
EMCDDA Insights - 11
Accessed: 14.03.2019
As a public good, antimicrobial medicines require rational use if their effectiveness is to be preserved. However, up to 50% of antibiotic use is inappropriate, adding considerable costs to patient care, and increasing morbidity and mortality. In addition, there is compelling evidence that antimicro
...
bial resistance is driven by the volume of antimicrobial agents used. High rates of antimicrobial resistance to common treatments are currently reported all over the world, both in health care settings and in the community. For over two decades, the Region of the Americas has been a pioneer in confronting antimicrobial resistance from a public health perspective. However, those efforts need to be stepped up if we are to have an impact on antimicrobial resistance and want to quantify said impact.
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Patients with diabetes are at increased risk of developing cardiovascular disease (CVD) with its manifestations of coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF), and stroke, as well as aortic and peripheral artery diseases. In addition, diabetes is a major risk factor f
...
or developing chronic kidney disease (CKD), which in itself is associated with developing CVD. The combination of diabetes with these cardio-renal comorbidities enhances the risk not only for cardiovascular (CV) events but also for CV and all-cause mortality. The current European Society of Cardiology (ESC) Guidelines on the management of cardiovascular disease in patients with diabetes are designed to guide prevention and management of the manifestations of CVD in patients with diabetes based on data published until end of January 2023. Over the last decade, the results of various large cardiovascular outcome trials (CVOTs) in patients with diabetes at high CV risk with novel glucose- lowering agents, such as sodium–glucose co-transporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists (RAs), but also novel non-steroidal mineralocorticoid receptor antagonists (MRAs), such as finerenone have substantially expanded available therapeutic op-
tions, leading to numerous evidence-based recommendations for the management of this patient population.
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