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Rabies Clinical and Laboratory Diagnosis Advisory

Division of Public Health Surveillance and Response National Institute for Communicable Diseases (NICD) (2022) CC
Rabies is a fatal viral disease, but is preventable in humans. The rabies virus is transmitted to humans through virus-laden saliva from a rabid animal, mostly dogs. The virus is shed in the saliva of an infected animal and can be introduced into another body through bites, scratches and any other ... more
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Algorithm for laboratory diagnosis of Ebola virus disease

European Centre for Disease Prevention and Control (2014)
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Recommendations for laboratory diagnosis of TB during the COVID-19 pandemic

Pan American Health Organization PAHO, World Health Organization WHO (2020) C_WHO
Given the current situation of the COVID-19 pandemic, countries are advised to continue adopting the TB diagnostic algorithms recommended by PAHO / WHO. Despite the differences in the modes of transmission of TB and COVID-19, certain personal protection measures are relevant for both diseases. Rout ... more
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Buruli ulcer laboratory network and new external quality assessment programme for PCR-based diagnosis in the WHO African Region. Terms of reference

World Health Organization World Health Organization WHO (2020) C_WHO
A total of 18 laboratories from 13 countries participated in the four rounds of EQA: 10 laboratories from eight African endemic countries, four of which participated in all four rounds and three in three rounds. The overall results showed that the median performance of these laboratories improved ov ... more
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European Tuberculosis Laboratory Initiative Regional TB and MDR-TB Diagnosis Workshop Report

World Health Organization Europe (2017) C_WHO
Copenhagen, Denmark, 24–25 August 2017
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Establishing a national laboratory quality system for HIV diagnosis and monitoring in resource-limited settings: Experience from Senegal

Mbengue M.A.S., Moussa S., Papa A. D. et. al. African Journal of Laboratory Medicine (2016) C2
Senegal has adopted the World Health Organization–Joint United Nations Programme on HIV/AIDS recommended 90-90-90 targets.5 The adoption of this strategy means that the country is expected, by 2020, to have 90% of its population living with HIV diagnosed, 90% of all those diagnosed receiving susta ... more
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Zika virus (ZIKV) Surveillance in the Americas: Laboratory detection and diagnosis
recommended

Pan American Health Organization PAHO; World Health Organization, Regional Office for the Americas (2016) C_WHO
This algorithm is addressed to laboratories with established capacity(molecular, antigenic and/orserological) to detect dengue (DENV), Zika (ZIKV), and chikungunya(CHIKV) as part of the differential diagnosis for arborviruses. A BSL2 containmen ... more
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Interim guidance for healthcare providers and Zika virus laboratory diagnosis
recommended

European Centre for Disease Prevention and Control (2016) C1
This document aims to present an algorithm for deciding whom to test and provide guidance on the laboratory tests for Zika virus infection diagnosis in order to support clinical diagnostic and case ... more
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Expanding Access to Point-of-Care Early Infant Diagnosis: Implementation Approaches and Testing Strategies

American Society for Laboratory Medicine (ASLM); Clinton Health Access Initiative; Elizabeth Glaser Pediatric Health Foundation; et al. American Society for Laboratory Medicine (ASLM); Clinton Health Access Initiative; Elizabeth Glaser Pediatric Health Foundation; et al. (2018) C2
October 2018
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Buruli ulcer : diagnosis of Mycobacterium ulcerans disease : a manual for health care providers

F. Portaels; Johnson, P.; Meyers, W. World Health Organization WHO (2001) CC
This manual is to assist health care providers and laboratory scientists to diagnose mycobacterium ulcerans disease (Buruli ulcer). The manual aims to achieve a better understanding of the clinical presentation and its ... more
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Establishment of PCR laboratory in developing countries, 2nd ed.
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World Health Organization ( WHO), Regional Office for South-East-Asia (2016) C_WHO
Polymerase Chain Reaction (‎PCR)‎ has significantly helped in early diagnosis and commencement of specific interventions for diseases control. It also plays a critical role in understanding the disease epidemiology and unraveling the transmissio ... more
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Use of alternative interferon-gamma release assays for the diagnosis of TB infection: WHO policy statement

World Health Organization WHO (2022) C_WHO
Following review of evidence and advice from the Technical Advisory Group (TAG) on Tuberculosis (TB) Diagnostics and Laboratory Strengthening, the World Health Organization (WHO) announces that current WHO recommendations for the use of interferon- ... more
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Laboratory testing for dengue virus: interim guidance, April 2025
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World Health Organization WHO (2025) C_WHO
This guidance synthesizes current evidence on dengue laboratory testing and diagnostics and provides practical recommendations for laboratories, clinicians, public health officials, and programme managers involved in dengue ... more
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Laboratory Tests Used in the Diagnostic and Research of Dengue Virus: Present and Future

Juan Samuel Sulca Herencia IntechOpen (2018) CC
Dengue is a significant public health problem. There are four dengue virus serotypes identified; however, its diagnosis is difficult due to the existence of many viruses, bacteria, and parasites producing the same clinical presentation, being presen ... more
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Handbook on TB laboratory diagnostic methods in the European Union

European Centre for Disease Prevention and Control (2016) C1
The aim of this handbook is to provide network members and other laboratories involved in the diagnosis of tuberculosis, with an agreed list of key diagnostic methods and their protocols in various areas of TB ... more
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Laboratory testing for diphtheria in outbreak settings: Interim guidance, 26 January 2024

World Health Organization WHO (2024) C_WHO
This document provides detailed guidance on laboratory testing for suspected diphtheria cases during significant outbreaks or in low-resource settings. It aims to supplement and build on other existing WHO guidance documents on surveillance standard ... more
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Antigen-detection in the diagnosis of SARS-CoV-2 infection
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World Health Organization WHO (2021) C_WHO
Interim guidance, 6 October 2021 Direct detection of SARS-CoV-2 viral proteins (antigens) in nasal swabs and other respiratory secretions using lateral flow immunoassays (also known as rapid diagnostic tests, RDTs) offers a faster and less expensive method to test for SARS-CoV-2 than the reference ... more
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Training Manual on Diagnosis of Intestinal Parasites

WHO (1998) C_WHO
based on the WHO Bench Aids for the diagnosis of intestinal parasites; Tutor’s Guide: perform specific laboratory techniques; identify intestinal parasites by genus and species; quantify helminth ... more
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DHR-ICMR GUIDELINES FOR DIAGNOSIS AND MANAGEMENT OF RICKETTSIAL DISEASES IN INDIA

Indian Council of Medical Research (ICMR) (2015) C1
The present DHR-ICMR guidelines comprehensively address the various concerns regarding the clinical assessment, treatment, and laboratory diagnosis of rickettsial diseases in India and the world. It ... more
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GUIDELINES FOR GOOD CLINICAL LABORATORY PRACTICES (GCLP)

Indian Council of Medical Research (ICMR) (2008) C1
Guidelines for Good Clinical Laboratory Practices (GCLP) outlines the principles and procedures to be followed by medical laboratories involved in clinical research and/or patient care so as to provide quality data which can be used for health resea ... more