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Dr. Md. R. Karim

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Duke University

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FIND

G. K. Siberry

Government of People’s Republic of Bangladesh, Ministry of Health and Family Welfare, Directorate General of Health Services ...

GOVERNMENT OF SIERRA LEONE MINISTRY OF HEALTH AND SANITATION

Government of the People's Republic of Bangladesh DGHS Directorate General of Health Services Ministry of Health and Family Welfare

H.L. Nguyen

I. T. Katz

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J. E. Haberer

Langwenya, Nontokozo

LaRocque, R.

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Phillips, Tamsin K.

Phimemon, Rune N., Michael J. Mahande, and Habib O. Ramadhani

Prof. AHM E. Hussain

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Radcliffe

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World Health Organization

World Health Organization (WHO), Regional Office for South-East Asia

Yebyo, Henock G., Mussie A. Gebreselassie, and Alemayehu B. Kahsay

Publication Years

2020-2025

2010-2019

2000-2009

1990-1999

Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes

Park, J.J. Diabetes & Metabolism Journal (2021) CC

The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients wit ... h DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes. more

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Same‐day antiretroviral therapy (ART) initiation in pregnancy is not associated with viral suppression or engagement in care: A cohort study

Langwenya, Nontokozo; Phillips, Tamsin K.; Brittain, Kirsty et al. (2018) CC

Journal of the International AIDS Society Vol. 21 (2018) e25133
Many prevention of mother-to-child HIV transmission programmes across Africa initiate HIV-infected (HIV positive) pregnant women on lifelong antiretroviral therapy (ART) on the first day of antenatal care (“same-day” initiation ... ). However, there are concerns that same-day initiation may limit patient preparation before starting ART and contribute to subsequent non-adherence, disengagement from care and raised viral load. We examined if same-day initiation was associated with viral suppression and engagement in care during pregnancy.
The data suggest that same-day ART initiation during pregnancy is not associated with lower levels of engagement in care or viral suppression through 12 months post-delivery in this setting, providing reassurance to ART programmes implementing Option B+.
https://doi.org/10.1002/jia2.25133 more

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Bangladesh Health System Review

Asia Pacific Observatory on Health Systems and Policies (2015) C1

Health Systems in Transition. Vol. 5 No.3 2015

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