BACKGROUND: Growing political attention to antimicrobial resistance (AMR) offers a rare opportunity for achieving meaningful action. Many governments have developed national AMR action plans, but most have not yet implemented policy interventions to reduce antimicrobial overuse. A systematic evidenc...e map can support governments in making evidence-informed decisions about implementing programs to reduce AMR, by identifying, describing, and assessing the full range of evaluated government policy options to reduce antimicrobial use in humans.
METHODS AND FINDINGS: Seven databases were searched from inception to January 28, 2019, (MEDLINE, CINAHL, EMBASE, PAIS Index, Cochrane Central Register of Controlled Trials, Web of Science, and PubMed). We identified studies that (1) clearly described a government policy intervention aimed at reducing human antimicrobial use, and (2) applied a quantitative design to measure the impact. We found 69 unique evaluations of government policy interventions carried out across 4 of the 6 WHO regions. These evaluations included randomized controlled trials (n = 4), non-randomized controlled trials (n = 3), controlled before-and-after designs (n = 7), interrupted time series designs (n = 25), uncontrolled before-and-after designs (n = 18), descriptive designs (n = 10), and cohort designs (n = 2). From these we identified 17 unique policy options for governments to reduce the human use of antimicrobials. Many studies evaluated public awareness campaigns (n = 17) and antimicrobial guidelines (n = 13); however, others offered different policy options such as professional regulation, restricted reimbursement, pay for performance, and prescription requirements. Identifying these policies can inform the development of future policies and evaluations in different contexts and health systems. Limitations of our study include the possible omission of unpublished initiatives, and that policies not evaluated with respect to antimicrobial use have not been captured in this review.
CONCLUSIONS: To our knowledge this is the first study to provide policy makers with synthesized evidence on specific government policy interventions addressing AMR. In the future, governments should ensure that AMR policy interventions are evaluated using rigorous study designs and that study results are published.
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This manual provides guidance for policymakers on the issue of prehospital trauma care systems. The main areas covered include the organisation of the prehospital trauma care system, capacity development, data collection, transportation and communication, as well as ethical and legal considerations
R4D conducted a thorough desk review and qualitative fiscal space analysis, 19 interviews about financing for the three diseases and the extent of alignment between public financial management systems and health policy objectives, and a validation workshop with government officials.
Tanzania’...s disease response faces a triple transition challenge: replacing donor funding, closing the resource gap that would exist even with donor funding, and more efficiently delivering on disease response objectives.
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Assessment and Guidance for Strengthening Integration of Mental Health into Primary Health Care and Community-Based Service Platforms in Ukraine
This report presents operational recommendations based on monthly COVID-19 online and offline community feedback trends analysis in Africa.It aims to enable evidence-based decision-making at
regional and national levels.
PLOS ONE | https://doi.org/10.1371/journal.pone.0210937
February 5, 2019
This factsheet describes the work and activities of the Center for Disease Control and Prevention (CDC) in Mozambique as well as its impact in this country.
In Numbers
2.1 million affected people, of which 894,000 are children.
1.4 million people require humanitarian assistance.
806,000 people severely food insecure.
This technical note contains indicators and minimum standards necessary for emergency response in the following topics: quantity of water, access to water, quality of water, sanitation, hygiene, solid waste, cleaning and disinfection, as well as dosages for the preparation of solutions disinfectants... using sodium hypochlorite.
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Teaching the Sustainable Development Goals” provides information about the SDGs, their background, the global reality and offers assistance and suggestions on how to teach and support learning for sustainable development.
Lessons learned from an M&E task-shifting initiative in Botswana
The Rwandan Health Sector Research Policy (HSRP) policy defines the scope of research in the Rwandan health sector and presents the strategic principles to ensure that the research done in Rwandan health sector will be conducted in a more coordinated manner, promoting research for equity and social ...justice and to benefit the Rwandan community as well as the global community in general. The health sector research policy provides solutions to the challenges which have been identified in health research. It will support and improve Rwanda’s health research environment and create a space and framework in which health research will grow and support improved health outcomes in Rwanda. It gives a clear orientation for dissemination and use of results. For sustainability of health research in Rwanda, foreign researchers are called upon to collaborate with Rwandans with clear capacity building plans.
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We systematically reviewed Medline as well as the references of published review articles for relevant studies of adherence to multidrug treatment of both drug-susceptible and drug-resistant TB through February 3, 2018. We included randomized controlled trials (RCTs) as well as prospective and retro...spective cohort studies (CSs) with an internal or external control group that evaluated any adherence intervention and conducted a meta-analysis of their impact on TB treatment outcomes. Our search identified 7,729 articles, of which 129 met the inclusion criteria for quantitative analysis. Seven adherence categories were identified, including DOT offered by different providers and at various locations, reminders and tracers, incentives and enablers, patient education, digital technologies (short message services [SMSs] via mobile phones and video-observed therapy [VOT]), staff education, and combinations of these interventions.
https://doi.org/10.1371/journal.pmed.1002595
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First edition, November 1997 | Revised July 2002
SAMJ Review Vol. 108 No.3
PLOS ONE | DOI:10.1371/journal.pone.0144057 December 14, 2015