Cryptococcal disease is one of the most common opportunistic infections among people living with advanced HIV disease and is a major contributor to severe illness, morbidity, and mortality, particularly in sub-Saharan Africa.
These guidelines update the recommendations that were first released i...n 2018 on diagnosing, preventing, and managing cryptococcal disease. In response to important new evidence that became available in 2021, these new guidelines strongly recommend a single high dose of liposomal amphotericin B as part of the preferred induction regimen for the treatment of cryptococcal meningitis in people living with HIV. This simplified regimen - a single high dose of liposomal amphotericin B paired with other standard medicines (flucytosine and fluconazole) - is as effective as the previous WHO standard of care, with the benefits of lower toxicity and fewer monitoring demands.
The objective of these guidelines is to provide updated, evidence-informed recommendations for treating adults, adolescents and children living with HIV who have cryptococcal disease. These guidelines are aimed at HIV programme managers, policymakers, national treatment advisory boards, implementing partners and health-care professionals providing care for people living with HIV in resource-limited settings with a high burden of cryptococcal disease.
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After a decade of crisis, Syria remains one of the world’s most complex humanitarian crises. Continued hostilities, new and protracted displacement, increased returns and the sustained destruction of communities have impacted Syrians’ lives and futures in a devastating way. The 2021 Humanitarian... Needs Overview (HNO) identified that 13.4 million people, more than half of country’s pre-crisis population, need humanitarian support. Of this figure, 12.4 million require health care.
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Heatwaves, or heat and hot weather that can last for several days, can have a significant impact on society, including a rise in heat-related deaths. Heatwaves are among the most dangerous of natural hazards, but rarely receive adequate attention because their death tolls and destruction are not alw...ays immediately obvious
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The global proportion of people at risk to heat stress is increasing. The Lancet Countdown is tracking our exposure and vulnerability to changes in heat caused by climate change.
Climate Central communicates climate change science, effects, and solutions to the public and decision-makers.
Each toolkit includes science explainers and curated resources to help understand extreme events—from their links to our warming climate to their local impacts.
Menschenhandel liegt vor, wenn eine Person unter Ausnutzung ihrer Zwangslage in eine Ausbeutungssituation gebracht wird. Dies kann in verschiedenen Formen und Bereichen erfolgen: ausbeuterische Arbeitsverhältnisse, sexuelle Ausbeutung, Ausbeutung in der Ehe, Ausbeutung der Betteltätigkeit, Ausbeut...ung strafbarer Handlungen, erzwungene Organentnahme. Menschenhandel ist ein schwere Menschenrechtsverletzung und ein Verstoß gegen die Unversehrheit der Menschenwürde.
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Informationsplattform rund um Affenpocken
Seit Mai 2022 treten in Europa und auch in Deutschland Fälle von Affenpocken auf. Die Betroffenen erkranken in der Regel nicht schwer. Aktuelle Informationen über Ansteckung, Symptome, Schutz und Impfung gibt es hier.
This technical report summarizes the discussions on the status of programmatic transition to tenofovir, lamivudine and dolutegravir (TLD) in low– and middle- income countries, addressing the best practices and major challenges faced by HIV programmes.
The latest data on safety and efficacy of do...lutegravir (DTG) containing regimens were also reviewed. The document identified the remaining gaps in knowledge, research, monitoring, and surveillance on DTG and TLD transition and listed the future priorities.
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Discover approaches and advances in our fight against the malaria mosquito using Insecticide Resistance Management (IRM).
On this three-week course, you’ll examine the rise of insecticide resistant mosquitoes and the resultant need for a new approach in the world’s fight against malaria transmi...ttance.
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The Americas region hosts more than 18.4 million refugees, asylum-seekers, displaced and stateless people, representing some 20 per cent of persons of concern to UNHCR worldwide. During the last two years, the coronavirus disease (COVID-19) pandemic has had a disproportionate impact on refugees and ...migrants in host communities, including loss of livelihoods opportunities, an increase in evictions, engagement in negative coping mechanisms, discrimination and xenophobia. Further compounded by limited access to regularization and documentation in some countries, these impacts have contributed to onward movements of people in search of protection and/or better opportunities elsewhere.
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This Practitioner Note is part of a four-part series providing MENA governments and practitioners in the fields of both social protection and disaster risk management (DRM) with general guidelines for future shock response informed by lessons learned from the COVID pandemic. The first three notes of... the series include recommendations on inclusive design and implementation related to the following topics: (i) targeting, identification and registration mechanisms; (ii) transfer values and payment modalities; and (iii) communication, case management and grievance redress mechanisms
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Consultancy Report May 2022
Here is what you need to know about monkeypox
This technical brief aims to support these trends, accelerated by the COVID-19 pandemic, and improve PrEP uptake, persistence, and effective use by providing implementation guidance for differentiated and simplified service delivery. The brief aims to support a range of stakeholders in planning and ...implementing PrEP services and supplements and updates previously published WHO PrEP implementation guidance.
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The updated guidelines present a standard minimum dataset, priority indicators and recommendations to strengthen data use across HIV prevention, testing and treatment, and linkages to services for sexually transmitted infections, viral hepatitis, tuberculosis and cervical cancer. The guidelines also... cover the use of routinely collected data for HIV surveillance (including measurement of HIV prevalence and incidence) and emphasize the use of data from different sources to gain a better picture of epidemiologic trends. The whole collection you can download from here https://www.who.int/publications/i/item/9789240055315
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The updated guidelines present a standard minimum dataset, priority indicators and recommendations to strengthen data use across HIV prevention, testing and treatment, and linkages to services for sexually transmitted infections, viral hepatitis, tuberculosis and cervical cancer. The guidelines also... cover the use of routinely collected data for HIV surveillance (including measurement of HIV prevalence and incidence) and emphasize the use of data from different sources to gain a better picture of epidemiologic trends.
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This document aims to provide interim guidance for microbiology and virology experts, other laboratory professionals, laboratory managers, infectious disease programme managers, public health professionals and other stakeholders that provide primary, confirmatory or advanced testing for SARS-CoV-2, ...including genomic sequencing, or are involved in making decisions on establishing or scaling up capability and capacity to detect and characterize circulating SARS-CoV-2 variants.
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