The document “Paving the Way for One Health: Highlights of the Global Programme Pandemic Prevention and Response, One Health” presents the work and achievements of the global programme implemented by the German development agency GIZ to strengthen pandemic prevention using the One Health approach. The report highlights how collaboration between the human health, animal health, and environmental sectors can help detect and prevent zoonotic diseases before they spread. It describes activities carried out in partner countries, such as improving surveillance systems, strengthening laboratory capacities, supporting cross-sector cooperation, and building the skills of health professionals. The document also showcases practical examples and project results that demonstrate how integrated One Health strategies contribute to better preparedness and more effective responses to future health threats. Overall, the report illustrates how international cooperation and interdisciplinary approaches can reduce the risk of pandemics and improve global health security.