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The federally approved clinical practice guidelines for HIV/AIDS are developed by panels of experts in HIV care. More information about the panels can be found in each set of guidelines. The recommendations in these guidelines represent the current, evidence-based consensus of the U.S. Departmen ... more
The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations. The guidelines were updated to comply with Executive Orders
The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV document is published in an electronic format and updated as relevant changes in prevention and treatment recommendations occur.
Full Guidelines
Dosing Recommendations for Prevention and Treatment
Archives of Medicine vo.7 no.5:10 Individuals infected with human immunodeficiency virus (HIV) often develop multiple complications and comorbidities, among them, opportunistic infections. The highest incidence of opportunistic infections was reported in the group of patients with CD4 lymphocyte ... more
The Department of Global HIV, Hepatitis and Sexually Transmitted Infections Programmes leads the development and implementation of the global health sector strategies on HIV, viral hepatitis, and sexually transmitted infections for ending AIDS and the epidemics of viral hepatitis and STIs by 2030
IAS–USA Topics in Antiviral Medicine. September 22, 2025
J Infect Dev Ctries 2023; 17(7):1022-1029. doi:10.3855/jidc.15105 Opportunistic co-infections are more prevalent in HIV-infected patients with a CD4 + cell count of < 200 cells/mm3, poor drug adherence, and also associated with the occupation. So, regular examination and appropriate medication can reduce the prevalenc ... more
The leishmaniases are a group of diseases caused by Leishmania spp., which occur in cutaneous, mucocutaneous and visceral forms. They are neglected tropical diseases (NTDs), which disproportionately affect marginalized populations who have limited access to health care. HIV co-infected patients with ... more
Severe bacterial infections are a leading cause of morbidity and mortality among people with advanced HIV disease, after tuberculosis and cryptococcal disease. For countries to reach the end-AIDS targets for 2030, there is a need to establish a roadmap for managing severe bacterial infections and re ... more
Cryptococcal disease, particularly cryptococcal meningitis is a significant cause of morbidity and mortality among people living with HIV with advanced HIV disease. It is estimated that it is responsible for nearly 19% of AIDS-related mortality, second only to tuberculosis. Rapid screening, diagnosi ... more
The Consolidated guidelines on HIV, viral hepatitis and STI prevention, diagnosis, treatment and care for key populations outline a public health response for 5 key populations (men who have sex with men, trans and gender diverse people, sex workers, people who inject drugs and people in prisons and ... more
An overview of validation structures and responsibilities at national, regional and global levels. This governance document supplements the global guidance document. Validation of elimination requires rigorous assessment at the national, regional and global levels of the impact and process indicato ... more
Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum. This disease is highly endemic in some regions of North America, Central America, and South America and is also reported in certain countries of Asia and Africa. It often affects people with impaired immunity, including people ... more
Over 2 million children worldwide are living with HIV infection and 95% reside in sub-Saharan Africa with the majority infected through mother-to-child transmission. Infected children have a high mortality with 50% dying by 2 years of age. Their clinical presentation includes common childhood infect ... more