As a lower-middle-income country (LMIC), South Africa (SA) bears the burden of maternal and neonatal mortality similar to other sub- Saharan African countries. According to the Saving Mothers Report 2017/19, there has been a progressive and sustained reduction in institutional maternal mortality (iMMR) in the past three triennia (2010-2019), from 320 per 100,000 live births to 120 per 100,000 live births. According to the Rapid Mortality Survey, the country’s infant mortality rate has declined from 29 deaths per 1000 live births in 2014 to 25 deaths per 1,000 live births in 2018. The institutional neonatal death rate showed a slight decrease from 12,7 deaths per 1,000 live births in 2016 to the current level of 12 per 1,000 live births and has remained static at this level for the past three years (saDHIS). Working towards the Sustainable Development Goal (SDG) of reducing maternal mortality to below 70 per 100 000 live births and neonatal mortality to 12 deaths per 1000 live births, South Africa aims to reduce institutional maternal mortality, neonatal mortality and stillbirths by 50% by 2030. This Maternal, Perinatal and Neonatal Health Policy provides a framework for the delivery of quality, comprehensive, and integrated MNH services and will guide the development and review of guidelines and related MNH interventions, including strengthening of the service delivery platform, governance, leadership and accountability for the provision of quality MNH services, development of advocacy messages, and guiding civil society priorities and community initiatives. The policy will also guide the development and review of academic curricula and the setting of research priorities.