In the past week, from 23 to 29 September, 20 new confirmed Ebola virus disease (EVD) cases, with an additional 12 deaths and an additional three probable cases validated from late August/early September, have been reported from seven health zones in two affected provinces in the Democratic Republic of the Congo. This perceived decrease in the number of cases should be interpreted with caution, as operational and security challenges in certain health zones make it difficult to undertake case detection and response functions. An increase in the number of reported cases is expected in the coming weeks once response activities resume in full.