The earlier initiation and expanded access to antiretroviral therapy have significantly reduced the devastating impact of the global HIV epidemic in recent decades. The HIV infection has become a chronic disease, and people living with HIV (PLHIV) are now surviving, ageing, and requiring lifelong care and treatment. Across all age groups, PLHIV are at risk of developing chronic complications and comorbidities, such as noncommunicable diseases and mental health disorders. These conditions may be pre-existing, HIV-associated or due to ageing.