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Multiple first-line therapies as part of the response to antimalarial drug resistance

World Health Organization WHO (2024) C_WHO
Effective malaria case management requires quick access to diagnostics and antimalarial treatments to reduce illness and death. Artemisinin-based combination therapy (ACT) has been essential to malaria treatment since 2001, as it combines artemisinin for rapid parasite reduction with a partner drug ... more
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Polio Global Eradication Intiative (2010)
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Coronavirus disease (COVID-19) - First Line Facility Management of Possible COVID-19

Western Cape Government (health); Practical Approach to Care Kit (PACK); University of Cape Town; Knowledge Translation Unit (University of Cape Tow Lung Institute) Western Cape Government (health); Practical Approach to Care Kit (PACK); University of Cape Town; Knowledge Translation Unit (University of Cape Tow Lung Institute) (2020) C2
Updated 20 March 2020
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EPI 2: First-line anti-epileptic medication for management of acute convulsive seizures, when intravenous access is available [2015]

mhGAP; WHO (2015) C_WHO
SCOPING QUESTION: In adults with acute convulsive seizures, where intravenous access is available, which first-line anti- epileptic medication should be used to abort seizures when compared to comparator?
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Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV - Interim Guidelines

World Health Organization (WHO) World Health Organization (WHO) (2018) C_WHO
Supplement to the 2016 consolidated Guidelines on the use of antiretroviral drugs for Treating and Preventing HIV infection HIV Treatment
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Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV - Policy Brief

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Holding the line: communities as first responders to COVID-19 and emerging health threats

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Update of recommendations on first- and second-line antiretroviral regimens

World Health Organization (WHO) World Health Organization (WHO) (2019) C_WHO
July 2019 Policy brief HIV Treatment
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National Guidelines on Second-line and Alternative First-line ART For Adults and Adolescents May 2013

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Update of recommendations on first- and second-line antiretroviral regimens - Policy Brief

World Health Organization (2019) C_WHO
HIV Treatment
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Treatment of tuberculosis - Annex 6 Essential first-line antituberculosis drugs

World Health Organization (2017) C_WHO
Guidelines for treatment of drug-susceptible tuberculosis and patient care Uptsate 2017
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Pretreatment drug resistance and new treatment paradigms in firstline ART

Moorhouse, M. Southern African HIV Cinicans Society (2018) C2
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Standard operating procedure (SOP) for health care in COVID-19 first line treatment centres (CFLTC)

Department of Health & Family Welfare Government of Kerala (2020) CC
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Evidence summary: systematic review of oral fexinidazole as first line treatment for rhodesiense Human African Trypanosomiasis

World Health Organization WHO (2024) C_WHO
Guidelines for the treatment of human African trypanosomiasis. Web Annex A. Commissioned by WHO Cochrane Response
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Recognizing neglected tropical diseases through changes on the skin: a training guide for front-line health workers
recommended

World Health Organization WHO (2018) C_WHO
The skin of a patient is the first and most visible structure of the body that any health-care worker encounters during the course of an examination. To the patient, it is also highly visible, and any disease that affects it is noticeable and will have an impact on personal and social well-being. Th... more
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Number of Triatominae species identified, at first administrative level

World Health Organization WHO (2020) CC
The boundaries and names shown and the designations used on this map do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its fr... more
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Web annex e. recommendations for use of hormonal contraception for women living with HIV using antiretroviral therapy (ART)

World Health Organization (2018) C_WHO
Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV: interim guidelines. Supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infe... more
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Environmental cleaning and infection prevention and control in health care facilities in low- and middle-income countries

World Health Organisation (WHO) (2023) C_WHO
Those who clean are the first line of defense against health care-associated infections (HAIs), and support efforts to reduce antimicrobial resistance (AMR). Strengthening the training of this important group can contribute to resolving many of today’s public health challenges. This is importan... more
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Group Interpersonal Therapy (IPT) For Depression

World Health Organization WHO (2016) C_WHO
WHO recommends interpersonal therapy (IPT) as a possible first line treatment for depression. With this new manual, the World Health Organization (WHO) gives guidance on the use of interpersonal therapy (IPT) using a 8 session group protocol. The manual - which is part of WHO’s mhGAP programme - d... more
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Falling short

International Union Against Tuberculosis and Lung Disease; Treatment Action Group; msh; ec al. (2017)
Ensuring Access to Simple, Safe and Effective First-Line Medicines for Tuberculosis. Accessed in November 2017.