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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Adolescent HIV Care and Treatment: A Training Curriculum for Health Workers . Module 12 Participant

ICAP; CDC; University Teaching Hospital, et al. (2011)

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Guidelines for antiretroviral therapy in Ghana

Ghana AIDS Commission (2010) C1

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Uganda: Food Security and Nutrition Assessment Karamoja Region, June 2015

World Food Programme, UNICEF (2015)

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Shaping the Future: How Changing Demographics Can Power Human Development

Palanivel, T. , et al. United Nations Development Programme (2016) C1

Asia-Pacific Human Development Report

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A glimpse into WHO work in Botswana

World Health Organisation (WHO) (2023) C_WHO

This publication articulates the WHO Botswana Country Office’s focus and investment needs for the biennium 2022–2023, building on achievements, networks, and partnerships fostered in 2020-2021. As the leading health authority within the United Nations system in Botswana, the WHO Country Offi... more

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Disability and Education. Summary of Results

Jacob R.S. Malungo, D. Nabuzoka, R. Paul, et al. UNICEF; Ministry of Community Development and Social Services Zambia, et al. (2018)

Qualitative study from Zambia on barriers to and facilitators of life-long learning

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Quick Tips on COVID-19 and Migrant, Refugee and Internally Displaced Children (Children on the Move)

UNICEF (2020) C_UNICEF

This document will be continuously updated. Version as of April 27th, 2020 Migrant and displaced children are at heightened risk to the immediate and secondary impacts of COVID-19. They often live in cramped conditions with limited access to water, sanitation, and hygiene (WASH), may be in immig... more

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Maintaining and prioritizing HIV prevention services in the time of COVID-19

UNAIDS; GPC (2020) CC

In the time of coronavirus disease (COVID-19), sex and drug use will continue, regardless of physical distancing orders and policies. People who previously met in community gathering venues such as bars and clubs may now meet in different sites, ones that are “hidden” or less accessible. This, i... more

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Ethical Decision-Making in Humanitarian Health in Situations of Extreme Violence. Report and Recommendations

Johns Hopkins Bloomberg School of Public Health , Syrian American Medical Society, et al. (2019) C1

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Control of Communicable Diseases And Prevention of Epidemics

World Health Organization (2002)

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Census 2011 Profile of persons with disabilities | Statistics South Africa

Statistics South Africa (2014) CC

Stats SA has released an in-depth report on persons with disabilities. The report, written using Census 2011 data, is the first in a series of in-depth analyses of various Census 2011 variables, such as ageing and education. The report provides statistical evidence relating to the prevalence of dis... more

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Ending the AIDS epidemic for adolescents, with adolescents

UNAIDS (Joint United Nations Programme on HIVAIDS); Unicef; United Nations Educational, Scientific and Cultural Organization; et al. UNAIDS (Joint United Nations Programme on HIVAIDS); Unicef; United Nations Educational, Scientific and Cultural Organization; et al. (2016) C2

A practical guide to meaningfully engage adolescents in the AIDS response UNAIDS 2016 reference

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Terminology and Information on Drugs

United Nations Office on Drugs and Crime UNODC United Nations (2016) CC

Third edition

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Philippines: National Objectives for Health 2011 - 2016

Department of Health (DOH) (2012) C1

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Framework for Operations and Implementation Research in Health and Disease Control Programs

World Health Organization; The Global Fund; UNAIDS; eta al. (2009)

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The Cost of Security Risk Management for NGOs

Finucane, C.; European Interagency Security Forum (EISF) (2013) C2

The Cost of Security Risk Management for NGOs explores the costs related to safety and security management for aid programmes. It aims to assist all aid practitioners to determine their risk management expenditure more accurately, and demonstrate an evidence-based approach when presenting this infor... more

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To Stay and Deliver - Good practice for humanitarians in complex security environments

Jan Egeland, Norwegian Institute of International Affairs; Adele Harmer and Abby Stoddard, Humanitarian Outcomes Office for the Coordination of Humanitarian Affairs (OCHA) (2011) C2

The report offers an analysis of the broader challenges to securing humanitarian action and recommends areas for improvement. This study will contribute to improving the way humanitarians ‘do business’ in complex security environments. Document also available in French, Arabic and Spanish.

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TB prevention and control care in prisons

M. Doara, D. Choroliani, P. de Colombani World Health Organization, Europe (2014) C_WHO

Chapter 8, Prison and Health, published

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Rwanda: July 2014 – June 2015 Annual Report - Tuberculosis and Other Respiratory communicable Diseases Control in Rwanda

Rwanda Biomedical Center - Institute of HIVAIDS, Disease prevention & Control (IHDPC), TB & Other Respiratory Communicable Diseases Division (2015) C2

This report has been developed, based on data provided by the TB & ORD surveillance system from across Rwanda. It provides a comprehensive picture of the occurrence and management of TB & ORD and Leprosy in Rwanda. It is structured based on the 2013-2018 Rwanda TB national strategic plan (2013-2018 ... more