Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Each unit builds on the one prior, and they all combine to provide key information for developing an SBCC strategy. It is not essential, however, to work through the I-Kit from start to finish. Users can choose to focus on specific aspects for which they need support in their emergency communication... response. The nine units and corresponding worksheets are outlined in the I-Kit Site Navigator.
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UNICEF’s support for data collection: the Multiple Indicator Cluster Surveys (MICS)
The main objectives of the SOPs are to: (i) establish standards and timelines for response activities; and (ii) guide national governments and GPEI partners in key support functions.
This new version of the SOPs presents overall response requirements for dealing with type 1, 2 and 3 poliovirus fo...llowing monovalent type 2 oral polio vaccine (mOPV2) cessation. Version 2.4 will be valid until release of revised version 3.0 (anticipated May 2018).
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This Guide provides practical guidance for governments regarding how to effectively communicate with communities during the recovery phase following an emergency. It explains how to identify communication needs, and presents “best fit” communication methods and strategies to deploy to support Di...saster Recovery Frameworks (DRF) and recovery strategies.
The Guide is divided into six sections, as follows:
SECTION 1 Good Practice Principles for Effective Communication
SECTION 2 Barriers to Effective Communication
SECTION 3 How to Identify Communication Needs during Recovery
SECTION 4 Communication Methods for Recovery Planning and Operations
SECTION 5 Developing a Communication Plan
SECTION 6 Key Take-away Messages
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Trauma can affect a refugee child on an individual, classroom, school, and family level. However, just because a student is a refugee, it does not mean he or she has experienced trauma and/or will exhibit symptoms related to trauma. Many refugee children adjust very well to new school settings and o...ften quickly pick up language and cultural norms in the school setting.
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This guide is an introduction on how to integrate logistics management information systems (LMIS) with geographic information systems (GIS). It covers the value of integrating these two systems, the steps in assessing if it is currently viable to link the systems, how to set the linkage, the process...es for using LMIS within a GIS platform, and finally how to sustain the linkage. The aim of this guide is to assist logistics managers, decisionmakers and technical experts in understanding the value of integrating GIS and of the process involved in integrating these two systems.
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Accessed Online January 2019
Для того чтобы помочь разобраться с детской психиатрической генетикой, мы сначала представим основные концепции общей генетики. Это послужит краткой ознакомител...ной информацией о том, как психиатрические проблемы передаются от родителей их детям. Далее мы обсудим важность обследования семей так, чтобы можно было получить информацию как о генетике, так и о влия-нии окружающей среды. Затем мы опишем разные типы научных исследований в генетике и расскажем, как интерпретировать их результаты.
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Recomendaciones para la eleboració de protocolos en países de bajos ingresos
Independent Monitoring Board of the Global Polio Eradication Initiative (Twelfth Report: October 2015)