The document titled "Checklist for Assessing Management of Severe Malaria" is part of the MalariaCare Toolkit. It provides a structured tool for supervisors conducting outreach training and supportive supervision (OTSS) visits in healthcare facilities. The checklist is designed to evaluate and guide... the clinical management of severe malaria cases, including diagnostics, treatment planning, complication management, patient monitoring, and the administration of injectable artesunate. It also includes sections for direct observation of clinical procedures and supervisor feedback to help improve healthcare worker performance and adherence to national treatment guidelines.
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La thèse de Yobouet Inès Kouakou, soutenue à l’Université Claude Bernard Lyon 1, porte sur le traitement d’urgence du paludisme sévère chez l’enfant à l’aide d’une administration intranasale d’artésunate. L’objectif principal de ce travail est d’explorer, in vitro, la voie na...sale comme alternative à la voie intra-rectale recommandée actuellement en pré-hospitalier. L’étude démontre la non-toxicité de formulations d’artésunate sur un modèle de muqueuse nasale humaine, bien que la perméation observée reste faible. Des pistes sont proposées pour améliorer cette perméation, notamment par l’optimisation galénique. La thèse inclut également une revue de la pharmacocinétique de l’artésunate et le développement de méthodes de dosage simples et peu coûteuses, adaptées aux laboratoires à ressources limitées. Ce travail s’inscrit dans une démarche de lutte contre le paludisme, notamment en zones rurales où l’accès aux soins reste difficile.
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Accessed January 13, 2025
Welcome to our implementation research case example focusing on chagas disease and Ecuador. This module offers a comprehensive exploration of the strategies employed to address the challenges posed by Chagas disease, a neglected tropical disease prevalent in Latin America. With a specific focus on t...he southern Ecuador context, this course describes the relationship between public health interventions, socioeconomic factors, and community understanding, all of which are essential for the prevention, treatment, and diagnosis of chagas disease
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This case study in Chile focused on the following two strategic levers of the WHO/UNICEF PHC Operational Framework during the implementation period 2022–2023: “Political Commitment and Leadership” and “Governance and Policy Frameworks”. This included examining how support from the three le...vels of the Organization (WHO headquarters, Pan American Health Organization (PAHO)/WHO Regional Office for the Americas and PAHO/WHO Chile Country Office) has been coordinated and operationalized. The case study also explored how, through these two strategic levers, catalytic actions have been planned and implemented in relation to other operational levers, in particular “Models of care”.
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The Regional Child Protection Operational Note has been developed by IOM and UNICEF’s Regional and Country Offices in North, West and Central Africa as a collaborative inter-agency and cross-regional endeavour within the framework of the sixth phase of the IOM Regional Development and Protection P...rogramme (RDPP) for North Africa, a regional initiative funded by the European Union through the Directorate‑General for Migration and Home Affairs and the Italian Ministry of Interior.
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ith a view to support the monitoring and reporting on the denial of humanitarian access against children, the Office of the Special Representative of the Secretary-General for Children and Armed Conflict and UNICEF publish today* a guidance note offering new tools to practitioners to better address ...this violation of children's rights in conflict situations. The Denial of Humanitarian Access (DHA) is one of six grave violations against children monitored by the United Nations in the framework of its Children and Armed Conflict (CAAC
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2ieme edtion. Cette deuxième édition s'appuie sur l'expérience de plus de 10 ans de déploiement de la CPS et reflète les changements introduits dans les lignes directrices de l'OMS pour le paludisme, le 3 juin 2022. L'objectif de cette publication est de partager ces bonnes pratiques afin d'am...liorer la mise en œuvre, la couverture, le suivi et l'évaluation de la CPS. Des exemples de supports et d'outils ainsi que des liens vers des ressources sont inclus pour soutenir les responsables et les agents de santé dans leurs efforts pour mener à bien les activités de CPS et prévenir le paludisme chez les enfants vulnérables.
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Front. Malar. 3:1336324. doi: 10.3389/fmala.2025.1336324
It was a difficult time to be a child in 2024. With deepening violent conflict, climate shocks and poverty, children faced skyrocketing needs while the resources to respond continued to shrink.
But as this year’s Annual Report shows, across more than 190 countries and territories, UNICEF was t...here, saving and uplifting the lives of millions of children – even in the hardest-to-reach places. Together with our partners, we delivered clean water and sanitation, protection and psychosocial support, health, nutrition, and immunization services, and education and skills development.
The world in 2025 continues to be one of significant political shifts and volatility, economic uncertainty and deepening humanitarian crises. To succeed, UNICEF must be at its best.
But announced and anticipated funding cuts are limiting UNICEF’s ability to reach millions of children in dire need. These new cuts are creating a global funding crisis that will put the lives of millions of additional children at risk.
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This malaria education poster by Children for Health uses clear, child-friendly language to raise awareness of malaria and promote its prevention. Using simple language and engaging visuals, it informs children and caregivers about key facts, symptoms and protective behaviours, such as using insecti...cide-treated nets and seeking timely treatment. Designed for use in schools and communities, the poster supports health education initiatives aimed at reducing the impact of malaria in endemic regions by encouraging children to play an active role in preventing the disease.
Accessed on 20/06/2025.
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This document by Medicines for Malaria Venture (MMV) highlights the significant burden of malaria on children worldwide, emphasizing the need for effective prevention, diagnosis, and treatment strategies. It reviews current challenges and progress in combating pediatric malaria, advocating for conti...nued research and investment to reduce malaria-related morbidity and mortality in children, especially in high-burden regions.
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Lancet Glob Health 2020 Published Online October 22, 2020 https://doi.org/10.1016/S2214-109X(20)30325-9
Where malaria transmission is seasonal, notably in Africa’s Sahel region, children of all ages most at risk of severe malaria are protected through SMC. This intervention consists of full antimalarial treatment courses of sulfadoxine-pyrimethamine and amodiaquine (SPAQ), administered monthly (28 d...ays) during the high-transmission period (typically the rainy season), generally for up to five months per year. SMC can be deployed relatively easily across a large population and is highly cost-effective at only USD $0.30-0.40/dose,3 making it an important tool for malaria control
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WHO has updated it recommendations for 3 key malaria prevention strategies: seasonal malaria chemoprevention (SMC), perennial malaria chemoprevention (PMC – previously known as intermittent preventive treatment in infants, or IPTi) and intermittent preventive treatment of malaria in pregnancy (IPT...p). When given to the young children and pregnant women who are most vulnerable to malaria, preventive chemotherapy has been shown to be a safe, effective and cost-effective strategy for reducing the disease burden and saving lives.
The updated recommendations on SMC, PMC and IPTp, published today in the WHO Guidelines for malaria, will support the broader use of chemoprevention among young children at high risk of severe malaria in areas with both seasonal and year-round transmission and promote expanded access to preventive chemotherapy in pregnancy.
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Lancet 2024; 403: 533–44
R21/Matrix-M was well tolerated and offered high efficacy against clinical malaria in African children. This
low-cost, high-efficacy vaccine is already licensed by several African countries, and recently received a WHO policy
recommendation and prequalification, offerin...g large-scale supply to help reduce the great burden of malaria in sub-
Saharan Africa.
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Fragile Beginnings. The Fragile Beginnings series examines the growing body of research on the unique vulnerabilities of children: in utero and at birth, during infancy and childhood and throughout adolescence. Its purpose is to enable evidence-based advocacy and action on children’s environmental... health
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