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1
Publication Years
813
2555
295
10
3
Category
1578
202
140
122
104
103
23
2
Toolboxes
510
308
284
236
129
127
96
78
70
66
57
46
33
33
24
23
22
21
21
16
15
11
10
8
8
1
Int. J. Environ. Res. Public Health 2021, 18(5), 2477; https://doi.org/10.3390/ijerph18052477
Capacity Needs Assessment for Pharmaceutical Services for the ART Program in Lesotho
Wang, S., N. Hoohlo, I. Tshabalala, K. Ntoi, and T. Sepetla
Arlington, VA: Management Sciences for Health
(2013)
C2
Submitted to the US Agency for International Development by the Systems for Improved Access to Pharmaceuticals and Services (SIAPS) Program.
Chikungunya virus (CHIKV) is currently one of the most relevant arboviruses to public health. It is a member of the Togaviridae family and alphavirus genus and causes an arthritogenic disease known as chikungunya fever (CHIKF). It is characterized by a multifaceted disease, which is distinguished fr
...
om other arbovirus infections by the intense and debilitating arthralgia that can last for months or years in some individuals. Despite the great social and economic burden caused by CHIKV infection, there is no vaccine or specific antiviral drugs currently available. Recent outbreaks have shown a change in the severity profile of the disease in which atypical and severe manifestation lead to hundreds of deaths, reinforcing the necessity to understand the replication and pathogenesis processes. CHIKF is a complex disease resultant from the infection of a plethora of cell types. Although there are several in vivo models for studying CHIKV infection, none of them reproduces integrally the disease signature observed in humans, which is a challenge for vaccine and drug development. Therefore, understanding the potentials and limitations of the state-of-the-art experimental models is imperative to advance in the field. In this context, the present review outlines the present knowledge on CHIKV epidemiology, replication, pathogenesis, and immunity and also brings a critical perspective on the current in vitro and in vivo state-of-the-art experimental models of CHIKF.
more
Research Article
PLOS ONE | DOI:10.1371/journal.pone.0169530 February 16, 2017
Pathogens . 2021 Nov 16;10(11):1493.doi: 10.3390/pathogens10111493
.Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mech
...
anisms underlying Trypanosoma cruzi’s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particu-larly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.
more
National SOP document from Eswatini for community-based models for HIV testing and ART initiation. Contains specific procedural steps for testing and ART initiation in mobile/outreach contexts – v
...
ery practical for clinical SOP structures in similar settings.
more
Expert opinion of the European Tuberculosis Laboratory Initiative core group members for the WHO European Region.
Aлгоритм лабораторной диагностики и мониторинга лечения туберкулеза легких и туберкулеза с лекарственной устойчивостью на основе применения современных быстрых
...
молекулярных методов.
Экспертное заключение членов основной группы Европейской лабораторной инициативы, подготовленное для Европейского региона ВОЗ.
more
Thematic segment: Mental Health and HIV/AIDS – Promoting human rights, an integrated and person-centered approach to improving art adherence, well-being and quality of life
UNAIDS; STRIVE
(2018)
C2
1-13 December 2018 | Geneva, Switzerland UNAIDS Programme Coordinating Board Issue date: 23 November 2018
UNAIDS/PCB (43)/18.32
Web annex e. recommendations for use of hormonal contraception for women living with HIV using antiretroviral therapy (ART)
World Health Organization
(2018)
C_WHO
Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV: interim guidelines. Supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infe
...
ction
WHO/CDS/HIV/18.28
more
WHO’s sentinel surveys of acquired HIV resistance to dolutegravir among people receiving dolutegravir-containing antiretroviral therapy is intended for easy and frequent implementation. Results from sentinel surveys provide insight into the prevalence and year-over-year trends of dolutegravir resi
...
stance in adults, children and adolescents receiving dolutegravir-based ART.
This sentinel method is implemented complementary to WHO-recommended methods for estimating nationally representative levels of acquired HIV drug resistance.
more
