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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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WHO manual for HIV drug resistance testing using dried blood spot specimens

World Health Organization WHO (2020) C_WHO

HIV-1 drug resistance (HIVDR) genotyping is an essential component of the WHO global HIVDR surveillance strategy. Plasma “gold standard” specimen type for HIVDR genotyping, but its use may not be feasible in rural, remote areas in low- and middle-income countries, since preparing and storing it ... more

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Birth defects surveillance: a manual for programme managers

World Health Organization (2014)

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WHO country cooperation strategy 2014-2018, Myanmar

World Health Organization (WHO), Country Office for Myanmar (2014) C_WHO

The strategic priorities of the CCS 2014–2018 are:
(1) Strengthening the health system.
(2) Enhancing the achievement of communicable disease control targets.
(3) Controlling the growth of the noncommunicable disease burden.
(4) Promoting health throughout the life course.
... more

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Policy brief on tuberculosis-associated disability

World Health Organization WHO (2023) C_WHO

People affected by impairments and disabilities associated with TB are even more likely to belong to marginalized segments of society and are more likely to have their human rights unprotected. The challenges faced by people affected by TB include the consequences of impairment and disability associ... more

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Impact of health systems strengthening on coverage of maternal health services in Rwanda, 2000–2010: a systematic review

Maurice Bucagu, Jean M. Kagubare, Paulin Basinga, Fidèle Ngabo, Barbara K Timmons & Angela C Lee Reproductive Health Matters (2012) CC

From 2000 to 2010, Rwanda implemented comprehensive health sector reforms to strengthen the public health system, with the aim of reducing maternal and newborn deaths in line with Millennium Development Goal 5, among many other improvements in national health. Based on a systematic review of the lit... more

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Kenya Health Sector Strategic Plan 2018-2023

World Health Organisation (2018) C_WHO

Transforming Health Systems: Achieving Universal Health Coverage by 2022. The development of the Kenya Health Sector Strategic Plan 2018–2023 is guided by the Constitution of 2010, the Kenya Vision 2030 and the Kenya Health Policy 2014–2030.

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Problem Management Plus (PM+)
recommended

World Health Organization WHO (2016) C_WHO

Individual psychological help for adults impaired by distress in communities exposed to adversity. The manual describes a scalable psychological intervention called Problem Management Plus (PM+) for adults impaired by distress in communities who are exposed to adversity. Aspects of Cognitive Behavi... more

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Information and Communications Technology Response to the Liberia Ebola Crisis

USAID; Net Hope; GBI (2014)

Desk Review and Recommendations for Private Sector Engagement

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Analysing the response of a Teacher Training Institution to HIV and AIDS: A case study from Zambia

Lucinda Ramos UNESCO (2007) CC

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WHO implementation tool for pre-exposure prophylaxis of HIV infection - Module 9

World Health Organization (WHO) World Health Organization (WHO) (2017) C_WHO

Module 9 Strategic planning July 2017 Module 9: Strategic planning. As WHO recommends offering PrEP to people at substantial HIV risk, this module offers public health guidance for policy-makers on how to prioritize services, in order to reach those who could benefit most from PrEP, and in wh... more

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Toolkit on disability for AFRICA: FRAMEWORKS FOR IMPLEMENTING AND MONITORING THE UNITED NATIONS CONVENTION ON THE RIGHTS OF PERSONS WITH DISABILITIES

United Nations Division for Social Policy Development (DSPD) & United Nations Department of Economic and Social Affairs (DESA) (2016) C1

Module 2

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Severe acute respiratory infections treatment centre: practical manual to set up and manage a SARI treatment centre ( Arabic Version)

World Health Organization WHO (2020) C_WHO

آذار / مارس 2020مركز معالجة حالات العدوى التنفسیة الحادة الوخیمةدلیل عملي لإنشاء وإدارة مركز لمعالجة حالات العدوى التنفسیة الحادة الوخیمة وقسم لتحري المصابین بھذه ا�... more

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WHO Country Cooperation Strategy 2017-2021, Zambia

World Health Organization WHO, Regional Office for Africa (2017) C_WHO

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Invisible Wounds. The impact of six years of war on the mental health of Syria’s children

Save the Children (2017) C1

“The children are psychologically crushed and tired. When we do activities like singing with them, they don’t respond at all. They don’t laugh like they would normally. They draw images of children being butchered in the war, or tanks, or the siege and the lack of food.” Teacher in the... more

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WHO's Response to the Ukraine Crisis. Interim Report. February to June 2022

World Health Organization (WHO) (2022) C_WHO

The military offensive by the Russian Federation in Ukraine which began February 2022 has triggered one of the world’s fastest-growing displacement and humanitarian crisis, with geopolitical and economic ripples felt across the globe. The ongoing war has caused large-scale disruptions to the deliv... more

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Sierra Leone: Facility Improvement Team (FIT) Assessment Report, November 2015

Ministry of Health and Sanitation Sierra Leone, Reproductive and Child Health Directorate (2015) C1

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FACTI Panel Interim Report

The High-Level Panel on International Financial Accountability, Transparency and Integrity for Achieving the 2030 Agenda (FACTI Panel) The High-Level Panel on International Financial Accountability, Transparency and Integrity for Achieving the 2030 Agenda (FACTI Panel) (2020) CC

The High-Level Panel on International Financial Accountability, Transparency and Integrity for Achieving the 2030 Agenda (FACTI Panel) was convened by the 74th President of United Nations General Assembly and the 75th President of the Economic and Social Council on 2 March 2020. The objective of the... more

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Primary ear and hearing care training resource (ADVANCED LEVEL)

World Health Organization (WHO) (2006) C_WHO

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A practical handbook on the pharmacovigilance of antiretroviral medicines

World Health Organization WHO (2013) C_WHO

This is a detailed manual giving a step by step approach to undertaking the pharmacovigilance of antiretrovirals. It is intended to be a source of practical advice for Pharmacovigilance Centres and health professionals involved in HIV/AIDS prevention and treatment programmes. A number of WHO publica... more

Problem Management Plus (PM+) recommended

Problem Management Plus (PM+)
recommended