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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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orzsco-pack.org

The ORSZinc Co-pack Alliance (ORSZCA ) (2022) CC

This website was launched in January to advocate for the new WHO ORS/Zinc co-packaging recommendation (for diarrhoea treatment) and seek to remove barriers and exploit opportunities to the uptake of the recommendation in LMICs. As a part of this work we are establishing a knowledge base on the statu... more

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Nutritional interventions update: zinc supplements during pregnancy

World Health Organization WHO (2021) C_WHO

Evidence from a systematic review on antenatal zinc supplementation was evaluated as part of the World Health Organization (WHO) antenatal care (ANC) guideline development process in 2016, and the following recommendation on zinc supplementation was made: “Zinc supplementation for pregnant women i... more

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COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital

NICE guideline (2020) C2

This guideline is for: • health and care practitioners • health and care staff involved in planning and delivering services • commissioners. The recommendations bring together: • existing national and international guidance and policies • advice from specialists working in the NHS fr... more

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Hand hygiene for all initiative: improving access and behaviour in health care facilities

World Health Organization WHO (2020) C_WHO

The WHO and UNICEF-led Hand Hygiene for All Initiative aims at ensuring implementation for WHO's global recommendations on hand hygiene to prevent and control COVID-19 pandemic, and hand hygiene improvement sustainability in countries as a mainstay of wider infection prevention and control (IPC) and... more

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Executive summary: the selection and use of essential medicines 2021

World Health Organization WHO (2021) C_WHO

Report of the 23rd WHO Expert Committee on the selection and use of essential medicines This executive summary reports the recommendations made by the Expert Committee for the 2021 update of the WHO Model List of Essential Medicines (EML) and the Model List of Essential Medicine for Children (EMLc)... more

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Alcohol consumption and sustainable development: fact sheet on Sustainable Development Goals (‎SDGs)‎: health targets

World Health Organization WHO (2020) C_WHO

The Sustainable Development Goals (‎SDGs)‎ aim to transform our world. They are a call to action to end poverty and inequality, protect the planet, and ensure that all people enjoy health, justice and prosperity. It is critical that no one is left behind. In 2015, all the countries in the United... more

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Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups
recommended

A. Montresor World Health Organisation (WHO) (2017) C_WHO

Treating children infected with intestinal worms is one of the simplest and most cost–effective ways to improve their health. The recommendations are intended for a wide audience, including policy-makers and their expert advisers as well as technical and programme staff at government institution... more

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Assessment of infection prevention and control practices in isolation areas in acute healthcare settings in the context of the novel coronavirus (COVID-19)
recommended

Pan American Health Organization PAHO (2020) C_WHO

Infection prevention and control practices need to be implemented to guarantee the safety of healthcare workers and patients in healthcare settings, it is fundamental to prevent cross contamination and containment of spread of COVID 19. As of the day of this publication, the following precautions ar... more

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WHO consolidated guidelines on tuberculosis: module 4: treatment and care

World Health Organization WHO (2025) C_WHO

The Global Programme on Tuberculosis & Lung Health of the World Health Organization (WHO/GTB) is now combining all current recommendations into one overall set of consolidated guidelines on TB. The guidelines contain recommendations pertaining to all areas related to the programmatic management of T... more

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Microplanning Manual for Malaria Elimination in the Region of the Americas. Version for field personnel

World Health Organisation (WHO) (2024) C_WHO

The purpose of this manual is to provide guidance on how to implement Pan American Health Organization (PAHO) recommendations for malaria elimination at the local level. It is a streamlined, more operational version of the Manual for Stratifying Malaria Risk and Elimination of Foci, aimed primarily ... more

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Practical manual on tuberculosis laboratory strengthening, 2022 update

World Health Organisation (WHO) (2023) C_WHO

The Practical manual on laboratory strengthening, 2022 update provides practical guidance on implementation of WHO recommendations and best practices for TB laboratory strengthening. It is an updated version of the GLI Practical Guide to Laboratory Strengthening published in 2017 and provides the la... more

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Vaccine Hesitancy and COVID-19: Considerations for Communication

Limaya, R.J. International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health (2021) C1

This presentation presents the issues we confront in deciding how to communicate to the public that COVID-19 vaccine recommendations reflect the state of scientific knowledge.

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COVID-19 clinical care pathway (‎CARE)‎: confirm SARS-CoV-2 infection, assess symptoms, risk factors and severity, respond with appropriate care and treatment, evaluate clinical response and recovery

World Health Organization WHO (2022) CC

The COVID-19 CARE pathway is a living tool to support health care workers visualize the current clinical and therapeutic recommendations to be considered in the care planning for patients with COVID-19. The COVID-19 CARE pathway is aligned with the eighth version of the WHO Therapeutics and COVID... more

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Sustainable financing: feasibility of a replenishment mechanism, including options for consideration - Report by the Director-General

World Health Organization (WHO) World Health Organization (WHO) (2022) CC

The Seventy-fifth World Health Assembly through a decision on sustainable financing, adopted the recommendations of the Member States Working Group on Sustainable Financing, contained in Appendix 2 of the Working Group’s report to the Seventy-fifth World Health Assembly. As part of the recommendat... more

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Infection Control Assessment Tool: A Standardized Approach for Improving Hospital Infection Control Practices

South Africa's Dept. of Health; USAID; SIAPS (2010) C1

The ICAT is a simple and practical approach for assessing the adequacy of existing infection prevention and control practices and provides specific recommendations for improving practices and monitoring their effectiveness over time

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Not all that bleeds is Ebola
recommended

International Rescue Committee (2020) C1

How has the DRC Ebola outbreak impacted Sexual and Reproductive Health in North-Kivu? Recommendations (more specifics found in the assessment): 1. Sexual and reproductive health needs and services are to be embedded in the EVD response from the outset. 2. Reduce delays at every stage of the patie... more

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HIV Transmission and AIDS risk - Short brochure (English)

Bundeszentrale für gesundheitliche Aufklärung (BZgA) (2014) C2

Different situations, risks, recommendations. Short brochure with pictograms. Available in: English, Turkish, French, Russian at: http://www.bzga.de/infomaterialien/fremdsprachige-materialien/ AND German at: http://www.bzga.de/infomaterialien/aidsaufklärung/hiv-übertragung-und-aids-gefahr/

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COVID-19: Guidelines for case-finding, diagnosis, management and public health response in South Africa
recommended

Bham A., J. Bhiman, F. Bongweni et al. Centre for Respiratory Diseases and Meningitis and Outbreak Response (2020) C2

The information contained in this document, be it guidelines, recommendations, diagnostic algorithms or treatment regimens, are offered in this document in the public interest. To the best of the knowledge of the guideline writing team, the information contained in these guidelines is correct. Imple... more

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WHO Interim Guidance for Ebola Event Management at Points of Entry

World Health Organization WHO (2014)

The aim is to provide early detection of potentially infected persons; to assist in implementing WHO recommendations related to Ebola management; and to prevent the international spread of the disease while allowing PoE authorities to avoid unnecessary restrictions and delays

Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups recommended

Assessment of infection prevention and control practices in isolation areas in acute healthcare settings in the context of the novel coronavirus (COVID-19) recommended

Not all that bleeds is Ebola recommended

COVID-19: Guidelines for case-finding, diagnosis, management and public health response in South Africa recommended

Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups
recommended

Assessment of infection prevention and control practices in isolation areas in acute healthcare settings in the context of the novel coronavirus (COVID-19)
recommended

Not all that bleeds is Ebola
recommended

COVID-19: Guidelines for case-finding, diagnosis, management and public health response in South Africa
recommended