After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge...s of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC50 of around 1 µM against Trypanosoma brucei and is more than 100-fold less toxic to mammalian cells. In the mouse model, fexinidazole cures both the first, haemolymphatic, and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in the Democratic Republic of the Congo demonstrated that oral fexinidazole is safe and effective for use against first- and early second-stage sleeping sickness. Based on the positive opinion issued by the European Medicines Agency in 2018, the WHO has released new interim guidelines for the treatment of HAT including fexinidazole as the new therapy for first-stage and non-severe second-stage sleeping sickness caused by Trypanosoma brucei gambiense (gHAT). This greatly facilitates the diagnosis and treatment algorithm for gHAT, increasing the attainable coverage and paving the way towards the envisaged goal of zero transmission by 2030.
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Сотрудники структурного подразделения Московского института психоанализа "Виртуальная Клиника", а также группа специалистов Московского государственного униве...ситета им М.В. Ломоносова и Московского научно-практического центра наркологии Департамента здравоохранения Москвы запустили Программу дистанционных волонтерских групп взаимопомощи населению в период самоизоляции и режима повышенной готовности.
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Chagas disease, or American trypanosomiasis, is a condition that causes gradual organ damage. Without treatment, it can be fatal.
This article explains where the T. cruzi parasite is most common and how it can spread. It also outlines the symptoms of Chagas disease and the treatment options avail...able.
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A resource for the continued implementation of the Consolidated Action Plan to Prevent and Combat Multidrug- and Extensively
Drug-Resistant Tuberculosis in the WHO European Region 2011-2015
Please download the whole Document (large size 28 MB) directly from the website
Eurosurveillance is a European peer-reviewed scientific journal devoted to the epidemiology, surveillance, prevention and control of communicable diseases, with a focus on such topics that are of relevance to Europe
Способы, которые могут помочь вам предотвратить распространение коронавирусной инфекции COVID-19 при совместном пользовании автомобилем
Carpoooling and COVID-19
Human African trypanosomiasis (HAT) is a lethal neglected tropical disease (NTD) transmitted by the bite of infected tsetse flies. The disease is also known as “sleeping sickness”. During the 20th century it caused enormous suffering in the endemic areas in sub-Saharan Africa. HAT transmission l...ast soared in the late 1990s, triggering a renewed, coordinated and very successful control effort. In this paper, we present achievements towards HAT elimination, with a focus on the WHO road map targets for 2020. In particular, reported cases continue to decline, from over 30,000 cases per year at the turn of the century to 663 cases in 2020. Despite the impact of the COVID-19 pandemic, HAT surveillance was largely sustained, and the network of health facilities able to diagnose and treat the disease further expanded. Looking to the future, the World Health Organization (WHO) set bold new targets for HAT in its 2021–2030 road map for NTDs, namely: the elimination of transmission of gambiense HAT, which occurs in western and central Africa, and the elimination as a public health problem of rhodesiense HAT, which is found in eastern and southern Africa. The strong commitment of national health authorities and the international community will be essential if these goals are to be achieved.
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Правила безопасного ношения медицинских масок: что следует делать и чего не следуе
Инфографика
Additional aims of the consultations included discussing achievements, identifying obstacles for implementation, and outlining the way forward. Areas with the lowest policy implementation were linked to pricing policies, marketing, availability of alcoholic beverages, reducing the negative consequen...ces of drinking and alcohol intoxication and alcohol labelling. Conclusions highlight the need for a roadmap to strengthen policy areas with lower levels of implementation in order to guide Member States towards implementation.
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-Профилактика COVID-19
-Профилактика распространения
в медицинских организациях
-Мероприятия по профилактике
у медицинских работников
-Дезинфекционные мероприят...я
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Website last accessed on 22.05.2023
Leishmaniasis refers to a diverse group of diseases caused by single-celled parasites called Leishmania. About 12 million people are infected at any one time, causing up to 40,000 deaths annually.
The VALIDATE Network - Vaccine development for complex intra...cellular neglected pathogens
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Данная информация для пациентов основана на последних научных разработках. Она обобщает важнейшие пункты рекомендаций для пациентов на тему "Болезнь Паркинсона".
инфорграфика: Уход на дому за больными с заболеванием COVID-19
Taking care of sick people with COVID-19 at home
Если вы заболели COVID-19 или думаете, что у вас может быть
COVID-19, выполняйте указанные далее действия, чтобы
позаботиться о себе и защитить других людей в вашем
доме и ...обществе.
sick with COVID-19: fact sheet
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COVID-19 и права меньшинств: обзор и перспективные практики
COVID-19 and minority rights: overview and perspective practices
Правила безопасного ношения немедицинских тканевых масок: что нужно делать, а что нет.
Инфографика
Мы работаем для того, чтобы все пациенты в Европе, пострадавшие от инсульта, имелиправо на постоянный уход. От профилактики иидентификации рисков, через неотложную...помощь к организации подразделенийреагирования на инсульт в острой форме, кнадлежащей реабилитации и мероприятиямвторичной профилактики к 2015 г.
Accessed on 2019
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