In the past week, from 16 to 22 September, 39 new confirmed Ebola virus disease (EVD) cases, with an additional 22 deaths, have been reported from nine health zones in three affected provinces in the Democratic Republic of the Congo. Pockets of insecurity in the affected areas, along with localised security incidents, continue to hinder response activities, including safe and dignified burials (SDB), vaccination, contact tracing and case reporting. For instance, a recent major security incident in Lwemba, within Mandima health zone is still preventing response activities in this area. Overall, these incidents underscore the need for continued and proactive engagement and sensitizing of local communities, especially in the high risk areas that may not currently be affected. In the 21 days from 2 to 22 September 2019, 45 health areas in 13 health zones reported new cases (Table 1, Figure 2). During this period, a total of 129 confirmed cases were reported, with the majority coming from the health zones of Mambasa (25%, n=32 cases), Mandima (19%, n=25 cases), Kalunguta (17%, n=22 cases) and Beni (11%, n=14 cases).