This document aims to provide a risk assessment and management options for the safe and sustainable supply of substances of human origin (SoHO) to assist the European Union and European Economic Area (EU/EEA) Member States in responding to the threat posed by the coronavirus disease 2019 (COVID-19) pandemic. Following the rapid spread of COVID-19 in the EU/EEA and worldwide, the European Centre for Disease Prevention and Control (ECDC) has published a set of rapid risk assessments and set out measures on how to maintain the safety and sustainability of SoHO supply. It has also been advocating for EU/EEA Member States to activate pandemic plans to prepare for large outbreaks and community transmission of COVID-19.