Antidepressant medication in comparison with psychological treatment for moderate-severe depressive disorder

Depressive disorder is a highly prevalent and disabling disorder. Its relative disease burden is pronounced in high- and middle-income countries and it is also a major cause of disease burden in low-income countries. It is associated with reduced quality of life, impaired social and personal relationships, disturbed academic and professional life, a variety of physical health problems and elevated economic costs with individual and societal impacts