The HIV Clinical Guide provides guidelines and decision-support for healthcare workers treating HIV patients in South Africa. The app is for all categories of healthcare professionals, healthcare workers, managers of the national health laboratory services, programme managers at district, provincial and national level and community-based organisations working with people living with HIV. These guidelines address clinical and programmatic aspects of HIV treatment and prevention amongst pregnant and breastfeeding women, children, adolescents and adults by making use of the continuum of care, from HIV testing and counselling, linkage with care and treatment, general HIV care and all aspects of ART management.