This article was published on December 10, 2020, and updated on December 16, 2020, at NEJM.org. DOI: 10.1056/NEJMoa2034577
Patients with diabetes are at increased risk of developing cardiovascular disease (CVD) with its manifestations of coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF), and stroke, as well as aortic and peripheral artery diseases. In addition, diabetes is a major risk factor f...or developing chronic kidney disease (CKD), which in itself is associated with developing CVD. The combination of diabetes with these cardio-renal comorbidities enhances the risk not only for cardiovascular (CV) events but also for CV and all-cause mortality. The current European Society of Cardiology (ESC) Guidelines on the management of cardiovascular disease in patients with diabetes are designed to guide prevention and management of the manifestations of CVD in patients with diabetes based on data published until end of January 2023. Over the last decade, the results of various large cardiovascular outcome trials (CVOTs) in patients with diabetes at high CV risk with novel glucose- lowering agents, such as sodium–glucose co-transporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists (RAs), but also novel non-steroidal mineralocorticoid receptor antagonists (MRAs), such as finerenone have substantially expanded available therapeutic op-
tions, leading to numerous evidence-based recommendations for the management of this patient population.
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Clinical Infectious Diseases 2010; 50:291–322
Version 2 (unedited). The Basic Needs Analysis (BNA) is a multi-sector needs analysis approach that can be applied in both sudden onset and protracted emergencies. The methodology comprises the Guidance (this document) presenting the conceptual BNA framework and related processes, and a Toolbox, whi...ch includes tools, templates, training materials, and examples drawn from its first pilot, in Borno State(Nigeria).
The BNA is conceived to go hand in hand with the Facilitator’s Guide for the Response Options Analysis and Planning (a separate document), as it is part of a broader response planning process (see The BNA within the ). It shall be carried out with other assessments on the operational environment and would not add any value if undertaken in isolation.
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299 deaths have been recorded and 329 people are still missing, according to the Government.
• Latest assessments indicate that the homes of some tens of thousands of people have been destroyed or damaged beyond habitability. Most of these people are staying with hosts in the extended community.
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• Revised Flash Appeal requires US$294 million to respond to the drought and Cyclone Idai.
• Food Cluster partners have so far assisted an estimated 30,000 people in the worst-affected areas of Chimanimani and Chipinge.
• Access to a sufficient quantity of water for drinking, cooking and personal hygiene has been restored for 43,000 people.
• Eight clusters have been activated to bolster the humanitarian response effort in support to the Government of Zimbabwe,
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Letter of the holy father
This progress report reviews recent gains, new developments and remaining challenges as countries approach the 2020 targets of the Start Free Stay Free AIDS Free framework.
MEDBOX Issue Brief no. 19: World TB Day: Invest to end TB. Save Lives
MMC Briefing Paper, February 2021
Objetivo: Describir el perfil de sensibilidad y resistencia antimicrobiana de las bacterias “ESKAPE” aisladas en todas las unidades de internación del Hospital Del Norte durante la gestión 2019.
The Creditor Reporting System was analysed for official development assistance funding disbursements towards TB control in 11 conflict-affectedstates, 17 non-conflict-affected fragile states and 38 comparable non-fragile states. The amounts of funding, funding relative to burden, funding relative to... malaria and human immunodeficiency virus (HIV) control, disbursements relative to commitments, sources of funding as well as funding activities were extracted and analysed.
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The Call to Action on Protection from GBV in Emergencies, formally launched in 2013 by the United Kingdom and Sweden, aims to fundamentally transform the way GBV is addressed in humanitarian operations via the collective action of numerous partners, each bringing our various strengths and capacities... to the table. Our goal is to drive change and foster accountability within the humanitarian sphere. The commitment to act and to hold ourselves accountable for action is what binds us together under the Call to Action.
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Strengthening resilient agricultural livelihoods
Level 3 responses are activated in the most complex and challenging humanitarian emergencies, when the highest level of mobilization is required across the humanitarian system. Even before the conflict escalated, the country suffered high levels of p...overty, food insecurity, undernutrition and malnutrition, water shortages and land degradation. Yemenis are also facing armed conflict, displacement, risk of famine and disease outbreaks.
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