N Engl J Med 2022; 386:911-922, DOI: 10.1056/NEJMoa2104535
Four months of antituberculosis treatment was noninferior to 6 months of treatment in children with drug-susceptible, nonsevere, smear-negative tuberculosis (SHINE Study)
                                                            
                         
                     
                                                        
                        
                        
                            
                            
                                                                Frontiers in Pediatrics | www.frontiersin.org
1 April 2019 | Volume 7 | Article 159
                                                            
                         
                     
                                                        
                        
                        
                            
                            
                                                                MEDBOX Issue Brief no. 19: World TB Day: Invest to end TB. Save Lives
                                                            
                         
                     
                                                        
                        
                        
                            
                            
                                                                The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatment of TB meningitis, the use of bedaquiline and delama...nid in young children with multidrug- and rifampicin-resistant TB and decentralized and family-centred, integrated models of care for TB case detection and prevention in children and adolescents.
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                                                                The results of the SHINE trial have been published in the NEJM today. SHINE looked at whether treatment for children with minimal TB could be reduced from 6 months to 4 months. It found that the four month treatment was as good as the standard six months treatment for children with minimal TB