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Investment Case - Eighth Replenishment 2025 - Executive Summary

The Global Fund (2025) CC

To deliver on the Global Fund Strategy milestones for 2028 and ensure we keep the SDG 3 target within reach, we need to raise US$18 billion to fund the Global Fund’s next three-year grant cycle.

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Investment Case - At a glance - Eighth Replenishment 2025

The Global Fund (2025) CC

This is a moment of reckoning in the fight against HIV, tuberculosis (TB) and malaria. For our Eighth Replenishment, the Global Fund needs US$18 billion to save 23 million lives, cut the death rate from the three diseases by 64% and help build a healthier, safer and more equitable world.

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The future of health in Mozambique: Collaborative efforts for sustainable financing

N’weti, Wemos (2024) CC

As part of the project ‘Equitable health financing for a strong health system in Mozambique’, N’weti and Wemos developed this policy brief with actionable policy recommendations for the Mozambican government and international organizations on how to increase resources for health in a sustainab... more

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Declaration by African Youth to End Malaria in Africa by 2030

RBM Partnership to End Malaria (2023) C2

The Declaration by African Youth to End Malaria in Africa by 2030 is a commitment from young people across Africa to eradicate malaria by the year 2030. In this document, they outline specific strategies and actions they pledge to undertake, emphasizing the importance of youth involvement in mala... more

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Africa’s Health Financing in a New Era

Africa Centres for Disease Control and Prevention (Africa CDC) (2025) CC

Africa’s health sector is facing an unprecedented financing crisis, driven by a sharp decline of 70% in Official Development Assistance (ODA) from 2021 to 2025 and deep-rooted structural vulnerabilities. This collapse is placing immense pressure on Africa’s already fragile health systems as ODA ...is seen as the backbone of critical health programs: pandemic preparedness, maternal and child health services, disease control programs are all at risk, threatening Sustainable Development Goal 3 and Universal Health Coverage. Compounding this is Africa’s spiraling debt, with countries expected to service USD 81 billion by 2025—surpassing anticipated external financing inflows—further eroding fiscal space for health investments. Level of domestic resources is low. TThe Abuja Declaration of 2001, a pivotal commitment made by African Union (AU) member states, aimed to reverse this trend by pledging to allocate at least 15% of national budgets to the health sector. However, more than two decades later, only three countries—Rwanda, Botswana, and Cabo Verde—have consistently met or exceeded this target (WHO, 2023). In contrast, over 30 AU member states remain well below the 10% benchmark, with some allocating as little as 5–7% of their national budgets to health. In addition, only 16 (29%) of African countries currently have updated versions of National Health Development Plan (NHDP) supported by a National Health Financing Plan (NHFP). These two documents play a critical role in driving internal resource mobilisation. At the same time, public health emergencies are surging, rising 41%—from 152 in 2022 to 213 in 2024—exposing severe under-resourcing of health infrastructure and workforce. Recurring outbreaks (Mpox, Ebola, cholera, measles, Marburg…) alongside effects of climate change and humanitarian crises in Eastern DRC, the Sahel, and Sudan, are overwhelming systems stretched by chronic underfunding. The situation is worsened by Africa’s heavy dependency with over 90% of vaccines, medicines, and diagnostics being externally sourced—leaving countries vulnerable to global supply chain shocks. Health worker shortages persist, with only 2.3 professionals per 1,000 people (below the WHO’s recommended 4.45), and fewer than 30% of systems are digitized, undermining disease surveillance and early warning. Without decisive action, Africa CDC projects the continent could reverse two decades of health progress, face 2 to 4 million additional preventable deaths annually, and a heightened risk of a pandemic emerging from within. Furthermore, 39 million more Africans could be pushed into poverty by 2030 due to intertwined health and economic shocks. This is not just a sectoral crisis—it is an existential threat to Africa’s political, social, and economic resilience, and global stability. In response, African leaders, under Africa CDC’s stewardship, are advancing a comprehensive three-pillar strategy centered on domestic resource mobilization, innovative financing, and blended finance. more

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National Strategic Plan: Malaria Elimination 2023-27

National Centre for Vector Borne Disease Control (NCVBDC) Ministry of Health and Family Welfare (MoHFW) - India (2023) C2

The National Strategic Plan for Malaria Elimination in India (2023-2027) focuses on achieving malaria elimination by 2030, in alignment with the Global Technical Strategy. The document outlines the strategies, targets, and goals for malaria elimination, aiming for zero indigenous malaria cases by 20... more

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Together, we can build a Malawi where girls are free

UNICEF (2021) C_UNICEF

Concerned that the prevalence of Child Marriage in Malawi, at 42 per cent, is one of the highest in the Sub-Saharan Africa; and that cases of child marriage continue to rise despite the various interventions on the ground. If unabated, Child Marriage inflicts significant socio-economic and political... more

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Theory of Change

Nutrition and Food Security Alliance of Namibia; UNFPA; UNICEF; et al. (2020) CC2

Early Identification and Early Intervention Services for Young Children with Developmental Delays and Disabilities in Namibia Republic of Namibia Namibia Regional Consultations Report

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Regional Child Protection Operational Note

International Organization for Migration (IOM) (2025) C2

The Regional Child Protection Operational Note has been developed by IOM and UNICEF’s Regional and Country Offices in North, West and Central Africa as a collaborative inter-agency and cross-regional endeavour within the framework of the sixth phase of the IOM Regional Development and Protection P... more

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Denial of Humanitarian Access to Children: A Guidance Note for the Children and Armed Conflict Agenda

UNICEF; UN Office of the SRSG for Children and Armed Conflict Reliefweb OCHA (2025) C_UNICEF

ith a view to support the monitoring and reporting on the denial of humanitarian access against children, the Office of the Special Representative of the Secretary-General for Children and Armed Conflict and UNICEF publish today* a guidance note offering new tools to practitioners to better address ... more

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Drugs for Intermittent Preventive Treatment of Malaria in Pregnancy: Current Knowledge and Way Forward

Figueroa-Romero, A.; C. Pons-Duran, and R. Gonzalez (2022) CC

Trop. Med. Infect. Dis. 2022, 7, 152. https://doi.org/10.3390/tropicalmed7080152

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Strategic Malaria Communication Guide for Central America 2015-2020

Amazon Malaria Initiative AMI (2015) CC

The Strategic Malaria Communication Guide for Central America is intended to facilitate the shift from malaria control to elimination by strengthening communication and advocacy initiatives throughout the region. Based on interviews and a review of literature, the guide offers National Malaria Progr... more

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Lil Mosquito, Big Problem Campaign: Phase II

Breakthrough ACTION Guyana; Ministry of Health of Guyana (2025) C1

In 2023, Breakthrough ACTION and Guyana’s Ministry of Health refined the 'Lil Mosquito, Big Problem' malaria campaign using human-centred design. Phase II introduced peer-led videos (Miners' Buzz), community champions, incentives for volunteer testers and a transport network to improve supply deli... more

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Malaria: 10 messages for children to learn and share

Children for Health (2018) C1

This malaria education poster by Children for Health uses clear, child-friendly language to raise awareness of malaria and promote its prevention. Using simple language and engaging visuals, it informs children and caregivers about key facts, symptoms and protective behaviours, such as using insecti... more

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WASH Cluster Compendium of Solid Waste Management (SWM) in Humanitarian Contexts

UN Children's Fund UNICEF; WASH Cluster (2025) CC

The Compendium of Solid Waste Management in Humanitarian Contexts is a comprehensive, structured and userfriendly manual and planning guide that provides a systematic overview of existing Solid Waste Management (SWM) technologies and approaches appropriate for use in humanitarian contexts.

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Community early warning systems: guiding principles

International Federation of Red Cross IFRC (2020) C1

This guide aims to provide an overview of successful practice from the field for the disaster risk reduction/management practitioner interested in EWS. It presents guiding principles that will build a strong foundation for the design or strengthening of EWS at any level. It is not an operational, bu... more

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Nursing Guide for Managing Side Effectsto Drug-resistant TB Treatment

Raftery A, Tudor C, True L, Navarro C (2018) C1

The guide is organized into the major types of toxicities, the associated symp-toms, possible offending medications, and the suggested nursing assessments and interventions. Some symptoms (e.g. nausea) may be associated with a num-ber of underlying causes and may be mild, or a symptom of... more

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Addressing the Needs of the Most Vulnerable Communities through Identification and Selection of at-risk Project Sites

Myanmar Red Cross Society (2011) C1

CBDRR Practice. Case Studies 1
No publication year indicated.

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Improving Prison Conditions by Strengthening the Monitoring of HIV, HCV, TB and Harm Reduction (Latvia)

A. Kamensa, S. Olsena Latvian Centre for Human Rights; European Union (2016) C2

Mapping Report - Latvia.

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Поддержание бесперебойных поставок донорской крови в необходимом объеме в период пандемической вспышки коронавирусной инфекции (COVID-19)

Всемирная организация здравоохранения (ВОЗ) (2020) C_WHO

Временные рекомендации 20 марта 2020 г. В этом документе представлены временные рекомендации, касающиеся управления поставками донорской крови в рамках ответных �... more