Chagas heart disease (CHD) affects approximately 30% of patients chronically infected with the protozoa Trypanosoma cruzi. CHD is classified into four stages of increasing severity according to electrocardiographic, echocardiographic, and clinical criteria. CHD presents with a myriad of clinical man...ifestations, but its main complications are sudden cardiac death, heart failure, and stroke. Importantly, CHD has a higher incidence of sudden cardiac death and stroke than most other cardiopathies, and patients with CHD complicated by heart failure have a higher mortality than patients with heart failure caused by other etiologies. Among patients with CHD, approximately 90% of deaths can be attributed to complications of Chagas disease. Sudden cardiac death is the most common cause of death (55%-60%), followed by heart failure (25%-30%) and stroke (10%-15%). The high morbimortality and the unique characteristics of CHD demand an individualized approach according to the stage of the disease and associated complications the patient presents with. Therefore, the management of CHD is challenging, and in this review, we present the most updated available data to help clinicians and cardiologists in the care of these patients. We describe the clinical manifestations, diagnosis and classification criteria, risk stratification, and approach to the different clinical aspects of CHD using diagnostic tools and pharmacological and non-pharmacological treatments.
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Vitamin A deficiency is a risk factor for blindness and for mortality from measles and diarrhoea in children aged 6–59 months. We aimed to estimate trends in the prevalence of vitamin A defi ciency between 1991 and 2013 and its mortality burden in low-income and middle-income countries.
WHO and UNITAID
in collaboration with IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials) network, PENTA (Paediatric European Network for Treatment of AIDS) foundation and experts from the Paediatric Antiretroviral Working Group
Ce manuel donne une vue d’ensemble des connaissances scientifiques actuelles sur l’infection à VIH ainsi que des technologies et des outils utilisés pour prévenir cette infection, pour améliorer la qualité de vie des personnes infectées et pour réduire les effets du VIH sur les enfants et... leur famille. Le manuel présente aussi les stratégies nécessaires pour atteindre les personnes ayant besoin de ces interventions et définit leurs normes.
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Пандемия COVID-19 вызвала кризис системы здравоохранения и социальноэкономический кризис глобального масштаба. В связи с ограничениями на
поездки и передвижение гр...жданское общество и гуманитарные организации
играют важнейшую роль в оказании поддержки правительствам при
проведении ими ответных мероприятий. Все люди должны быть защищены от
сексуальной эксплуатации и сексуальных надругательств при получении
гуманитарной помощи, включающей медицинское обслуживание и лечение, а
также от жестокого обращения и эксплуатации. Если сексуальная
эксплуатация или сексуальные надругательства имеют место, люди должны
иметь доступ к безопасным и конфиденциальным услугам и каналам
информирования. Guidance on COVID-19 - Protection from Sexual Exploitation and Abuse
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IAEA Safety Standards for protecting people and the environment
The Anglophone Africa Civil Society and Communities CCM Shadow Report and Scorecard Initiative
Development assistance for health (DAH) has increased substantially in recent years and is seen as important to the improvement of health and health systems in developing countries. As a result, there has been increasing interest in tracking and understanding these resource flows from the global hea...lth community. A number of datasets, each with its own strengths and weaknesses, are available to track DAH. In this article we review the available datasets on DAH and summarize the strengths and weaknesses of each of these datasets to help researchers make the best choice of which to use to inform their analysis. Finally, we also provide recommendations about how each of these datasets could be improve
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Medicines and medical devices for 10 000 people for approximately three months
Global HIV Strategic Information Working Group
For Populations At Risk For HIV