Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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With Asthma Day coming up, Edrine Osteen Mukalazi sat down with Dr. Rebecca Nantanda to discuss "Closing the gap on #Asthma care for children on the Health Pot show."
Leave on a comment and let us know whether this video has been educational for you.
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✽ Our guest Rebecca Nantanda ✽
⊳ Dr. Rebecca Nantanda is a member of the Institute Technical Board (ITB) of Makerere University Lung Institute.
⊳ She has been involved in research on respiratory diseases in children for the past 12 years with specific focus on pneumonia and asthma.
⊳ She has a number of publications in peer-reviewed journals and has made several presentations at International and Local Scientific conferences on the above subjects.
⊳ She is currently involved in research, clinical care and pre-service and in-service training of health care professionals.
⊳ Her qualifications contain MBChB (MUST), M.Med Paediatrics and Child Health (MUK), PhD, Postdoctoral Research Fellow, Sida- Makerere Research Program.
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Although air pollution is well known to be harmful to the lung and airways, it can also damage most other organ systems of the body. It is estimated that about 500,000 lung cancer deaths and 1.6 million COPD deaths can be attributed to air pollution, but air pollution may also account for 19% of all... cardiovascular deaths and 21% of all stroke deaths. Air pollution has been linked to other malignancies, such as bladder cancer and childhood leukemia. Lung development in childhood is stymied with exposure to air pollutants, and poor lung development in children predicts lung impairment in adults. Air pollution is associated with reduced cognitive function and increased risk of dementia. Particulate matter in the air (particulate matter with an aerodynamic diameter < 2.5 μm) is associated with delayed psychomotor development and lower child intelligence. Studies link air pollution with diabetes mellitus prevalence, morbidity, and mortality. Pollution affects the immune system and is associated with allergic rhinitis, allergic sensitization, and autoimmunity. It is also associated with osteoporosis and bone fractures, conjunctivitis, dry eye disease, blepharitis, inflammatory bowel disease, increased intravascular coagulation, and decreased glomerular filtration rate. Atopic and urticarial skin disease, acne, and skin aging are linked to air pollution. Air pollution is controllable and, therefore, many of these adverse health effects can be prevented.
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Dieser Film ist ein Informationsfilm für Flüchtlinge in Deutschland. Es geht um die Anhörung beim Bundesamt für Migration und Flüchtlinge. Die Anhörung ist ein Gespräch während dem man seine Fluchtgeschichte erzählt. Es ist der zentrale Moment eines*r jeden Asylsuchenden. Denn danach wird ...entschieden, ob man als Flüchtling anerkannt wird, oder nicht. Du kannst das Video frei nutzen, teilen und jeder*m zeigen, dem es hilfreich sein könnte. Es steht dir in 14 Sprachen zur Verfügung. Weiterführende Links zu Beratungsstellen findest du auf der nächsten Seite. Der Film ersetzt keine ausführliche rechtliche Beratung und ist eine Erstinformation.
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Der Globale Fonds (GF) ist ein unverzichtbares Finanzierungsinstrument für die effektive Bekämpfung der drei großen Epidemien Aids, Tuberkulose und Malaria. Zu seinen Grundprinzipien gehören die Ausrichtung auf Wirksamkeit der Präventions- und Behandlungsprogramme, die Einbindung aller wichtige...n zivilgesellschaftlichen Akteure und Communitys, der Fokus auf die Umsetzung menschenrechtsbasierter Ansätze, Country Ownership sowie transparente Entscheidungsprozesse einschließlich der Mittelvergabe. 2019 sagte Deutschland für die 6. Wiederauffüllungskonferenz für den Zeitraum bis 2022 eine Milliarde Euro zu. 2020 kamen Sonderzahlungen in Höhe von 150 Mio € für den vom GF eingerichteten Covid-19-Krisenreaktionsmechanismus (Covid-19 RM) zur Eindämmung der Pandemie hinzu, in 2021 nochmals 140 Mio. €. Der Mehrbedarf zur Bewältigung der Covid-19 Pandemie ist jedoch unabhängig vom Bedarf für die Bekämpfung von Aids, Tuberkulose und Malaria zu betrachten. Dieser Mehrbedarf darf nicht über das Kernbudget für die Programme des Globalen Fonds gedeckt werden.
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WHO/CDS/TB/99.272
Distr.: General, Original: French
District Level M & E Training and Reference Material for Primary Health Care Programmes
District Level M & E Training and Reference Material for Primary Health Care Programmes
This document has been developed to support countries to develop and strengthen peer support groups in mental health and related areas. It addresses the provision of peer support groups in the context of health services and the wider community.
Oсобенности клинических проявлений и лечения заболевания, вызванного новой коронавирусной инфекцией (Covid-19) у детей (clinical guidelines pediatrics)
Lessons learned from an M&E task-shifting initiative in Botswana
Orientações para a vigilância em saúde, no que se refere aos aspectos epidemiológicos e laboratoriais da vigilância genômica da covid-19
I examine the effectiveness of donors in targeting the highest burden of malaria in the Democratic Republic of Congo when health information structure is fragmented. I exploit local variations in the burden of malaria induced by mining activities as well as financial and epidemiological data from he...alth facilities to estimate how local aid is matching local health needs. Using a regression discontinuity design, I find significant but quantitatively small variations in aid to health facilities located within mining areas. Comparing local aid with the additional cost of treatment and prevention associated with the increased risk of malaria transmission, I find suggestive evidence that local populations with the highest burden of the disease receive a proportionately lower share of aid compared to neighbouring areas with reduced exposure to malaria infection. The evidence of disparities in the allocation of aid for malaria supports the view that donors may have inaccurate information about local population needs.
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The biosphere underlies the whole sustainable development concept, as the layer on
which society and the economy rely. Nature and biodiversity fuel the natural cycles
and life-support systems of the planet, on which humanity ultimately depends.
The document "Diabetes and Ramadan: Practical Guidelines 2021," published by Elsevier, provides updated guidance for managing diabetes during Ramadan fasting. Developed by the International Diabetes Federation (IDF) and the Diabetes and Ramadan (DAR) International Alliance, the guidelines address ke...y aspects for individuals with diabetes who choose to fast, including risk assessment, blood glucose monitoring, insulin and medication adjustments, and the management of special populations (such as pregnant women, the elderly, and those with chronic conditions). Emphasis is placed on individualized patient education before Ramadan to ensure safe fasting practices and minimize risks like hypoglycemia and hyperglycemia.
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South Eastern European Journal of Public Health, EEJPH 2016, posted: 11 January 2016. DOI 10.4119/UNIBI/SEEJPH-2016-85