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Peripheral arterial disease (PAD) in the legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can happen in any blood vessel, but
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it is more common in the legs than the arms.
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Two decades of epidemiological research shows that silent cerebrovascular disease is common and is associated with future risk for stroke and dementia. It is the most common incidental finding on brain scans. To summarize evidence on the diagnosis and management of silent cerebrovascular disease to
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prevent stroke, the Stroke Council of the American Heart Association convened a writing committee to evaluate existing evidence, to discuss clinical considerations, and to offer suggestions for future research on stroke prevention in patients with 3 cardinal manifestations of silent cerebrovascular disease: silent brain infarcts, magnetic resonance imaging white matter hyperintensities of presumed vascular origin, and cerebral microbleeds. The writing committee found strong evidence that silent cerebrovascular disease is a common problem of aging and that silent brain infarcts and white matter hyperintensities are associated with future symptomatic stroke risk independently of other vascular risk factors. In patients with cerebral microbleeds, there was evidence of a modestly increased risk of symptomatic intracranial hemorrhage in patients treated with thrombolysis for acute ischemic stroke but little prospective evidence on the risk of symptomatic hemorrhage in patients on anticoagulation. There were no randomized controlled trials targeted specifically to participants with silent cerebrovascular disease to prevent stroke. Primary stroke prevention is indicated in patients with silent brain infarcts, white matter hyperintensities, or microbleeds. Adoption of standard terms and definitions for silent cerebrovascular disease, as provided by prior American Heart Association/American Stroke Association statements and by a consensus group, may facilitate diagnosis and communication of findings from radiologists to clinicians.
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This is an update (third edition) of the BACPR Standards & Core Components and represents current evidence-based best practice and a pragmatic overview of the structure and function of Cardiovascular Prevention and Rehabilitation Programmes (CPRPs) in the UK. The previously described seven standards
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have now been reduced to six but without sacrificing any of the key elements and with a greater emphasis placed on measurable clinical outcomes, audit and certification. Similarly, the second edition provided an overview of seven core components felt to be essential for the delivery of quality prevention and rehabilitation, and this too has been reduced to six. The interplay between cardio-protective therapies and medical risk factors is almost impossible to disentangle for the vast majority of patients and even if specific drug therapies are deployed exclusively for risk factor modulation, the indirect effect will also be cardio-protective. Thus, these have been combined into a single core component – medical risk management.
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Cardiovascular disease is a major cause of disability and premature death throughout the world, and contributes substantially to the escalating costs of health care. The underlying pathology is atherosclerosis, which develops over many years and is usually advanced by the time symptoms occur, genera
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lly in middle age. Acute coronary and cerebrovascular events frequently occur suddenly, and are often fatal before medical care can be given. Modification of risk factors has been shown to reduce mortality and morbidity in people with diagnosed or undiagnosed cardiovascular disease.
This publication provides guidance on reducing disability and premature deaths from coronary heart disease, cerebrovascular disease and peripheral vascular disease in people at high risk, who have not yet experienced a cardiovascular event. People with established cardiovascular disease are at very high risk of recurrent events and are not the subject of these guidelines. They have been addressed in previous WHO guidelines.
Several forms of therapy can prevent coronary, cerebral and peripheral vascular events. Decisions about whether to initiate specific preventive action, and with what degree of intensity, should be guided by estimation of the risk of any such vascular event. The risk prediction charts that accompany these guidelinesb allow treatment to be targeted accord-
ing to simple predictions of absolute cardiovascular risk.
Recommendations are made for management of major cardiovascular risk factors through changes in lifestyle and prophylactic drug therapies. The guidelines provide a framework for the development of national guidance on prevention of cardiovascular disease that takes into account the particular political, economic, social and medical circumstances.
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At the end of 2023, WHO convened our first-ever annual WHO Stakeholder Review Conference for Prevention and Response to Sexual Misconduct. Aimed at joint learning and frank discussion on challenges faced in the achieving zero tolerance for all forms of sexual misconduct by aid workers, the Conferenc
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e brought together Member States, Civil Society Organizations, United Nations Agencies and Programmes, academia and media joined by WHO personnel. A set of recommendations to support all agencies are documented in the Conference Report. In addition, WHO’s Director-General hosted a social engagement segment on the evening of Day 1 to further underscore the centrality of a victim and survivor-centred approach, to celebrate progress however small, and to reaffirm commitment and renew energy for the journey ahead. The Conference took place on 30 November and 1 December 2023 in Geneva, Switzerland
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MSF often responds to outbreaks of cholera in the countries we work. But how do we set up our cholera treatment centres to ensure our patients get the best care possible - and that the disease doesn't spread? Learn more about the layout and activities of an MSF cholera treatment centre in this inter
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active guide.
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Malawi's Ministry of Health officially declared on August 16, 2023, that the cholera outbreak is no longer a national health emergency. Since the outbreak began in February 2022, the country recorded 58,982 cholera cases and 1,768 deaths. Through coordinated efforts by the government, development pa
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rtners, and local communities, the outbreak has been contained in 26 out of 29 districts.
Only a few isolated cases remain in areas affected by Cyclone Freddy. The Minister of Health emphasized the importance of water, sanitation, and hygiene (WASH) initiatives to prevent future outbreaks. The World Health Organization (WHO) praised Malawi’s progress and pledged continued support to mitigate remaining risks.
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L'article "Témoignages de mères face au choléra" sur ReliefWeb présente les récits de mères haïtiennes dont les enfants ont été touchés par le choléra. Il met en lumière les défis auxquels ces familles sont confrontées, en particulier dans les régions où l'accès aux soins de santé
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et aux infrastructures sanitaires est insuffisant. L'article souligne la vulnérabilité accrue des enfants malnutris face au choléra et insiste sur l'importance des mesures de prévention ainsi que sur la nécessité d'un accès à l'eau potable et à des soins médicaux adéquats.
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Der RKI-Ratgeber zur Malaria bietet umfassende Informationen über die durch Plasmodium-Parasiten verursachte Infektionskrankheit. Er richtet sich an medizinisches Fachpersonal und den Öffentlichen Gesundheitsdienst und behandelt Themen wie Infektionswege, Symptomatik, Diagnostik, Therapie und Prä
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vention der Malaria. Zudem werden gesetzliche Grundlagen, Meldepflichten sowie Beratungs- und Spezialdiagnostikmöglichkeiten erläutert. Der Ratgeber wird regelmäßig aktualisiert, um den neuesten Stand der Wissenschaft und epidemiologischen Daten widerzuspiegeln.
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World malaria report 2024
recommended
New data from the WHO reveal that an estimated 2.2 billion cases of malaria and 12.7 million deaths have been averted since 2000, but the disease remains a serious global health threat, particularly in the WHO African Region. According to WHO’s latest World malaria report, there were an estimated
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263 million cases and 597 000 malaria deaths worldwide in 2023. This represents about 11 million more cases in 2023 compared to 2022, and nearly the same number of deaths. Approximately 95% of the deaths occurred in the WHO African Region, where many at risk still lack access to the services they need to prevent, detect and treat the disease.
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Pocket Manual for the Diagnosis and Treatment of Malaria
Olumese P., Al Zedjali M.S., Al-Mukhaini S.
Ministry of Health, Sultanate of Oman - Department of Malaria Eradication
(2025)
C2
The "Pocket Manual for the Diagnosis and Treatment of Malaria", published by the Ministry of Health of the Sultanate of Oman, provides practical guidance for healthcare professionals on how to identify, manage, and treat malaria cases. It emphasizes parasitological confirmation before treatment, out
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lines standard protocols for treating uncomplicated and severe malaria—including P. falciparum, P. vivax, and mixed infections—and specifies drug regimens based on patient weight and age. The manual also includes recommendations for travelers on malaria chemoprophylaxis and highlights the importance of prevention, especially for high-risk groups like children and pregnant women.
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Front. Malar. 3:1336324. doi: 10.3389/fmala.2025.1336324
Renforcement des capacités de lutte contre le paludisme : Guide du conseiller
HRH2030 (Human Resources for Health in 2030)
USAID (United States Agency for International Development)
(2021)
C2
Le document intitulé « Guide du conseiller – Renforcement des capacités de lutte contre le paludisme » est un guide pratique destiné aux conseillers techniques travaillant au sein des Programmes nationaux de lutte contre le paludisme (PNLP), principalement dans des pays partenaires souten
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us par l’USAID. Il a pour objectif de fournir des orientations concrètes sur la manière d’appuyer efficacement les PNLP dans la gestion, la planification stratégique, la mise en œuvre des subventions du Fonds mondial et le renforcement des capacités organisationnelles et humaines. Le guide décrit le rôle des conseillers, les étapes de leur intégration, les outils d’évaluation de performance, ainsi que les bonnes pratiques pour collaborer avec les partenaires locaux. Il met l’accent sur une approche participative, le transfert de compétences et la durabilité des interventions, dans une perspective d’amélioration continue des systèmes de santé.
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Dans certaines parties d’Afrique, la transmission du paludisme a lieu principalement pendant les trois ou quatre mois de la saison des pluies. Environ 39 millions d’enfants de moins de cinq ans vivent dans les zones de transmission saisonnière, où on dénombre environ 34 millions de cas et où
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plus de 150.000 enfants meurent chaque année. La CPS est une intervention préventive ciblant spécifiquement les enfants vivant dans ces régions. La CPS, appelée autrefois traitement préventif intermittent chez l’enfant, est « l’administration intermittente d’un traitement complet par un médicament antipaludique pendant la saison du paludisme afin de prévenir la
maladie, avec pour objectif de maintenir les concentrations sanguines du médicament antipaludique à des taux thérapeutiques pendant toute la période où le risque de paludisme est le plus élevé. »
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You can download the modules from the website
La surveillance, suivi et'évaluation (SSE) jouent un rôle vital dans tous les programmes de contrôle et de prévention du paludisme. Ce cours en ligne, offert par MEASURE Evaluation, fournit une introduction complète aux SSE des programmes de lutte contre le paludisme.
Téléchargez un PDF du c
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ours complet ou téléchargez les modules individuels ci-dessous. Pour accéder au cours en ligne de certification
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Em resposta aos primeiros casos de doença coronavírus de 2019 (COVID-19) notificados no continente, muitos Estados-Membros da União Africana implementaram rapidamente medidas sociais e de saúde pública em larga escala (PHSM). Estas medidas visavam reduzir a transmissão e o número de novos cas
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os notificados, proteger as populações mais vulneráveis e dar tempo aos países para aumentarem os serviços críticos de saúde e diagnóstico. Embora estas acções rápidas tenham ganho tempo para os Estados-Membros, os impactos socioeconómicos negativos estão a fazer-se sentir amplamente e os países estão agora a estudar a melhor forma de atenuar estas medidas, ao mesmo tempo que gerem o surto.
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Временные рекомендации
17 января 2020 г.
Цель настоящего документа – предоставить временные рекомендации лабораториям и субъектам, занятым в работах по лаборатор
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ному тестированию пациентов в случаях, соответствующих определению подозрительных на пневмонию, ассоциированную с новым коронавирусом, выявленным в Ухане, Китай (см. Surveillance case definitions for human infection with novel coronavirus, Interim guidance (Эпиднадзор за случаями инфекции человека, вызванной новым коронавирусом, временные рекомендации (на английском языке)).
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Considérations pour l’assouplissement des mesures sociale et de sante publique (MSSP), y compris le verrouillage dans les États membres de l’Union Afrique
En réponse aux premiers cas de maladie à coronavirus 2019 (COVID-19) signalés sur le continent, de nombreux États membres de l'Union a
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fricaine ont rapidement mis en œuvre des mesures sanitaires et sociales (PHSM) à grande échelle. Ces mesures visaient à réduire la transmission et le nombre de nouveaux cas signalés, à protéger les populations les plus vulnérables et à laisser aux pays le temps de mettre en place des services de soins de santé et de diagnostic essentiels. Si ces actions rapides ont permis aux États membres de gagner du temps, les répercussions socio-économiques négatives se font largement sentir, et les pays étudient actuellement la meilleure façon d'assouplir ces mesures tout en continuant à gérer l'épidémie.
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Monkeypox is a rare viral zoonotic disease caused by a double stranded DNA virus that belongs to the Orthopoxvirus genus of the Poxviridae family.
