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Time has seen management for Cystic Fibrosis (CF) advance drastically, most recently in the development of the disease-modifying triple combination therapy ivacaftor/tezacaftor/elexacaftor. There is currently limited evidence regarding both the global epidemiology of CF and access to this transforma
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tive therapy - and therefore where needs are not being met. Therefore, this study aims to define gaps in access to CF treatment. The results show that a significant CF patient burden exists in countries where disease-modifying drugs are unavailable, and final figures are likely underestimates. This analysis shows the potential to improve rates of diagnosis and treatment for CF, so a higher percentage of patients receive the most effective triple combination treatment.
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Pneumonia and diarrhoea account for 23% of under-five mortality and were responsible for an estimated 1.17 million deaths in children under five globally. Furthermore, pneumonia and diarrhoea were responsible for 18% of mortality in children 5–9 years of age, resulting in an estimated 86 000 preve
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ntable deaths globally in 2021. Existing World Health Organization (WHO) guidance on the clinical management of pneumonia and diarrhoea has mainly focused on children less than 5 years of age.
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Rwanda’s national health sector is focused on the equitable delivery of high-quality health services. The Government of Rwanda (GoR) recognizes that developing human resources in the health sector is a critical factor to the well-being of the population. Development of the health workforce has bee
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n guided by the Human Resources for Health (HRH) Programme (2012-2019) and its successor, the National Strategy for Health Professions Development (NSHPD) (2020-2030). Rwanda has made significant progress in enhancing its skilled health workforce, with notable improvements in the health professional-to-population ratio over the past decade, attaining 13.4 doctors, nurses, midwives, pharmacists, and dentists per 10 000 people in 2022. Despite such progress, health workforce levels remain below national and global recommendations.
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Front. Trop. Dis. , 09 May 2023 Sec. Neglected Tropical Diseases Volume 4 - 2023 | https://doi.org/10.3389/fitd.2023.1087003
The world is facing a sustainable development crisis. The 2024 Financing for Sustainable Development Report: Financing for Development at a Crossroads finds that financing challenges are at the heart of the crisis and imperil the SDGs and climate action. The window to rescue the SDGs and prevent a c
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limate catastrophe is still open but closing rapidly. Financing gaps for sustainable development are large and growing – the estimates by international organizations and others are coalescing around $4 trillion additional investment needed annually for developing countries. This represents a more than 50% increase over the pre-pandemic estimates. Meanwhile, the finance divide has not been bridged, with developing countries paying around twice as much on average in interest on their total sovereign debt stock as developed countries. Many countries lack access to affordable finance or are in debt distress. Weak enabling environments are preventing progress. Average global growth has declined, while policy and regulatory frameworks still do not set appropriate incentives. Public budgets and spending is not fully aligned with SDGs. Private investors are not incentivised to invest enough in SDGs and climate action. The world is at a crossroads. This is the last chance to correct course if we want to achieve the SDGs by the 2030 deadline. Only an urgent, large-scale and sustainable investment push can help us achieve our global goals. Next year’s Fourth International Conference on Financing for Development in 2025 will be a once in 80-year opportunity to support coherent transformation of financing.
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Clinical Pharmacology: Advances and Applications, 2025:17 29–47
National tuberculosis (TB) prevalence surveys provide a nationally representative measurement of the burden of TB disease in the population, at a given point in time. Repeat surveys allow assessment of trends and tracking of progress towards national and global targets for reductions in TB disease b
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urden. Survey data also provide important insights that can help national TB programmes to identify ways to improve TB diagnosis and treatment.
National TB prevalence surveys are relevant in countries that do not yet have national disease notification and vital registration systems that are of sufficiently high quality and coverage to allow reliable tracking of TB disease burden.
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This Toolkit for ensuring rights-based and ethical use of digital technologies in HIV and health programmes is derived from the comprehensive UNDP Guidance on the rights-based and ethical use of digital technologies in HIV and health programmes document. The foundational UNDP Guidance document outli
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nes key ethical, human rights and technical considerations for countries adopting digital technologies for health, detailing human rights risks, norms and standards, and provides a practical checklist for assessment.
The Toolkit serves as a quick reference guide for UNDP staff, governments, partners, technology developers, and civil society organizations, designed to provide practical guidance for implementing ethical digital health solutions by distilling and structuring the in-depth information from the broader UNDP Guidance into six easy-access modules. Each module addresses a specific key issue by outlining definitions, ethical principles, key considerations, and recommendations that align with the comprehensive framework established by the UNDP Guidance.
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This brief report summarizes recent information on HIV drug resistance (HIVDR) in the era of integrase-strand transfer inhibitors (INSTI) for HIV prevention and treatment.
The ILO has joined forces with Gallup to carry out a groundbreaking global survey covering 50 countries that sheds further light on the causes of the persistence of HIV-related stigma and discrimination in the world of work.
Operational Guidance. This operational guidance provides a structured approach to support countries in sustaining priority services for HIV, viral hepatitis and sexually transmitted infections in the context of reduced external funding. The guidance is intended for national governments, public healt
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h programmes, community-led organizations, civil society, technical partners and donors working to safeguard priority services, support phased adaptation, protect health outcomes and preserve hard-won gains.
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Technology and digital tools are transforming everyday life, opening new opportunities for women and girls—but they are also being weaponized to harass, threaten, and silence them online. Technology-facilitated violence against women and girls (TF VAWG) is now a defining challenge for gender equal
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ity, closely linked to violence offline and shaped by deep-rooted discrimination.
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Technical Brief
Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV K-19 Tuberculosis/HIV Coinfection
Updated: September 12, 2024 Key Considerations and Recommendations
Technical Document
The document explains how Unitaid contributes to strengthening global pandemic prevention, preparedness, and response, particularly in low- and middle-income countries. It highlights lessons from the COVID-19 pandemic, including inequalities in access to health tools, and emphasizes the need for bet
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ter coordination, stronger health systems, and increased investment in research and development. The text describes Unitaid’s role in improving access to diagnostics, treatments, and medical oxygen, supporting regional manufacturing, and working with global partners to ensure faster and more equitable responses to future health emergencies.
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The document is a report by an expert group that presents a framework for improving future pandemic preparedness and emergency response, particularly in the context of India but with relevance to global health systems. It analyzes lessons learned from COVID-19 and past epidemics, identifies key weak
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nesses in areas such as governance, surveillance, data management, research, and coordination, and proposes a comprehensive strategy to address them. The report emphasizes the importance of early detection, strong public health infrastructure, coordinated governance, scientific innovation, and international collaboration. A central idea is the ability to respond effectively within the first 100 days of an outbreak by having systems, resources, and policies already in place. Overall, it aims to strengthen resilience and ensure faster, more efficient responses to future health crises.
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The 2025 Impact Report summarises Malaria Consortium's year in numbers and includes a message from the Chief Executive.
A manual for physicians and other senior health workers. This fourth revision of the manual reflects recent clinical experience and research findings in diarrhoea case management. Compared to earlier versions, it includes revised guidelines on the management of children with acute diarrhoea using th
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e new reduced (low) osmolarity ORS formulation and using zinc supplements, which have been shown to reduce duration and severity of diarrhoeal episodes, and revised guidelines for the management of bloody diarrhoea. Guidelines in the manual are based on the revised WHO chart that are included at the end of this document.
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