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BioDrugs. 2023 Sep 20;37(6):737–756. doi: 10.1007/s40259-023-00623-4
There are many malaria vaccine candidates in development, with more than a dozen of these in clinical development. RTS,S/AS01 (also known as Mosquirix) is the most advanced malaria vaccine and was shown to have modest efficacy
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against clinical malaria in phase III trials in 5- to 17-month-old infants. Following pilot implementation trials, the World Health Organisation has recommended it for use in Africa in young children who are most at risk of infection with P. falciparum, the deadliest of the human malaria parasites.
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This malaria comic provides an engaging and educational overview of the disease, covering topics such as transmission, symptoms, prevention and treatment. It uses illustrations and storytelling to simplify complex scientific information and raise awareness, promoting malaria control efforts and maki
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ng the topic accessible to a broad audience, including students, health workers, and the general public.
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Malaria No More is a non-profit organisation dedicated to eradicating malaria, a preventable and treatable disease, in our lifetime. Through innovative partnerships, advocacy and data-driven solutions, Malaria No More works globally to ensure access to prevention tools, diagnostics and treatment, pa
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rticularly in vulnerable regions. Malaria No More focuses on high-impact campaigns, technological innovation and policy engagement, collaborating with governments, health organisations and private sector partners to accelerate progress towards malaria eradication and save lives.
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The Malaria Atlas Project (MAP) is a global research initiative that provides high-resolution, evidence-based spatial data on malaria transmission, risk and impact. MAP combines field data, satellite imagery, and advanced geostatistical modelling to deliver open-access maps, datasets, and analytical
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tools that support malaria control and elimination strategies worldwide. MAP empowers researchers, policymakers, and public health practitioners by providing them with accurate, up-to-date geographic insights to inform resource allocation and intervention planning.
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Noncommunicable diseases (NCDs) are chronic medical conditions that are not spread from person to person. Unlike infectious diseases, which are caused by bacteria, viruses, or other pathogens, NCDs are typically long-lasting and result from a combination of genetic, physiological, environmental, and
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behavioral factors. NCDs are the leading cause of death worldwide and responsible for over 70% of global deaths each year. Over 80% of these deaths occur in low- and middle-income countries (WHO). Noncommunicable diseases pose a serious threat to global health because they are widespread, costly, largely preventable, and responsible for the majority of deaths worldwide. Reducing their impact requires coordinated efforts in prevention, early detection, and healthcare system strengthening, particularly in lower-income countries. The Toolbox on Noncommunicable Diseases (NCDs) can play a vital role in strengthening Global Healthcare systems by providing centralized, reliable, and up-to-date health information and resources like clinical guidlelines, education material as well as tools for prevention and health promotion.
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The emergence of SARS-CoV-2 has significantly altered the epidemiology of other infectious diseases, making investigations into its co-infection with malaria particularly relevant in endemic regions. This review examines the epidemiological, incubation and clinical features of the two diseases, high
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lighting the diagnostic challenges and strategies for accurate detection. Emerging immunological and genetic evidence indicates that prior exposure to malaria may reduce the severity of outcomes of SARS-CoV-2 infection through mechanisms involving ACE2 downregulation, TLR signalling, T-cell activation and upregulation of coinhibitory receptors. Additionally, potential control measures are discussed, including vaccine development, the repurposing of antimalarial drugs, the exploration of natural products, innovations in bioinsecticides, and the strengthening of electronic disease surveillance. These insights provide valuable guidance for clinical management and public health policy, while emphasising the need for continued research into the complex interactions between SARS-CoV-2 and malaria.
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These guidelines have been developed in simple, user-friendly language and they explain the procedures for patients’ access to and the safe management of Schedule I and II drugs that are necessary for the treatment and relief of moderate to severe pain. They provide both procedures for acquisition
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and information on records or documents that are necessary to ensure that these medicines are made available and accessible to patients across the entire health care delivery system (i.e. from tertiary institutions to primary level) and ensuring prevention of illicit non-medical use.
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For education to be competency-based and effective, appropriate training methodologies have to be used to support the learner to have the appropriate knowledge and to translate this knowledge into skills and competencies. Such education and training should lead to a change in attitudes, beliefs a
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nd values, thus making the palliative care graduate able to do their job very effectively. To that end, APCA has developed this new resource, which is a guide to effective teaching methodologies in palliative care, targeting educators and trainers across Africa. This guide has been developed to enable educators and trainers to acquire knowledge and skills for using effective, practical, participatory and experiential teaching methods, and to use these in extending learning to all health care providers in Africa. The methods presented in this guide are based on existing practical and documented evidence of effective palliative care education.
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The African Palliative Care Association is pleased to publish the first edition of Palliative Care Standards for Africa. The development of these standards was achieved through wide consultation with service beneficiaries and providers, and they have been developed to suit different levels of
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service delivery, from primary to tertiary. These standards are underpinned by the World Health Organization’s definition of palliative care, and recognise that scaling up palliative care requires a public health approach with four pillars: policy, education, drug availability and implementation. In addition, the increasing need to establish specific indicators of quality and effectiveness for palliative care has been a big driving force behind these comprehensive standards. It is APCA’s wish that they will provide a framework for the development of evaluation
and performance indicators that can facilitate programme improvement and development. The standards are designed to allow the development or improvement of palliative care across the different services levels, within the organisational capacity of various service providers. They describe a relationship between primary, intermediary and tertiary level service providers, with expectations for all providers articulated through detailed criteria for each standard. It is therefore expected that these standards will influence the planning and delivery of palliative care services at all levels of health care service delivery.
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he United Nations Development Programme’s (UNDP) Gender Equality Strategy 2022-2025 has
been created during turbulent times. Multiple crises and risks are threatening the world and
we are witnessing an alarming backlash against women’s rights and gender equality. Since the
COVID-19 pandemic h
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it, women have been nearly twice as likely to lose their jobs compared to
men. Yet less than 20 percent of policy measures implemented by countries across the world have
addressed women’s economic insecurity. Gender inequality also takes a toll on men and other
affected groups. For men, rigid gender norms can fuel risky behaviours resulting in violence, poor
health, and lower life expectancy.
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Assisted partner services, which contact partners of people with HIV and invite them for testing, are highly effective in diagnosing people unaware of their HIV status and offer a promising model for reaching the partners of people who inject drugs, a study carried out in Kenya has found. The study
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findings are published in the May edition of Lancet Global Health.
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It provides basic information on HIV/AIDS, STIs and Gender-Based Violence (GBV) during outreach session. This helps to increase awareness and risk perception of HIV, STI and GBV, motivate to seek HIV, STI and GBV services while sensitizing and empowering female sex workers transgender sex workers to
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prevent GBV by making them aware of sexual and reproductive health rights and legal provisions.
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The document “Pandemic Planning Response Guide” provides guidance for organizations on how to prepare for, respond to, and recover from a pandemic. It explains what a pandemic is and emphasizes the importance of advance planning to reduce disruptions to operations. The guide presents a structure
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d response framework based on different pandemic phases—from early alert and pre-pandemic preparation to the active pandemic phase and the recovery period afterward. For each phase, it outlines triggers, strategic actions, and practical tasks organizations should implement, such as establishing communication plans, ensuring business continuity, supporting remote work, managing supply chains, and protecting employee health and safety. In addition, the guide discusses key planning considerations like crisis communication, mental health impacts, transportation disruptions, and workforce management. Overall, the document serves as a practical template to help organizations maintain essential services and adapt their operations during a global health emergency.
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The NIAID Pandemic Preparedness Plan describes the strategy of the National Institute of Allergy and Infectious Diseases (NIAID) to strengthen research and development for future pandemic threats. The plan focuses on identifying and studying viruses with the potential to cause epidemics or pandemics
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and developing medical countermeasures such as vaccines, therapeutics and diagnostics. A key concept is the research on “prototype pathogens,” which represent virus families that may cause future outbreaks, allowing scientists to prepare tools and knowledge in advance. The document also outlines the importance of surveillance, epidemiological research, technological innovation, clinical trials and international collaboration to enable a faster and more effective response to emerging infectious diseases. Overall, the plan aims to improve scientific preparedness so that new health threats can be detected earlier and controlled more rapidly.
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The International Federation of Red Cross and Red Crescent Societies (IFRC) is the world’s largest volunteer-based humanitarian network. With our 190 member National Red Cross and Red Crescent Societies worldwide, we are in every community reaching 160.7 million people annually through long-term s
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ervices and development programmes, as well as 110 million people through disaster response and early recovery programmes. We act before, during and after disasters and health emergencies to meet the needs and improve the lives of vulnerable people. We do so with impartiality as to nationality, race, gender, religious beliefs, class and political opinions.
more
This report presents the results of a study on the impact of the full-scale war in Ukraine on women living with HIV. The report describes how the war has affected the employment, economic, and property status of women living with HIV, how it has impacted their
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health, and the challenges women have faced in raising children, family planning, accessing HIV services, and seeking help
more
Incorporating epidemics risk in the INFORM Global Risk Index
Poljanšek K., Marin-Ferrer M., Vernaccini L., Messina L.
European Commission – Joint Research Centre (JRC)
(2018)
C2
The document focuses on integrating epidemic risk into the INFORM Global Risk Index, a tool used to assess and compare crisis and disaster risks across countries. It explains how epidemics can significantly impact vulnerability and hazard exposure, and therefore should be systematically included in
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risk assessments. The report outlines methods, indicators, and data sources for incorporating epidemic risk into the index, improving its ability to capture health-related threats. Overall, the document aims to enhance risk analysis and support better preparedness, planning, and decision-making by providing a more comprehensive understanding of global risks.
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The second ECDC/EFSA/EMA joint report on the integrated analysis of antimicrobial consumption (AMC) and antimicrobial resistance (AMR) in bacteria from humans and food-producing animals addressed data obtained by the Agencies’ EU-wide surveillance networks for 2013–2015. AMC in both sectors, exp
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ressed in mg/kg of estimated biomass, were compared at country and European level. Substantial variations between countries were observed in both sectors. Estimated data on AMC for pigs and poultry were used for the first time. Univariate and multivariate analyses were applied to study associations between AMC and AMR. In 2014, the average AMC was higher in animals (152 mg/kg) than in humans (124 mg/kg), but the opposite applied to the median AMC (67 and 118 mg/kg, respectively). In 18 of 28 countries, AMC was lower in animals than in humans. Univariate analysis showed statistically-significant (p < 0.05) associations between AMC and AMR for fluoroquinolones and Escherichia coli in both sectors, for 3rd- and 4th-generation cephalosporins and E. coli in humans, and tetracyclines and polymyxins and E. coli in animals. In humans, there was a statistically-significant association between AMC and AMR for carbapenems and polymyxins in Klebsiella pneumoniae. Consumption of macrolides in animals was significantly associated with macrolide resistance in Campylobacter coli in animals and humans. Multivariate analyses provided a unique approach to assess the contributions of AMC in humans and animals and AMR in bacteria from animals to AMR in bacteria from humans. Multivariate analyses demonstrated that 3rd- and 4th-generation cephalosporin and fluoroquinolone resistance in E. coli from humans was associated with corresponding AMC in humans, whereas resistance to fluoroquinolones in Salmonella spp. and Campylobacter spp. from humans was related to consumption of fluoroquinolones in animals. These results suggest that from a ‘One-health’ perspective, there is potential in both sectors to further develop prudent use of antimicrobials and thereby reduce AMR.
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One of the principles underpinning the delivery of all essential services and coordination of those services is the “survivor-centered approach”, which places the human rights, needs, and wishes of women and girl survivors at the centre of service delivery.
A key challenge faced by many entit
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ies working to end violence against women is ensuring that survivors’ voices and inputs are incorporated into policies, practices, and procedures on response. Survivors have diverse needs and face different risks. Not all women and girls experience violence in the same way. An effective intervention takes into account the realities of their unique circumstances, addresses individual needs, and reduces the risk for further harm and suffering.
UN Women, together with Global Rights for Women, have developed “Safe consultations with survivors of violence against women and girls”, which is designed to provide practical steps, safety measures, and actions that government agencies, civil society and survivor organizations, and United Nations’ entities can take to incorporate survivors' voices into systemic reform efforts, through safe and meaningful consultations.
This guidance is intended to help policymakers develop survivor-centered programming on ending violence against women and girls that meets the needs of diverse groups of women and girls, including those who are at higher risk of experiencing violence and discrimination. It is applicable to programming across the health, justice and policing, and social services sectors, as well as coordination of these sectors, and will help improve the standard and delivery of essential services for women and girls who have experienced violence.
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Background: Despite several cycles of Mass Drug Administration (MDA), however, the prevalence of Soil-transmitted helminthiasis (STH) remains high in Bangladesh. A clear understanding of local knowledge, attitudes, and practices (KAP) related to the acceptance and utilization of MDA is critical for
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effective implementation of this intervention.
Methods: This research, a cross-sectional descriptive study that utilized quantitative methods, was conducted between February and June 2017. A total of 380 questionnaire surveys were distributed to school-aged children (SAC), the parents of SAC, and school teachers.
Results: Out of 160 SACs, 81.9% knew of STH and 75.6% knew of MDA. SAC showed a high awareness of STH and recognized the importance of preventive measures and MDA. In terms of the parents of SAC and school teachers, close to half of the respondents were knowledgeable about STH and MDA. While nearly all of the participants held positive attitudes toward MDA, the respondents pointed out that school-based MDA presents severe limitations, as non-school-going children are neglected by this effort. A total of 68.3% of all school teachers and 56.8% of all parents of SAC found MDA efforts to be effective.
Conclusion: STH infections still remain a significant public health burden in Bangladesh. Reforming the MDA policy is necessary to achieve the target of STH elimination.
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