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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Cervical Cancer in Women with HIV in Latin America and the Caribbean: Update and Steps Towards Elimination

PAHO, ICW-LATINA PAHO (2020) C_WHO

This fact sheet is based on a systematic review of the literature on HPV and cervical cancer epidemiology, and a survey on policies and practices related to the prevention and control of cervical cancer among women living with HIV (WLHIV) to PAHO Member States. It details scorecards on the advances ... more

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UNAIDS Guidance Note on HIV and Sex Work

UNAIDS (2012) C2

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Community-based rehabilitation: CBR guidelines - Supplementary booklet

Kamala Achu, Kathy Al Jubah, Svein Brodtkorb, et al. WHO (2010) C_WHO

Available in: English, French, Chinese, Spanish, Russian, Arabic, Thai, Korean, Tajik, Vietnamese, Uzbek http://www.who.int/disabilities/cbr/guidelines/en/

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National Leprosy Elimination Programme Operational Guidelines

National Center for Tuberculosis and Leprosy Control, Cambodia Ministry of Health (2015) CC

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Occupational health and safety policy and guidelines for the health sector

Ministry of Health Ghana; Ghana Health Service Ghana (2010) C1

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Information note on HIV and COVID-19

World Health Organization WHO (2020) C_WHO

People living with HIV depend on life-saving antiretroviral therapy (ART) and access to ART must be maintained during periods of travel restrictions and lockdowns resulting from the COVID-19 pandemic. The Information note on HIV and COVID-19 addresses common concerns people living with HIV have rega... more

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Atlas of adolescents and HIV In Latin America and the Caribbean

Unicef (2015)

· Relevant interventions · HIV country profiles · Adolescents country profiles

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NATIONAL STANDARDS AND GUIDELINES FOR THE CONDUCT OF MEDICAL/HEALTH MISSIONS IN NIGERIA

Federal Ministry of Health, Nigeria (2016) C2

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The people living with HIV stigma index

N. Amanzholov; A. Yakovleva; D. Kamaldinov Central Asian Association of People Living with HIV (2019) C2

Analytical Report Almaty 2015 Accessed: 26.09.2019

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Kenya Asthma Management Guideline

Ministry of Health (2021) CC

Bonchial asthma is the most common chronic respiratory disease in the world. In Kenya, it has been estimated that about 7.5% of the Kenyan population, nearly 4 million people, are currently living with asthma. Many cases tend to be underdiagnosed and undertreated which leads to high levels of morbid... more

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MSF Essential Drugs - Practical Guidelines 2022
recommended

Médecins sans Frontières MSF Médecins sans Frontières (2022) C2

Practical guide intended for physicians, pharmacists, nurses and medical auxiliaries. This guide is not a dictionary of pharmacological agents. It is a practical manual intended for health professionals, physicians, pharmacists, nurses and health auxiliaries invoved in curative care and drug managem... more

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National Health Strategy and Guidelines for Bangladesh

Ministry of Health and Family Welfare, Government of the People's Republic of Bangladesh (2009) C1

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Condoms - The prevention of HIV, other sexually transmitted infections and unintended pregnancies

UNAIDS (Joint United Nations Programme on HIVAIDS) (2016) C2

UNAIDS 2016 / Meeting Report

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The missing link: Rethinking and reprioritizing HIV and gender-based violence in fragile settings

UNAIDS (2024) CC

This report explores the extent to which evidence, policy, normative guidance and commitments on HIV and gender-based violence, and their interlinkages, is being translated into action on the ground in fragile settings. These issues are explored through the lens of training of peace support operatio... more